In an article, author is Singh, S, once mentioned the application of 168828-90-8, Category: Isoxazoles, Name is (S)-5-(Aminomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one, molecular formula is C14H18FN3O3, molecular weight is 295.3094, MDL number is MFCD18379308, category is Isoxazoles. Now introduce a scientific discovery about this category.
Design and synthesis of isoxazole containing bioisosteres of epibatidine as potent nicotinic acetylcholine receptor agonists
An efficient synthesis of isoxazole containing isosteres of epibatidine is described. The synthesis proceeded from N-tert-butoxycarbonyl (Boc)-exo-2-(methoxycarbonyl)-7-azabicyclo[2.2.1]heptane (9). Compound 9 was reacted with the dilithium salt of an appropriately substituted oxime in tetrahydrofuran (THF), Cyclodehydration of the resultant beta-keto oxime and deprotection of the N-Boc group in 5 N aqueous HCl afforded the isoxazole containing isosteres of epibatidine (6-8), The binding affinities of these compounds were determined at the nicotinic acetylcholine receptor for the displacement of [H-3]cytisine. The unsubstituted isoxazole containing isostere (6) showed the lower binding potency compared to the 3′-methylisoxazole isostere (7), Substitution with a phenyl group at the 3′-position of the isoxazole significantly reduced the binding potency. The in vivo toxicological studies of these analogs were also performed, The LD50 of the analogs ranged in the order: Me>H>Ph.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem