With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.110256-15-0,5-Cyclopropylisoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.
A mixture of 23.0 mg (0.15 mmol) of 5-cyclopropyl-isoxazole-3-carboxylic acid, 30 mu (0.21 mmol) of triethylamine, 63.2 mg (0.18 mmol) of 1-amino- cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-l -yl]- benzylamide (Reference Example 4) 60.0 mg (0.16 mmol) of HATU and 1 mL of N,N- dimethylformamide was stirred at room temperature for 24 h. The reaction mixture was purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and hexane:ethyl acetate = 4: 1 as eluent to yield 26 mg (31 %) of the title compound. MS (EI) 557.2 (MH+).
As the paragraph descriping shows that 110256-15-0 is playing an increasingly important role.
Reference£º
Patent; RICHTER GEDEON NYRT.; BEKE, Gyula; BENYEI, Gyula Attila; BORZA, Istvan; BOZO, Eva; FARKAS, Sandor; HORNOK, Katalin; PAPP, Andrea; VAGO, Istvan; VASTAG, Monika; WO2012/59776; (2012); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem