Let¡¯s face it, organic chemistry can seem difficult to learn, Safety of Ethyltriphenylphosphonium bromide, Especially from a beginner¡¯s point of view. Like 1530-32-1, Name is Ethyltriphenylphosphonium bromide, molecular formula is Isoxazoles, belongs to Isoxazoles compound. In a document, author is das Neves, Amarith R., introducing its new discovery.
Effect of isoxazole derivatives of tetrahydrofuran neolignans on intracellular amastigotes of Leishmania (Leishmania) amazonensis: A structure-activity relationship comparative study with triazole-neolignan-based compounds
Isoxazole analogues derived from the neolignans veraguensin, grandisin, and machilin G were previously synthesized with different substitution patterns through the bioisosterism strategy. These compounds were tested on intracellular amastigotes of Leishmania (Leishmania) amazonensis; the derivatives proved to be active against intracellular amastigotes, with IC50 values ranging from 0.4 to 25 mu M. The most active analogues were 4 ‘, 14 ‘, 15 ‘, and 18 ‘, with IC50 values of 0.9, 0.4, 0.7, and 1.4 mu M, respectively, showing high selectivity indexes (SI = 277.0; 625.0; 178.5 and 357.1). Overall, the isoxazole analogues did not induce nitric oxide (NO) production by infected cells; there was no evidence that NO influences the antileishmanial mechanism of action, except for compound 4 ‘. Trimethoxy groups as substituents seemed to be critical for antileishmanial activity. The SAR study demonstrated that the isoxazole compounds were more active than 1,2,3-triazole compounds with the same substitution pattterns, demonstrating the importance of the bioisosterism strategy in drug design.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem