Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: Isoxazoles. Introducing a new discovery about 90924-12-2, Name is (3-Phenyl-5-isoxazolyl)methanol
A rapid and efficient solvent-free microwave-assisted synthesis of pyrazolone derivatives containing substituted isoxazole ring
An efficient synthesis of 4-substituted pyrazolone derivatives was developed. 4-Substituted pyrazolone derivatives were synthesized in 78-97% yields starting from various 3-substituted isoxazole-5-carbaldehydes, ethyl acetoacetate and hydrazine under microwave irradiation and solvent-free conditions, and were characterized by HRMS, FTIR, 1H NMR and 13C NMR spectroscopy. SiO2 was found to possess favorable catalytic activity and dispersancy for the condensation reaction. The merits of this method include the environmentally friendly reaction conditions, simple operation, broad substrate, satisfied yields and the reuse of the silica. Moreover, the crystal structure of the compound 2-(4-chlorophenyl)-4-((1-(4-chlorophenyl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)(3-phenylisoxazol-5-yl)methyl)-5-methyl-1H-pyrazol-3(2H)-one (5a) in the monoclinic space group C2/c was presented.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: Isoxazoles, you can also check out more blogs about90924-12-2
Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem