Day: November 6, 2020

31329-64-3, 3,5-Dimethylisoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 1 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (3,5-dimethylisoxazole-4-yl)-amide Oxalyl chloride (0.2 ml) was added to a suspension of 4-difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid (0.3 g) in dichloromethane (20 ml) at room temperature under an atmosphere of nitrogen. Three drops of N,N-dimethylformamide were added, and the mixture stirred for 18 hours. The solvent was removed in vacuo and the residue dissolved in dichloromethane (20 ml). The resulting solution was added to a mixture of 3,5-dimethylisoxazol-4-ylamine (0.16 g) and triethylamine (0.2 ml) in dichloromethane (20 ml) at room temperature under an atmosphere of nitrogen. The mixture was stirred for 2 hours, then washed with aqueous sodium bicarbonate (2*20 ml) and water (20 ml). The organics were dried over magnesium sulphate, filtered and the solvent removed in vacuo. Purification by column chromatography on silica eluding with 50% ethyl acetate in heptane afforded the title compound as a white solid (0.29 g). TLC Rf 0.65 (ethyl acetate). Mass spectrum m/z 350 (M-1), 31329-64-3

As the paragraph descriping shows that 31329-64-3 is playing an increasingly important role.

Reference£º
Patent; Darwin Discovery, Ltd.; US6403791; (2002); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33282-23-4,5-(4-Bromophenyl)isoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: A solution of isoxazole acid derivative 1 (1mmol), EDCI (1.1mmol), and HOBt (1mmol) in dry acetonitrile (10mL) was stirred at room temperature for 30min. Then, 3-picolylamine 2a or 4-picolylamine 2b (1mmol) was added drop wise to the mixture and the reaction was continued at room temperature for 24h. After completion of the reaction, the solvent was reduced under vacuum and the residue was dissolved in dichloromethane and washed with sodium carbonate (10%, 3¡Á20). The organic phase was dried over Na2SO4 and the solvent was evaporated under vacuum to give compound 3 which was completely pure. Finally, the mixture of compound 3 (1mmol) and benzyl halide derivative 4 (1.2mmol) in dry acetonitrile (10mL) was heated at reflux for 10-15h. After completion of the reaction which was monitored by TLC, the mixture was allowed to be cool and the precipitates were filtered off to afford products 5a-q in good yields., 33282-23-4

The synthetic route of 33282-23-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vafadarnejad, Fahimeh; Karimpour-Razkenari, Elahe; Sameem, Bilqees; Saeedi, Mina; Firuzi, Omidreza; Edraki, Najmeh; Mahdavi, Mohammad; Akbarzadeh, Tahmineh; Bioorganic Chemistry; vol. 92; (2019);,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

33282-15-4, 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of oximic acid (4a-k, 3.6 mmol in 50 mL THF) was added HOBt (3.6 mmol) in an ice-cooled bath. Next, a mixture of cystamine dihydrochloride (1.8 mmol) and TEA (1 mL) in DMSO (6 mL) were added, followed by the addition of EDCI (4.0 mmol). After stirring for 24 h at room temperature, the reaction was quenched with water and extracted with EtOAc (60 mL ¡Á 3). The combined organic extracts were washed with brine (50 mL), dried over MgSO4 and then evaporated. The resulting residue was then purified by column chromatography on silica gel as indicated., 33282-15-4

The synthetic route of 33282-15-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wen, Jiachen; Bao, Yu; Niu, Qun; Liu, Jiang; Yang, Jinyu; Wang, Wanqiao; Jiang, Tao; Fan, Yinbo; Li, Kun; Wang, Jian; Zhao, Linxiang; Liu, Dan; Bioorganic and Medicinal Chemistry Letters; vol. 26; 17; (2016); p. 4372 – 4376;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

3356-89-6, 5-Chloro-3-phenylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 5-chloro-3-phenylisoxazole (2) (5 mmol), thiol (10 mmol) and K2CO3 (15 mmol) in DMF (25 mL) was stirred for 36 h at r.t. The reaction mixture was diluted with H2O (40 mL) and extracted with CH2Cl2 (3 ¡Á 20 mL). The combined organic layers were dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel using hexane-EtOAc as the eluent to give the desired compound. 3-Phenyl-5-[(2,2,2-trifluoroethyl)sulfanyl]isoxazole (6a) Yield: 1.28 g (99%); colorless oil. 1H NMR (400 MHz, CDCl3): delta = 7.85-7.75 (m, 2 H), 7.54-7.44 (m, 3 H), 6.69 (s, 1 H), 3.66 (q, J = 9.3 Hz, 2 H). 13 NMR (100 MHz, CDCl3): delta = 163.5, 162.3, 130.4, 129.0, 128.3, 126.8, 124.5 (q, J = 277 Hz), 105.0, 35.3 (q, J = 34.4 Hz). HRMS (ESI): m/z [M + H]+ calcd for C11H9F3NOS: 260.0351; found: 260.0355., 3356-89-6

The synthetic route of 3356-89-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Rostovskii, Nikolai V.; Agafonova, Anastasiya V.; Smetanin, Ilia A.; Novikov, Mikhail S.; Khlebnikov, Alexander F.; Ruvinskaya, Julia O.; Starova, Galina L.; Synthesis; vol. 49; 19; (2017); p. 4478 – 4488;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3405-77-4,5-Methylisoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 1. Compound of formula B, wherein R = (compound 31).To a solution of compound A (25.0 mg, 0.039 mmol), S-methylisoxazole-S-carboxylic acid (5.4 mg, 0.043 mmol) and HATU (16.2 mg, 0.043 mmol) in DMF (0.5 mL) was added diisopropylethylamine (15.0 mg, 0.116 mmol). The reaction mixture was stirred at 25 0C for 16 h and then evaporated under a positive flow of nitrogen. The residue was purified by reverse phase chromatography to give the desired product (20.8 mg, 71percent yield). MS (ESI): m/z = 755.1 [M+H]., 3405-77-4

3405-77-4 5-Methylisoxazole-3-carboxylic acid 76947, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; WO2009/73713; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7063-99-2,Ethyl 5-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

7063-99-2, General procedure: Sodium hydroxide (2N) was added to a solution of intermediate 2a-i (1 equiv.) in methanol at ambient temperature. The reaction mixture was stirred for 4h and the methanol was removed by rotary evaporation. The resultant mixture was adjusted to pH=5-6 with 1N HCl solution. The precipitated white solid was collected by filtration and dried to give the carboxylic acid intermediate (1a-i). 4.13.1 5-Phenylisoxazole-3-carboxylic acid(1a) (0032) Light white solid; yield: 91.5%; 1H NMR (600MHz, DMSO-d6) delta 7.95 (dd, J=7.8, 1.7Hz, 2H), 7.58-7.53 (m, 3H), 7.41 (s, 1H).

As the paragraph descriping shows that 7063-99-2 is playing an increasingly important role.

Reference£º
Article; Zhao, Shizhen; Zhang, Xiangqian; Wei, Peng; Su, Xin; Zhao, Liyu; Wu, Mengya; Hao, Chenzhou; Liu, Chunchi; Zhao, Dongmei; Cheng, Maosheng; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 96 – 107;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1136-45-4,5-Methyl-3-phenylisoxazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Dissolve the free piperazino-piperidine of Example 11, step 6 (1.7 g, 3.3 mmol) in CHCl3 (30 ml;=Stock solution A). Add 250 ul of stock solution A (0.027 mmol) to a slurry of 0.15 g (0.14 mmol ) of resin bound cardodiimide (prepared by reacting Argopore-Cl resin with 1-(3-dimethyl-aminopropyl)3-ethyl carbodiimide in DMF at 100 C. in DMF (1.5 ml) in a polyethylene SPE cartridge. To this mixture add 75 ul of a 1 M solution of 5-methyl-3-phenylisoxazole-4-carboxylic acid in DMF (0.075 mmol), and HOBT (24 ul of a 1M solution in DMF). Shake this mixture for 14 h, filter and add 0.1 g of Amberlyst-15 resin (0.47 mmol) to the filtrate. Shake for 1 to 2 h, filter and wash the resin twice with each of the following solvents THF, CH2Cl2 and CH3OH, then wash with THF and CH2Cl2. Treat the resin with 2M NH3 in CH3OH (1 time for 30 min, and 1 time for 5 min). Combine and concentrate the filtrates under reduced pressure to afford the title compound. LCMS found MH+=599.1 (calculated MW 598); TLC Rf=0.74 (CH2Cl2/CH3OH/NH4OH (95/5/0.5)).

1136-45-4, The synthetic route of 1136-45-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schering Corporation; US6391865; (2002); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51677-09-9,Methyl 5-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

51677-09-9, To a solution of 1-2 (1.0 g, 4.9 mmol) in MeOH (10 mL) was added sodium hydroxide solution (20 mL, 4 M). The reaction mixture was stirred at room temperature for 2 hours and concentrated under reduced pressure to remove MeOH. The aqueous phase was acidified with aqueous HCl (1 M) till pH=3 and the mixture was extracted with EtOAc, dried with anhydrous Na2SO4, filtered and concentrated to give the crude product. The crude product was purified by silica gel chromatography eluted to give product 1-2 (0.7 g, 79.5%). MS m/z [ESI]: 190.0 [M+1].

The synthetic route of 51677-09-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUZHOU SINOVENT PHARMACEUTICALS CO., LTD.; WANG, Yonghui; ZHU, Yan; ZHOU, Juan; GAO, Yujun; WANG, Shiqun; WANG, Dong; LIU, Wandeng; SHEN, Ximing; HONG, Binbin; LIU, Tao; WU, Yaodong; LI, Chunqi; (35 pag.)US2018/271846; (2018); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (0.270 g) was dissolved in absolute ethanol (4.5 ml). Methylamine (2M in THF, 3.16 ml) was added. The vial was sealed and stirred at 70C overnight. The reaction mixture was cooled to room temperature and the solvent was evaporated in vacuo. The crude product was purified via flash column chromatography (1-4% methanol in dichloromethane) affording the product as a white solid, 123770-62-7

123770-62-7 Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 8027233, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Dr. August Wolff GmbH & Co. KG Arzneimittel; Soeberdt, Michael; Knie, Ulrich; Abels, Christoph; EP2666766; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

78967-07-4, Mofezolac is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

78967-07-4, General procedure: N-Diisopropyl-N-ethylamine (DIEA, 0.215 mL, 1.237 mmol) andmethyl 5-aminopentanoate hydrochloride (6) (100 mg, 0.60 mmol)were solubilized in anhydrous CH2Cl2 (5 mL) and stirred at 0 C for1 h. Then, this solution was dropwise added to a stirred solution ofN,N’-dicyclohexylcarbodiimide (DCC, 170 mg, 0.825 mmol), 1-hydroxybenzotriazole monohydrate (HOBt H2O, 180 mg,1.05 mmol) and 2-[3,4-bis(4-methoxyphenyl)isoxazol-5-yl]aceticacid (mofezolac) (200 mg, 0.59 mmol) in anhydrous CH2Cl2 (20 mL)kept at 0 C. The reaction mixture was stirred for 19h at roomtemperature. Then, H2O was added and the aqueous solutionextracted with CH2Cl2. The combined organic layers were washedwith a sat. aqueous solution of K2CO3, dried over anhydrousNa2SO4, and the solvent was removed under reduced pressure.Column chromatography of the crude residue (silica gel; EtOAc/Hexane 3:7) allowed to isolated 8 (107 mg, 40% yield).

The synthetic route of 78967-07-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Perrone, Maria Grazia; Vitale, Paola; Ferorelli, Savina; Boccarelli, Angelina; Coluccia, Mauro; Pannunzio, Alessandra; Campanella, Federica; Di Mauro, Giuseppe; Bonaccorso, Carmela; Fortuna, Cosimo G.; Scilimati, Antonio; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 404 – 416;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem