Awesome and Easy Science Experiments about 300-87-8

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300-87-8, Name is 3,5-Dimethylisoxazole, belongs to Isoxazoles compound, is a common compound. Application In Synthesis of 3,5-DimethylisoxazoleIn an article, once mentioned the new application about 300-87-8.

Reduction of Heterocycles with Nickel-Aluminum Alloy

Pyrazines, pyridazines, isoxazoles, oxazole, 4-methylpyrimidine, and indole are reduced by nickel-aluminum alloy in potassium hydroxide solution.The reaction is simple to carry out and does not require special apparatus or hydrogen atmospheres.The products were the fully hydrogenated species although benzene rings were not attacked. 4-Methylpyrimidine gave 1,3-diaminobutane and oxazole gave 2-(methylamino)ethanol.It was found that the reaction frequently exhibited an induction period.

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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem