In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of 3-Methylisoxazole-4-carboxylic acid, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 17153-20-7, name is 3-Methylisoxazole-4-carboxylic acid. In an article£¬Which mentioned a new discovery about 17153-20-7
A 3 – substituted – 4 – isoxazole carboxylic acid synthesizing method (by machine translation)
The invention relates to a high-purity, high regional selective 3 – substituted – 4 – isoxazole carboxylic acid synthesizing method. This approach is simple and easy to operate, mild reaction, high yield, to solve the existing preparation method of the harsh reaction conditions, with the isomer generating, separation difficulties; low overall yield, not easy mass production technical problems. The preparation steps: to 3 – substituted – 3 – oxo third ester (I) as the starting material, with the hydroxylamine hydrochloride and alkali in water in the cyclization reaction to obtain 3 – substituted – 4 – isoxazole – 5 – one (II); compound (II) and N, N – dimethyl formamide dimethyl acetal reaction produce 4 – dimethylamino methylene – 3 – substituted – 4 – hydrogen – isoxazole – 5 – one (III); compound (III) under alkaline condition, experience lactone hydrolysis open-loop, re-ring; acidifying the resulting 3 – substituted – 4 – isoxazole carboxylic acid. The invention is used for 3 – substituted – 4 – isoxazole carboxylic acid development and large-scale preparation. (by machine translation)
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 17153-20-7, help many people in the next few years.Safety of 3-Methylisoxazole-4-carboxylic acid
Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem