In an article, author is Sekirnik, Angelina R., once mentioned the application of 622-40-2, Safety of 2-Morpholinoethanol, Name is 2-Morpholinoethanol, molecular formula is C6H13NO2, molecular weight is 131.17, MDL number is MFCD00006180, category is Isoxazoles. Now introduce a scientific discovery about this category.
Isoxazole-Derived Amino Acids are Bromodomain-Binding Acetyl-Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3
A range of isoxazole-containing amino acids was synthesized that displaced acetyl-lysine-containing peptides from the BAZ2A, BRD4(1), and BRD9 bromodomains. Three of these amino acids were incorporated into a histone H4-mimicking peptide and their affinity for BRD4(1) was assessed. Affinities of the isoxazole-containing peptides are comparable to those of a hyperacetylated histone H4-mimicking cognate peptide, and demonstrated a dependence on the position at which the unnatural residue was incorporated. An isoxazole-based alkylating agent was developed to selectively alkylate cysteine residues in situ. Selective monoalkylation of a histone H4-mimicking peptide, containing a lysine to cysteine residue substitution (K12C), resulted in acetyl-lysine mimic incorporation, with high affinity for the BRD4 bromodomain. The same technology was used to alkylate a K18C mutant of histone H3.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem