78967-07-4, Mofezolac is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation of 3,4-bis(4-methoxyphenyl)-5-hydroxyethylisoxazole (X) To a solution of mofezolac (VII) (200 mg, 0.589 mmol), in anhydrous THF (2 mL) kept at 0 C by a bath of ice, 1M BMS in THF (1.16 mL, 1.16 mmol) was added dropwise, and the mixture was stirred overnight at room temperature to give a pale yellow homogeneous solution. Distilled water (1 mL), 20% NaOH (I mL) and 35% H202 (1 mL) were added and the obtained reaction mixture was stirred for 1 hour. Then, the solution was extracted with ethyl acetate. The organic layer was dried over anhydrous Na2S04 and the solvent removed under reduced pressure. The product (X) was isolated as a white solid (68% yield) by flash chromatography on silica gel (hexane/ethyl acetate 6:4) of the reaction crude, the NMR (400 MHZ, CDC13, delta): 3.81 (s, 3H, CH3), 3.85 (s, 3H, CH3); 4.44 (t, 2H, J- 6.6 Hz CH2), 4.26 (t, 2H, J= 6.6 Hz CH2 6.85 (d, 2H, J= 9.0 Hz, ArH), 6.95 (d, 2H, J= 9.0 Hz, ArH), 7.21 (d, 2H, J= 9.0 Hz, ArH); 7.39 (d, 2H, J= 9.0 Hz, ArH). ESI-MS: m/z (%): C18H20NO4 (M)+, 325.
The synthetic route of 78967-07-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UNIVERSITA’ DEGLI STUDI DI BARI; SCILIMATI, Antonio; PERRONE, Maria, Grazia; VITALE, Paola; WO2014/115020; (2014); A1;,
Isoxazole – Wikipedia
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