Electric Literature of 1072-67-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1072-67-9, Name is 5-Methylisoxazol-3-amine, molecular formula is C4H6N2O. In a Article£¬once mentioned of 1072-67-9
Structure-activity relationships of N2-aryl-3-(isoxazolylsulfamoyl)-2- thiophenecarboxamides as selective endothelin receptor-A antagonists
We report here that N2-aryl-3-(isoxazolylsulfamoyl)-2- thiophenecarboxamides are potent and selective small molecule ET(A) receptor antagonists. The aryl group was subjected to extensive structural modification. With monosubstitution, the para position was most useful in increasing potency, with methyl being preferred. With disubstitution, 2,4- disubstitution further enhanced activity with methyl or cyano groups being preferred at the 2-position. In this series, a benzo[d][1,3]dioxole group is equivalent to a 4-methyl group in in vitro activity and afforded the compounds with both in vivo activity and moderate half-lives.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem