Application of 33282-15-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.33282-15-4, Name is 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid, molecular formula is C10H7NO4. In a Article£¬once mentioned of 33282-15-4
New asymmetric synthesis of (-)-esermethole
A new synthesis of (-)-esermethole, based on the asymmetric alkylation at C(3) of racemic 1,3-dimethyl-5-methoxyoxindole (3), is described. The chloroacetyl derivatives of (-)-menthol and (S)-N-methyl-(1-phenylethyl) amine were chosen as chiral alkylating agents and used under different reaction conditions (temperature, solvent and base). In particular, the latter reacted with 3 in toluene at 10C, in the presence of t-butyllitium, giving (3S,1’S)-N-methyl-N-(1′-phenylethyl)-1,3-dimethyl-5-methoxyoxindol-3-i lacetamide (10) with a 63% d.e.. This intermediate was easily separated from the undesired minor (3R,1’S) diastereomer (11) and converted to (-)-esermethole (99.6% e.e.) in two steps.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 33282-15-4
Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem