1750-42-1, Isoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 64 Preparation of 2-{3-[2-(4-chlorophenyl)ethyl]-5-oxo-1-phenyl-2-sulfanylideneimidazolidin-4-yl}-N-(1,2-oxazol-3-yl)acetamide. Oxalyl chloride (44.8 muL; 0.51 mmol; 2 eq) and dimethylformamide (0.3 mL) were added to a solution of 2-{3-[2-(4-chlorophenyl)ethyl]-5-oxo-1-phenyl-2-sulfanylideneimidazolidin-4-yl}acetic acid (1-3) (100 mg; 0.26 mmol; 1 eq) in dichloromethane (6 mL). The reaction mixture was stirred at room temperature for 3 hours. Then, pyridine (62 muL; 0.77 mmol; 3 eq) and 1,2-oxazol-3-amine (38 muL; 0.51 mmol; 2 eq) were added. The mixture was stirred at room temperature over the week-end. Saturated ammonium chloride (30 mL) was added and the aqueous layer was extracted with ethyl acetate (3 x 30 mL). The combined organic layers were washed with saturated sodium chloride (3 x 30 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude was purified on silica gel using dichloromethane/ethyl acetate (95/5 to 50/50) as an eluent. After trituration in diethyl ether and lyophilisation, the title compound 2- {3-[2-(4-chlorophenyl)ethyl]-5-oxo-1-phenyl-2-sulfanylideneimidazolidin-4-yl}-N-(1,2-oxazol-3-yl)acetamide was obtained in 25% yield (29.25 mg) as a white powder. 1H-NMR (DMSO-d6): delta (ppm) 2.89 (m, 1H), 3.03 (m, 1H), 3.18 (m, 1H), 3.39 (m, 1H), 3.71 (m, 1H), 4.17 (m, 1H), 4.8 (t, 1H), 6.9 (d, 1H), 7.32 (m, 4H), 7.38 (m, 2H), 7.48 (m, 3H), 8.81 (d, 1H), 11.34 (s, 1H); MS (ESI+): m/z = 454.8, 456.8 [M+H]+.
As the paragraph descriping shows that 1750-42-1 is playing an increasingly important role.
Reference£º
Patent; Vivalis; Guedat, Philippe; Berecibar, Amaya; Ciapetti, Paola; Venkata Pithani ,Subhash; Trouche, Nathalie; EP2664616; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem