108511-97-3, Isoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 4 (11.51 g, 0.022 mol),Isoxazol-4-ylamine (11.85g, 0.022mol) and p-toluenesulfonic acid(~0.40g) of the suspension was placed in a mechanical stirrer,In a round bottom flask with an oil bath and a Dean-Stark condenser,The reaction mixture is heated to reflux (internal temperature 150-155 C,Oil bath temperature 170-180 C) 15-18 hours,The reaction was monitored by TLC at the same time. After completion of the reaction, the reaction mixture was cooled to 80 C, and methanol (27 mL) was slowly added through a dropping funnel.The reaction mixture was slowly cooled to room temperature with stirring.The resulting solid was filtered and washed with methanol (45 mL).And dried at 100-120 C for 2 hours.Obtained as a white solid ((3-((4,6-difluorobenzo[d]thiazol-2-yl)methyl)thio)-1-(isoxazol-4-ylamino)-1-oxyl Propane-2-carboxylic acid (9H-fluoren-9-yl)yl carbamate (Compound 5), 9.26 g,The yield was 71%.
The synthetic route of 108511-97-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Qin Jiwei; (13 pag.)CN108892664; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem