M.W=350-400 | Page 7 of 11 | Heterocyclic Building Blocks-isoxazole

Zhang, Yan’s team published research in Zhongguo Linchuang Yanjiu in 27 | CAS: 198470-85-8

Zhongguo Linchuang Yanjiu published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C6H17NO3Si, Computed Properties of 198470-85-8.

Zhang, Yan published the artcileObservation of parecoxib sodium combined with midazolam in prevention of restlessness after endoscopic surgery, Computed Properties of 198470-85-8, the publication is Zhongguo Linchuang Yanjiu (2014), 27(3), 316-318, database is CAplus.

Objective To observe the effect of parecoxib sodium combined with small dose of midazolam in prevention of restlessness after endoscopic surgery. Random 90 patients receiving general anesthesia for elective endoscopic sinus surgery were divided into P, PM, C groups with 30 cases in each group, and before the end of 30 min of endoscopic sinus surgery, P group was given i.v. parecoxib sodium 40 mg, PM group was given i.v. parecoxib sodium 40 mg + midazolam 0.02 mg/kg, and group C was given i.v. injection of saline. The breathing recovery time, eye opening time, extubation time; and MAP and HR values at extubation (T1) and 5 min (T2) after extubation and 10 min (T3) after extubation were detected, and the restlessness score (RS), Ramasay sedation score (RSS), and visual analog scale (VAS) at postoperative 6h, 12h and 24h were recorded. Results The MAP and HR values at T1-T3 were superior in PM group (P<0.05); RS, RSS and VAS values at different time points in PM group were lower than P group and C group (P<0.05); the breathing recovery time, eye opening time and extubation time had no difference among the three groups (P>0.05). There were 14 cases of nausea and 11 cases of vomiting in C group; 12 cases of nausea and 9 cases of vomiting in P group; 8 cases of nausea and six cases of vomiting in PM group; nausea and vomiting was similar among the three groups (P>0.05). Conclusion Parecoxib combined with low-dose midazolam anesthesia may be effective in preventing endoscopic surgery restlessness, and can be safely used for analgesia after endoscopic sinus surgery.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Tao, Guanghua’s team published research in Jianyan Yixue Yu Linchuang in 13 | CAS: 198470-85-8

Jianyan Yixue Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H8O3, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Tao, Guanghua published the artcileApplication of dexmedetomidine combined with parecoxib sodium in pulmonary lobectomy with one-lung ventilation, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Jianyan Yixue Yu Linchuang (2016), 13(23), 3348-3351, database is CAplus.

Objective: To investigate the effect of dexmedetomidine combined with parecoxib sodium on pulmonary inflammatory response in patients undergoing pulmonary lobectomy with one-lung ventilation. Methods: Eighty patients underwent pulmonary lobectomy with one-lung ventilation were randomly divided into dexmedetomidine group (group D, n = 20), parecoxib sodium group (group P, n = 20), dexmedetomidine combined with parecoxib sodium group (D + P group, n = 20) and saline control group (N group, n = 20). The groups were treated with normal saline, dexmedetomidine, parecoxib sodium and dexmedetomidine combined with parecoxib sodium, resp. Peripheral venous blood was taken from the patients, and levels of interleukin (IL)-1β, IL-6, cyclooxygenase-2 (COX-2), reactive oxygen species (ROS) at different time points were detected by ELISA immunoassay. Radial arterial blood was taken from the patients and analyzed, and the partial pressure of blood oxygen (PaO₂), partial pressure of carbon dioxide (PaCO₂) and oxygenation index were compared. VAS pain score and analgesic dose were recorded at 12 h and 24 h after surgery. Results: The expression of inflammatory factors in D + P group was significantly lower than that in other groups, and that of the D group and P group were significantly less than that of N group (P < 0.05). The blood gas anal. showed that PaO₂ and oxygenation index in the D + P group were higher than those of the N group, while PaCO₂ is lower, and there is no statistically significant difference between the P group and D group (P > 0.05). In comparison of VAS score and 24 h tramadol dosage, the D + P group had the lowest VAS score and tramadol dosage, which were significantly lower than those of the N group (P < 0.05). Conclusion: Dexmedetomidine combined with parecoxib sodium can reduce intraoperative pulmonary inflammatory response, improve oxygenation and reduce the dose of postoperative analgesics in patients undergoing pulmonary lobectomy with one-lung ventilation.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Xiong, Qiuju’s team published research in Chongqing Yike Daxue Xuebao in 42 | CAS: 198470-85-8

Chongqing Yike Daxue Xuebao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H13ClN2O, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Xiong, Qiuju published the artcileEfficacy of continuous lumbar plexus block combined with multimodal analgesia after revision hip arthroplasty, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Chongqing Yike Daxue Xuebao (2017), 42(5), 560-564, database is CAplus.

Objective: To compare the analgesic efficacy between the continuous lumbar plexus block (CLPB) combining with multimodal analgesia and patient controlled i.v. analgesia (PCIA) combining with multimodal analgesia after revision hip arthroplasty. Methods: Totally 68 patients for single side revision hip arthroplasty were equally divided into CLPB group and PCIA group. The parecoxib was used in both group 3 days before operation. The ropivacaine was used to analgesia through lumbar plexus catheterization in CLPB group, and the PCIA group with tramadol and flurbiprofen analgesia. All patients continued analgesia for 3 days. After operation, the parecoxib was used when visual analog scale (VAS) scores more than 3 scores in exercise state. The VAS scores at rest and exercise state were estimated The parecoxib dose by i.v. injection and the presses of the pump were recorded. And the complications were observed Results: The VAS pain scores of CLPB group during rest at different time points after revision hip arthroplasty were significantly lower than those of PCIA group (P<0.05). The VAS scores of CLPB during exercise at 6 h, 12 h, 24 h after revision hip arthroplasty were (2.50±0.71), (3.59±0.99), (3.67±1.01), which were significantly lower than those of (4.97±0.94) (P=0.00), (4.85±0.86) (P=0.00), (4.32±0.73) (P=0.00) in PCIA group at corresponding time points. In CLPB group, the parecoxib dose by i.v. injection and presses of the pump were fewer than that of PCIA group (0.05). And the side effects of CLPB group were fewer than those in PCIA group. Conclusion: CLPB combined with multimodal analgesia can alleviate the early pain of patients undergoing revision hip arthroplasty; the patients who received CLPB technique showed better pain relief, less complication than those who been given PCIA. Therefore, CLPB combined with multimodal analgesia should be considered a better analgesia method for patients after revision hip arthroplasty.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Niu, Fu-guo’s team published research in Hainan Yixueyuan Xuebao in 22 | CAS: 198470-85-8

Hainan Yixueyuan Xuebao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Niu, Fu-guo published the artcileEffect of preemptive analgesia with parecoxib sodium on the inflammatory cytokine and stress in puerpera after cesarean section, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Hainan Yixueyuan Xuebao (2016), 22(19), 2322-2324, 2328, database is CAplus.

Objective: To explore the effect of preemptive analgesia (PA) with parecoxib sodium on the inflammatory cytokine and stress in puerpera after cesarean section. Methods: A total of 70 pregnant women who were admitted in our hospital from May, 2015 to May, 2016 for cesarean section were included in the study and r andomized into the observation group and the control group with 35 cases in each group. A venous channel was established. The heart rate, blood pressure, and oxygen saturation were continuously monitored by the monitor. The patients in the observation group were i.v. injected with parecoxib sodium (40mg) and normal saline (2mL), while the patients in the control group were i.v. injected with normal saline (2mL) 30min before anesthesia induction. The venous blood when entering the operation room, after operation, 4h, 8h, and 12 hafter operation was extracted The plasma IL-6, TNF-α, P substance, E, and NE levels were detected. Results: IL-6 and TNF-α level after operation in the two groups were elevated, reached the peak 4hafter operation, and were gradually reduced 8hafter operation. IL-6 and TNF-α levels at each timing point after operation in the observation group were significantly lower than those in the control group (P < 0.05). P substance after operation in the two groups was elevated, reached the peak 4hafter operation, and was gradually reduced 8 h after operation. P substance level at each timing point after operation in the observation group was significantly lower than that in the control group (P < 0.05). N and NE levels after operation in the two groups were elevated, reached the peak 4h after operation, and were reduced to the levels when entering the operation time 12 hafter operation. N and NE levels at each timing point after operation in the observation group were significantly lower than those in the control group (P < 0.05). Conclusions: PA with parecoxib sodium in application of puerpera after cesarean section can effectively reduce the stress reaction, decrease the production of inflammatory cytokines, with a favorable analgesic effect, and further reduce the occurrence of postoperative complications.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Luo, Si-jia’s team published research in Zhongguo Xiandai Putong Waike Jinzhan in 20 | CAS: 198470-85-8

Zhongguo Xiandai Putong Waike Jinzhan published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Luo, Si-jia published the artcileEffect of oxycodone combined with parecoxib sodium on pain relief after laparoscopic cholecystectomy, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Zhongguo Xiandai Putong Waike Jinzhan (2017), 20(10), 814-815, 818, database is CAplus.

To explore the safety of oxycodone combined with parecoxib sodium in laparoscopic cholecystectomy. According to the random number table method, 102 patients who were to undergo laparoscopic cholecystectomy were divided into a control group and an observation group, with 51 cases in each group. The control group was anesthetized with morphine combined with parecoxib sodium. The observation group was anesthetized with oxycodone combined with parecoxib sodium. The pain conditions of the two groups of patients were evaluated at 3, 12, 24, and 48 h after the operation, and the number of PCA compressions and the addnl. analgesics in the two groups within 48 h after the operation were recorded. At 3, 12, 24, and 48 h after surgery, the difference in pain scores during resting and coughing between the two groups was statistically significant (P < 0.05). The number of effective PCA compressions and the addnl. rate of analgesic drugs in the observation group within 48 h after surgery were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions in the observation group was 11.8%, which was significantly lower than the 37.3% in the control group (P < 0.05). During laparoscopic cholecystectomy, the use of oxycodone combined with parecoxib sodium anesthesia can not only achieve better anesthesia and analgesia, but also reduce the occurrence of adverse reactions, thereby ensuring the safety of patients.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wang, Afang’s team published research in Yaowu Liuxingbingxue Zazhi in 25 | CAS: 198470-85-8

Yaowu Liuxingbingxue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H11BO2, Formula: C19H17N2NaO4S.

Wang, Afang published the artcileRetrospective analysis on the inhibiting effect of parecoxib sodium on the inflammatory factors and stress response in patients after hip and knee replacement surgery, Formula: C19H17N2NaO4S, the publication is Yaowu Liuxingbingxue Zazhi (2016), 25(3), 146-149, database is CAplus.

Objective: To evaluate the stress reaction and inflammatory factor inhibition effect of parecoxib sodium continuous pumped after hip and knee arthroplasty, and provide a reference for the orthopaedic perioperative analgesic solution Methods: 52 cases of total hip, semi hip and knee joint surface replacement patientsâ?clin. data were retrospectively analyzed, which divided into observation group and control group according to analgesic method, 26 cases in each group. The control group received bupivacaine for patient controlled epidural analgesia therapy after operation, patients in the observation group combined with parecoxib sodium i.v. injection pumped, 5 mg per h. The level of pain relief in different time points were observed The levels of plasma inflammatory factor, cortisol (Cor), and adrenocorticotropic hormone (Glu) were compared in the two groups. Results: The VAS score of observation group was lower than that of the control group in every time points (P<0.05). The 0 and I pain levels of IL-6 and IL-1Î² in the observation group were significantly higher than those in the control group (P>0.05). The levels of IL-6 and IL-1Î² were significantly different between two groups (Glu), and the levels of Cor and Glu were significantly lower in two groups (P<0.05). The index level of observation group were significantly lower than the control group (P<0.05). Conclusion: Parecoxib sodium continuous pumped could alleviate the pain of hip and knee replacement in patients with postoperative, reduce the levels of inflammatory factors and stress level, it was worth clin. promotion.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Hai-ying’s team published research in Shiyong Yaowu Yu Linchuang in 20 | CAS: 198470-85-8

Shiyong Yaowu Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, SDS of cas: 198470-85-8.

Li, Hai-ying published the artcileEffect of ulinastatin and parecoxib sodium on intrapulmonary shunt fraction during one lung ventilation, SDS of cas: 198470-85-8, the publication is Shiyong Yaowu Yu Linchuang (2017), 20(1), 30-34, database is CAplus.

Objective: To explore the effect of ulinastatin and parecoxib sodium on intrapulmonary shunt during one lung ventilation. Methods: One hundred patients receiving one lung ventilation treatment for esophageal cancer from Apr. 2014 to Apr. 2015 were involved as the observation objects. According to the patient preference, patients were divided into group A (n=50) and group B (n=50). The same induction of anesthesia and anesthesia drugs were given to them to maintain the same depth of anesthesia. Half an hour before anesthesia, 40 mg parecoxib sodium was given to group A, and 50 U UTI was given to group B. The mean airway pressure, heart rate, mean arterial pressure, oxygen saturation, arterial carbon dioxide partial pressure, pulmonary shunt fraction, interleukin (IL)-6, IL-8 Junior necrosis factor α and C-protein expression were compared at the following time points: after induction of anesthesia (S₁ period), 0.5 h after one-Lung ventilation (S₂ period), 1 h after one lung ventilation (S₃ period) and 0.5 h after restoring lung ventilation (S₄ period). Results: The mean arterial pressure of group A (77.9±11.5) was higher than that of group B (73.6±9.1) at the period of S₄, the difference was statistically significant (P<0.05). The arterial carbon dioxide tension of group A (41.4±3.8, 41.8±3.4, 41.7±2.8) was higher than that of group B (42.7±2.1, 42.7±2.1, 44.8±3.7) at the period of S₂, S₃ and S₄, the difference were statistically significant (P<0.05). The pulmonary shunt fraction of group A was lower than that of group B on the period of S₂ and S₃. The pulmonary shunt fractions of the two groups on the period of S₂ and S₃ were higher than those on the period of S₄. Conclusion: Parecoxib sodium and ulinastatin have protective effect on one lung ventilation, but parecoxib sodium reduces intrapulmonary shunt fraction more significantly which can avoid the damage to the lung tissue to some extent.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Chen, Wei’s team published research in Huaxi Yixue in 30 | CAS: 198470-85-8

Huaxi Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, COA of Formula: C19H17N2NaO4S.

Chen, Wei published the artcileEffects of parecoxib sodium preemptive analgesia on postoperative inflammatory cytokines and stress responses in elderly patients undergoing total hip replacement, COA of Formula: C19H17N2NaO4S, the publication is Huaxi Yixue (2015), 30(6), 1067-1070, database is CAplus.

Objective: To investigate whether parecoxib sodium preemptive analgesia reduces inflammatory cytokines and stress hormones production in elderly patients after total hip replacement. Methods: Sixty patients with American Society of Anesthesiologists Classification I-II undergoing total hip replacement for femoral neck fracture or aseptic necrosis of the femoral head, aged between 60 and 90 years with a body weight more than 50 kg, were randomly divided into preemptive analgesia group (group P, n = 30) and control group (group C, n = 30). The patients in group P received parecoxib sodium 40 mg i.v. 30 min before skin incision, and another 20 mg 8 h after the first administration. All the patients in the two groups received the administration of patient-controlled analgesia sufentanyl. We recorded blood levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), cortisol (COR), adrenaline (AD) and noradrenaline (NAD) 30 min before skin incision, and 1 h, 6 h, 12 h and 24 h postoperatively. Results: The blood levels of IL-6, TNF-α, COR, AD and NAD in group P at 1 h, 6 h, 12 h or 24 h postoperatively were significantly lower than those in group C (P<0.05). Conclusion: Parecoxib sodium preemptive analgesia reduces postoperative inflammatory cytokines and stress hormones production in elderly patients undergoing total hip replacement.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yang, Lihua’s team published research in Zhonghua Shiyan Waike Zazhi in 32 | CAS: 198470-85-8

Zhonghua Shiyan Waike Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C9H8BNO2, COA of Formula: C19H17N2NaO4S.

Yang, Lihua published the artcileInfluence of parecoxib sodium on stress, inflammatory response and postoperative analgesia in patients undergoing radical resection of esophageal cancer, COA of Formula: C19H17N2NaO4S, the publication is Zhonghua Shiyan Waike Zazhi (2015), 32(9), 2302-2303, database is CAplus.

Influence of parecoxib sodium on plasma Cor, β-EP, PGE2, TNF-α and IL-6 in patients undergoing radical resection of esophageal cancer was observed Sixty cases with radical resection of esophageal cancer were chosen and randomly divided into parecoxib sodium group (P) and control group (C). Plasma Cor, β-EP, PGE2, TNF-α and IL-6 were determined before induction (T1), 2 h during surgery(T2), end of surgery (T3), 12 h (T4), 24 h (T5), 48 h (T6) after surgery. Indexes in P group were significantly lower than those in C group. Parecoxib sodium could alleviate stress response, weaken peripheral and central sensitization and alleviate inflammatory response.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yang, Ting’s team published research in International Journal of Neuroscience in | CAS: 198470-85-8

International Journal of Neuroscience published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C25H29N9O3, Computed Properties of 198470-85-8.

Yang, Ting published the artcileEffects of rTMS combined with rPMS on stroke patients with arm paralysis after contralateral seventh cervical nerve transfer: a case-series, Computed Properties of 198470-85-8, the publication is International Journal of Neuroscience, database is CAplus and MEDLINE.

We conducted this study to evaluate the effect of rTMS combined with rPMS on stroke patients with arm paralysis after CSCNTS. A case-series of four stroke patients with arm paralysis, ages ranging from 39 to 51 years, that underwent CSCNTS was conducted. Patients were treated with 10 HZ rTMS on the contralesional primary motor cortex combined with 20 HZ rPMS on groups of elbow and wrist muscles for 15 days. The muscle tone of elbow flexor muscle (EFM), elbow extensor muscle (EEM), wrist flexor muscle (WFM) and flexor digitorum (FD) reduced immediately after operation followed by increasing gradually. After rehabilitation, the muscle tone of EEM and EFM reduced by 14% and 11%, resp. There was a 13% and 45% change ratio in WFM and FD. The numeric rating scale (mean = 5.75 ± 1.71) was significantly lower (mean = 3.25 ± 1.90, t = 8.66, p = .00). Grip and pinch strength (mean = 23.65 ± 4.91; mean = 4.9 ± 0.59) were significantly higher (mean = 34.63 ± 5.23, t = -61.07, p = .00; mean = 7.1 ± 0.73, t = -13.91, p = .00). The rehabilitation of stroke patients with arm paralysis after CSCNTS is a long, complicated process which includes great change of neuropathic pain, muscle tone, and muscle strength. In order to enhance the neural connection between the contralesional hemisphere and the hemiplegic limb, alleviate postoperative complications, as well as accelerate the rehabilitation process, we can consider to use rTMS combined with rPMS.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem