Day: November 24, 2020

19788-37-5, 4-(Chloromethyl)-3,5-dimethylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 10 ml of dimethylformamide were added 1.1 g of 3-[bis(4-fluorophenyl)methyl]-4-piperidinone hydrochloride, 0.5 g of 4-chloromethyl-3, 5-dimethylisooxazole and 1.4 g of potassium carbonate and the mixture was stirred at room temperature for 16 hours.. The mixture was extracted with 30 ml of ethyl acetate, the extract was washed with water, and dried over magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain the title compound as an oil.1H-NMR (CDCl3) delta: 2.22, 2.32 (each s, 6H), 2.30-2.70 (m, 6H), 2.80 (m, 1H), 3.19 (s, 2H), 4.50 (d, 1H, J=11 Hz), 6.89-7.26 (m, 8H)., 19788-37-5

19788-37-5 4-(Chloromethyl)-3,5-dimethylisoxazole 88246, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; EP1460062; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1018297-63-6, (3-(4-Fluorophenyl)-5-methylisoxazol-4-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a) 3-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-isoxazole-5-carboxylic acid methyl ester To a solution of [3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol (1.0 g, 4.8 mmol) in THF (70 mL) was added 3-oxo-2,3-dihydro-isoxazole-5-carboxylic acid methyl ester (0.69 g, 4.8 mmol) and triphenylphosphine (1.65 g, 6.3 mmol) at ambient temperature under an argon atmosphere. Then diethyl azodicarboxylate (2.7 mL, 6.3 mmol) was added at 4 C. and the reaction mixture was stirred for 3 h at room temperature. Concentration and purification by chromatography (SiO2, heptane:ethyl acetate=100:0 to 7:3) afforded the title compound (958 mg, 60%) as a white solid. MS: m/e=333.2 [M+H]+.

1018297-63-6, As the paragraph descriping shows that 1018297-63-6 is playing an increasingly important role.

Reference£º
Patent; Hernandez, Maria-Clemencia; Jakob-Roetne, Roland; Lucas, Matthew C.; Thomas, Andrew; US2010/210651; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.

General procedure: A solution of Aryl-or heteroary-amine (1.0 mol) in chloroformor dichloromethane was stirred with potassium carbonate(1.5 mol). To this solution was then added 1.5 mol of chloroacetylchloride under cold. Reaction was stirred overnight at room temperature.After completion of reaction (monitored by TLC), solventwas removed under reduced pressure. To the solid mass, ice coldwater was added. The solid thus obtained was then filtered driedand recrystallized from ethanol., 1072-67-9

1072-67-9 5-Methylisoxazol-3-amine 66172, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Bhanushali, Umesh; Rajendran, Saranya; Sarma, Keerthana; Kulkarni, Pushkar; Chatti, Kiranam; Chatterjee, Suvro; Ramaa; Bioorganic Chemistry; vol. 67; (2016); p. 139 – 147;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

3209-71-0, Isoxazole-3-carboxylic Acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of isoxazole-3-carboxylic acid (28 mg, 0.223 mmol), HATU (84 mg, 0.223 mmol), triethylamine (95 ul, 0.67 mmol) and catalytic amount of DMAP in THF (2 mL) was stirred at room temperature for 5 minutes. 4-(benzo[d]oxazol-2-yl)-3-methylaniline (50 mg, 0.223 mmol) was added and the resulting mixture was stirred at 65 C for 18 h. The reaction mixture was diluted with DCM, washed with saturated solution of NaHCO3 and brine. The organic solution was, dried over Na2SO4, decanted and evaporated under reduced pressure. The crude was purified by column chromatography on silica gel using 1:4 to 1:2 EtOAc:Hexane as mobile phase to give N-(4- (benzo[d]oxazol-2-yl)-3-methylphenyl)isoxazole-3-carboxamide (18 mg, 24%). UPLC-MS (Acidic Method, 4 min): rt 2.01 min, m/z 320.1 [M+H]+ 1H NMR (400 MHz, DMSO-d6) d ppm 10.58-11.34 (m, 1H), 8.95-9.42 (m, 1H), 8.16 (br d, J=8.2 Hz, 1H), 7.65-8.01 (m, 4H), 7.27-7.56 (m, 2H), 7.07 (br d, J=1.8 Hz, 1H), 2.67-2.86 (m, 3H)

3209-71-0, The synthetic route of 3209-71-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JAGUAHR THERAPEUTICS PTE LTD; METE, Antonio; HITCHIN, James, R.; GRAHAM, Mark; (46 pag.)WO2020/43880; (2020); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

100499-66-9, 5-Methylisoxazol-4-amine hydrochloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(A-70) According to the method of the reference(J. Org. Chem. 1987, 52, p2714), (5-methylisoxazole-4-yl)amine hydrochloride(16.15g, 120mmol) was reacted with 4-fluorophenylacetyl chloride(20.8g, 120mmol) in the presence of triethylamine to give 2-(4-fluorophenyl)-N-(5-methylisoxazole-4-yl)acetamide(22.55g, yield:80%). NMR(CDCl3)delta: 2.28(3H, s), 3.69(3H, s), 6.71(1H, brs), 7.06-7.20(2H, m), 7.26-7.32(2H, m), 8.46(1H, s)., 100499-66-9

As the paragraph descriping shows that 100499-66-9 is playing an increasingly important role.

Reference£º
Patent; SHIONOGI & CO., LTD.; EP1422218; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1750-42-1,Isoxazol-3-amine,as a common compound, the synthetic route is as follows.

General procedure: The heterocyclic amines (1a-h, 10 mmol) were dissolved in 10 mL water followed by addition of 40 mL of 6M HCl and the systems were cooled in the ice-salt bath down to -10C. Afterwards, an aqueous solution of NaNO2 (10 mmol, 0.7g/5 mL H2O) was added slowly drop by drop and stirred vigorously on a magnetic stirrer. After 15 min, fresh solution of 4-hydroxycoumarin (3, 10 mmol, 1.62 g) in 10 mL NaOH (10 wt.) was added. Intensively colored and voluminous precipitates (4a-h) were obtained immediately which were stirred 15 min. in the bath and 30 min. on room temperature. Finally, they were filtrated by vacuum, washed 3 times with distilled water and dried on air. The purification was carried out by the technique of recrystallization using ethanol as solvent.

1750-42-1, As the paragraph descriping shows that 1750-42-1 is playing an increasingly important role.

Reference£º
Article; Jashari, Ahmed; Imeri, Faik; Ballazhi, Lulzime; Shabani, Agim; Mikhova, Bozhana; Draeger, Gerald; Popovski, Emil; Huwiler, Andrea; Bioorganic and Medicinal Chemistry; vol. 22; 9; (2014); p. 2655 – 2661;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14678-02-5,5-Amino-3-methylisoxazole,as a common compound, the synthetic route is as follows.

General procedure: A mixtureof CSA (23.2mg, 0.10mmol), 5-amino-3-methylisoxazole,(1.00mmol), isatin (1.00mmol), and -diketones(1.00mmol) in 5mL EtOH was irradiated with ultrasoundof low power at 70?C for the period of time indicated inScheme 2 and Table 3. After completion of the reaction, asindicated by TLC monitoring, the resultant solid was washedwith water and crystallized from ethanol to give productsa-d., 14678-02-5

As the paragraph descriping shows that 14678-02-5 is playing an increasingly important role.

Reference£º
Article; Pelit, Emel; Journal of Chemistry; vol. 2017; (2017);,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

4857-42-5, 3-Methylisoxazole-5-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1 (5g) in EtOH(100mL) was added thionyl chloride(3.44mL), and the resulting solution was stirred at 50 C. After termination of this reaction, the solution was cooled to room temp. and the volatile was removed under reduced pressure. The residue was dissolved in EtOAc and partitioned between Na2CO3 soln. and EtOAc, then extracted with EtOAc. The extraction was washed with water, brine and dried with MgSO4 and concentrated in vacuo to give ethylester(6.3g). To a solution of tetramethylammonium nitrate(6.81g) in CH2Cl2 (40mL)was added trifluoromethanesulfonic acid anhydride(8.41mL). Ethylester(5.17g) in CH2Cl2 (15ml)was added to the solution and the resulting mixture was refluxed overnight. The reaction mixture was cooled to room temp. and added sat. NaHCO3 soln., then partitioned between water and EtOAc and extracted with EtOAc. The extraction was washed with water and brine, dried with MgSO4 and concentrated in vacuo. The residue was purified by silicagel columnchromatography to give 16 (5.38g).

4857-42-5, As the paragraph descriping shows that 4857-42-5 is playing an increasingly important role.

Reference£º
Patent; SHIONOGI & CO., LTD.; EP1894919; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

19788-37-5, 4-(Chloromethyl)-3,5-dimethylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2,4-Dihydroxy-benzoic acid methyl ester (14) (1 g, 5.949 mmol) in DMF (2 mL), K2C03 (1.64 g, 11.898 mmol) and 4-Chloromethyl-3,5-dimethyl- isoxazole (4) (0.75 mL, 5.949 mmol) were added and the reaction was stirred at RT for 16 hours. The reaction mixture was diluted with ethyl acetate, washed with water and brine, dried over sodium sulfate and concentrated. The crude was purified by column chromatography (silica, gradient: 20-30% EtOAc in Hexane) to afford the Intermediate 15 (400 mg, 24%) as white solid., 19788-37-5

19788-37-5 4-(Chloromethyl)-3,5-dimethylisoxazole 88246, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; THE BROAD INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION; INSTITUTO CARLOS SLIM DE LA SALUD; BURNS, Sean, M.; WAGNER, Bridget, K.; VETERE, Amedeo; (189 pag.)WO2018/175324; (2018); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

123770-62-7, Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (prepared according to WO2010/142801, p. 147, 0.093 g) was dissolved in dichloromethane (5 ml) and 1,1′-carbonyldimidazole (0.089 g) was added. The reaction mixture was stirred for 2 h at room temperature before (2E,4E)-7-butoxyhepta-2,4-dien-1-amine hydrochloride (0.120 g) and triethylamine (0.076 ml) were added. The reaction mixture was warmed to 40C and stirred overnight after which it was cooled to room temperature and washed with water. The organic layer was collected and evaporated in vacuo. The crude product was purified via flash column chromatography to yield the product as a white solid

123770-62-7, The synthetic route of 123770-62-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dr. August Wolff GmbH & Co. KG Arzneimittel; Soeberdt, Michael; Knie, Ulrich; Abels, Christoph; EP2666766; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem