Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: Isoxazoles. Introducing a new discovery about 206055-91-6, Name is (3-(4-Bromophenyl)isoxazol-5-yl)methanol
Synthesis of 1,1?-ferrocene diformates bearing isoxazole moiety and preliminarily cytotoxicity to A549, HCT116 and MCF-7 cell lines
Background: Ferrocene is a potential pharmacophore for drug design and drug discovery. Methods: Based on our previous good achievements (Med. Chem. commun., 2014,7,968-972), nineteen novel structures of 1,1?-ferrocene diformates bearing isoxazole moiety (3a-3s) were firstly synthesized in the current work and characterized by 1H NMR, 13C NMR, ESI-MS. Then, their cytotoxicity to A549, HCT116 and MCF-7 cell lines was evaluated using the MTT method. Results: The results showed that most compounds exhibited higher potent cytotoxicity to A549, HCT116 and MCF-7 cell lines. Conclusion: Especially, 3b, 3h, 3k, 3l, 3m, 3n, 3o, 3p and 3s simultaneously exhibited stronger inhibitory activity towards A549, HCT116 and MCF-7 cell lines than that of the reference drug cisplatin, which can be regarded as very promising metal-based lead compounds for anticancer agents.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: Isoxazoles, you can also check out more blogs about206055-91-6
Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem