With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108655-63-6,3-(Trifluoromethyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.
Example 1 3-Trifluoromethyl-5-hydroxyisoxazole A solution of 36 % HCl (9.12 g, 15 eq.) and n-propanol (9.0 ml) was added to 5-amino-3-trifluoromethyl-isoxazole (0.91 g, 6.0 mmole) from Preparation 1 and heated at reflux for 23 hours. The reaction mixture was cooled, extracted with methylene chloride and distilled under reduced pressure to give 0.006 g (0.7 %) of the titled compound as a cololess liquid, b.p. 35 – 37C/1.4 mmHg.
108655-63-6 3-(Trifluoromethyl)isoxazol-5-amine 13913996, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; SHIONOGI & CO., LTD.; EP220025; (1991); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem