33282-15-4, Name is 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid, belongs to Isoxazoles compound, is a common compound. COA of Formula: C10H7NO4In an article, once mentioned the new application about 33282-15-4.
Antimitotic Agents. Alterations at the 2,3-Positions of Ethyl (5-Amino-1,2-dihydropyrido<3,4-b>pyrazin-7-yl)carbamates
The reaction of ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (2) with alpha-amino ketone oximes gave 4-<(2-oxoethyl)amino>pyridine oximes 3, which were reductively cyclized to give a series of ethyl (1,2-dihydropyrido<3,4-b>pyrazin-7-yl)carbamates (6).In another approach, alpha-nitro ketones, alpha-oximino ketones, and alpha-nitro alcohols were reduced to give alpha-amino alcohols, which were reacted with 2 to give 4-<(2-hydroxyethyl)amino>pyridines (5).Oxidation of these alcohols with the chromium trioxide-pyridine reagent gave the corresponding ketones (4), which were also reductively cyclized to give 6.Structure-activity relationship studies indicated that alterations at the 2- and 3-positions of the pyrazine ring of 6 had a significant effect on cytotoxicity and the inhibition of mitosis in cultured lymphoid leukemia L1210 cells.Compounds that exhibited in vitro cytotoxicities at less than 1 nM showed the same level of in vivo activity, whereas the less potent compounds showed wide variations in their in vivo activity.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem