1008-75-9, Name is 3-Methyl-5-phenylisoxazole, belongs to Isoxazoles compound, is a common compound. Recommanded Product: 3-Methyl-5-phenylisoxazoleIn an article, once mentioned the new application about 1008-75-9.
Synthesis of optically active beta’-hydroxy-beta-enaminoketones via enzymatic resolution of carbinols derived from 3,5-disubstituted isoxazoles
The preparation of several enantiomerically pure beta’-hydroxy-beta-enaminoketones from the corresponding isoxazolic carbinols, which have been obtained by enzymatic kinetic resolution of the racemic beta-hydroxyisoxazoles catalyzed by lipases, is described. The enzymatic transesterification of racemic (¡À)-5-(2-hydroxypropyl)-3-methylisoxazole 3a, and racemic (¡À)-5-(2-hydroxy-2-p-tolylethyl)-3-methylisoxazole 3d, has been studied with respect to the influence of experimental variables such as the used enzyme, the acylating agent or the solvent on the enantioselectivity of the reaction. After the reductive cleavage of the isoxazolic ring of the enantiopure carbinols, (R)- and (S)-2-amino-4-oxo-2-hepten-6-ol, (R)- and (S)-5, and (R)-2-amino-6-p-tolyl-4-oxo-2-hexen-6-ol, (R)-7 with an enantiomeric excess >98% were obtained. Copyright (C) 2000 Elsevier Science Ltd.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem