Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 57294-38-9, Name is Boc-GABA-OH, molecular formula is C9H17NO4. In an article, author is Kumar, P. Ravi,once mentioned of 57294-38-9, Computed Properties of C9H17NO4.
Synthesis of Novel Diaziridinyl Quinone Isoxazole Hybrids and Evaluation of Their Anti-Cancer Activity as Potential Tubulin-Targeting Agents
Two series of diaziridinyl quinone isoxazole derivatives were prepared and evaluated for their cytotoxic activity against MCF7, HeLa, BT549, A549 and HEK293 cell lines and interaction with tubulin. Compounds (6a-m) showed promising activity against all the 5 human cancer cell lines. Compounds 6a, 6e and 6 m were potent [IC50 ranging between 2.21 mu g to 2.87 mu g] on ER-positive MCF7 cell line similar to the commercially available drug molecule Doxorubicin. The results from docking models are in consistent with the experimental values which demonstrated the favourable binding modes of compounds 6a-m to the interface of a-and ss-tubulin dimer.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem