Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. SDS of cas: 300-87-8. Introducing a new discovery about 300-87-8, Name is 3,5-Dimethylisoxazole
Palladium-catalysed direct heteroarylation of bromobenzylacetamide derivatives: A simple access to heteroarylated benzylamine derivatives
The palladium-catalysed direct arylation of bromobenzylacetamide derivatives using a wide variety of heteroaromatics gives a very simple access to heteroarylated benzylacetamides. 2-, 3- and 4-Bromobenzylacetamides present a very similar reactivity. In the presence of 2-subtituted furans, thiophenes, pyrroles, thiazoles, or imidazoles a regioselective 5-arylation was observed. The reaction of benzoxazole gave the 2-arylated compounds; whereas 3,5-dimethylisoxazole gave the 4-arylated products. In most cases, the system using PdCl(C(dppb) as the catalyst, KOAc as the base, and DMAC as the solvent gave high yields of coupling products. Georg Thieme Verlag Stuttgart New York.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 300-87-8, you can also check out more blogs about300-87-8
Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem