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Benzazepine derivatives, their preparation and use (by machine translation)
The invention belongs to the technical field of medicines, and in particular discloses a benzodiazepine compound which has a structure shown as a formula I as well as pharmaceutically acceptable salt, wherein n is 1, 2, 3 or 4; X and Y are respectively C, N or N, C; R1 is hydrogen, methyl, ethyl, trifluoromethyl and chlorine; R2 is =O or -OH; R3 and R4 are simultaneously or respectively hydrogen, halogen, C1-4 alkyl, C1-4 alkyl substituted by halogen, C1-4 alkoxyl, C1-4 carbalkoxyl, phenyl, halogenated phenyl, alkoxyl phenyl and cyano. The invention further discloses a preparation method of the compound and a pharmaceutical composition which takes the compound or the pharmaceutically acceptable salt as an active effective component as well as an application thereof in preparing antitumor medicines, particularly medicines for treating breast cancer, lung cancer and gastric cancer.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem