With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14678-02-5,5-Amino-3-methylisoxazole,as a common compound, the synthetic route is as follows.
Example 178; N-(4-Chloro-3-methylisoxazol-5-yl)-4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide; (1) 4-Chloro-3-methylisoxazole-5-amine; To a solution of 3-methylisoxazole-5-amine (5.00 g, 51.0 mmol) in dichloromethane (40 ml) was slowly added N-chlorosuccinimide (6.80 g, 51.0 mmol) with ice-cooling and the mixture was stirred for 1 hour with ice-cooling and then at room temperature for 2 hours. The reaction mixture was washed with an aqueous 1N sodium hydroxide solution and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. Hexane was added to the residue and the desired product (5.65 g, 83.6%) as a solid was collected by filtration. 1H-NMR (CDCl3) delta; 2.18 (3H, s), 4.54 (2H, br s).
14678-02-5 5-Amino-3-methylisoxazole 84590, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1813606; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem