Tag: M.W=350-400

Ren, Lei published the artcileEffect of celecoxib combined with parecoxib sodium for preemptive analgesia after lumbar fusion surgery, Safety of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Hebei Yixue (2017), 23(8), 1352-1356, database is CAplus.

Objective: To observe the effect of celecoxib combined with parecoxib sodium for preemptive analgesia in the treatment of early pain after lumbar fusion surgery. Methods: Between Nov. 2015 and June 2016, 105 patients who were planned to undergo posterior lumbar fusion were excluded from the history of peptic ulcer and coronary heart disease (35 cases of lumbar spinal stenosis, 50 cases of lumbar disk herniation, 20 cases of degenerative lumbar spondylolisthesis) were randomly divided into 3 groups with 35 persons in each group. Group A was given postoperative celecoxib + patient controlled analgesia (patient controlled analgesia, PCA) group, group B was postoperative parecoxib sodium + PCA pump group, and group C was celecoxib combined with parecoxib sodium + PCA pump for perioperative preemptive analgesia. There were no significant differences in disease distribution, gender, age, or weight among the three groups (P > 0.05). All patients underwent general anesthesia for tracheal intubation, posterior laminar decompression, intervertebral bone graft fusion, and pedicle screw internal fixation. The three groups of patients were given the corresponding medication regimen according to the grouping situation, and was administered with fentanyl for PCA after the operation. The observation indicators were the visual analog score, the dosage of analgesic pump drugs, and the incidence of adverse reactions such as nausea, vomiting, and constipation. Results: The postoperative analgesic effect of group C is better than that of group A and group B. The dosage of fentanyl in group C was less than that in group A and group B. The incidence of adverse reactions in group C was significantly lower than that in group A. There was no significant difference in the incidence of adverse reactions in group B and C. Conclusion: The preemptive analgesia of celecoxib combined with parecoxib sodium for early postoperative pain after lumbar posterior fusion surgery is better, and the analgesic effect is better than that of celecoxib or parecoxib sodium alone. It can reduce the amount of opioids, while reducing the incidence of adverse reactions.

Hebei Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Safety of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Huang, Saisai published the artcileEffect of parecoxib sodium on IL-6 and angiotensin II of knee surgery patients, Quality Control of 198470-85-8, the publication is Jiangsu Yiyao (2016), 42(8), 956-958, database is CAplus.

Effect of parecoxib sodium on IL-6 and angiotensin II of knee surgery patients was studied. 38 Knee surgery patients were divided into two groups, treatment group with parecoxib sodium, control group with NS. IL-6 and A-II were detected at before anesthesia T0, 0.5 h after begin T1, 1.5 h T2, ending T3. IL-6 nd A-II of T1-T3 were higher than T0, which of treatment group were lower than control group. Parecoxib sodium improved inflammation of knee surgery.

Jiangsu Yiyao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Quality Control of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yang, Ling-ling published the artcileObservation on effect of parecoxib sodium for analgesia before operation on recovery period of patients undergoing remifentanil fast-track anesthesia, HPLC of Formula: 198470-85-8, the publication is Xiandai Zhenduan Yu Zhiliao (2016), 27(21), 4052-4053, database is CAplus.

A total of 58 patients undergoing laparoscopic cholecystectomy were selected and divided into a study group and a control group with 29 cases each. The study group received parecoxib sodium injection 20 min before surgery, and the control group received normal saline injection 20 min before surgery. The postoperative analgesic response of the two groups of patients was compared. Results The average arterial pressure and heart rate levels in the study group were lower than those in the control group at 5, 10, 15 and 30 min after extubation, and the difference was statistically significant (P < 0.05). The VAS score and restlessness score of the study group were significantly lower than those of the control group, and the difference was statistically significant (P < 0.05). In contrast, the Ram-say sedation score of the study group was significantly higher than that of the control group, and the difference was statistically significant (P < 0.05). The preoperative application of parecoxib sodium for analgesia has a pos. impact on the postoperative recovery effect of remifentanil fast-track anesthesia patients, can relieve the patients′ pain and other stress responses, and ensure the safety of patients′ anesthesia, which is worthy of promotion.

Xiandai Zhenduan Yu Zhiliao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C6H17NO3Si, HPLC of Formula: 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Luo, Xi published the artcileAnalgesic effect of different dosage of Flurbiprofen axetil in laparoseopic cholecystectomy in comparison with other analgesic drugs, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Pakistan Journal of Pharmaceutical Sciences (2017), 30(5), 1895-1898, database is CAplus.

Flurbiprofen axetil is a non-selective cyclooxygenase inhibitor. It can target the aggregation with lipid micro sphere as drug carrier. and exert analgesic effect in surgical incision and inflammatory site. In laparoscopic cholecystectomy comparative study on analgesic effect of parecoxib and flurbiprofen axetil is relatively less. Therefore. this paper is mainly based on the observation of patients after resting VAS score. adverse reaction time and movement. to evaluate the analgesic effect of different drug dose of flurbiprofen and parecoxib sodium. which provides reference for clin. medication. The results show that the i.v. injection of parecoxib could provide effective analgesic effect in laparoscopic cholecystectomy. Also. compared with flurbiprofen. parccoxib shows a more significant analgesic effect.

Pakistan Journal of Pharmaceutical Sciences published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Chang-liang published the artcileGradient elution HPLC for related substances in parecoxib sodium for injection, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Zhongnan Yaoxue (2014), 12(3), 268-270, database is CAplus.

An HPLC method was developed to determine the relevant substances in parecoxib sodium for injection. An Agilent C₁₈ column (150 mm 脳 4.6 mm, 5 渭m) was used with gradient elution. The flow-rate was 1 mL 路 min^-1. The detection wavelength was 214 nm. Parecoxib and the adjacent impurities were effectively separated The sample solution was stable in 12 h at the room temperature The average recoveries low, middle and high concentration of valdecoxib was 100.2%, 100.3% and 99.4%. The method is accurate, reliable and reproducible, and can be used for the quality control of the preparation

Zhongnan Yaoxue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Lin, Jin-bing published the artcileEffect of parecoxib sodium on intravenous analgesic effect of dezocine after cesarean section, Computed Properties of 198470-85-8, the publication is Guangdong Yixue (2017), 38(7), 1098-1100, database is CAplus.

Objective: To observe the effect of parecoxib sodium on the analgesic effect of dezocine after cesarean section and its adverse reactions. Methods: 80 patients with ASA I-II grades combined spinal-epidural anesthesia who underwent voluntary postoperative analgesia after cesarean section were divided into parecoxib sodium group (P group) and control group (C group) according to the random number table, 40 cases in each. After the fetus was delivered, group P received i.v. injection of parecoxib sodium 40 mg, and group C received i.v. injection of the same amount of normal saline. After the operation, self-controlled i.v. analgesia with dezocine was used, and the analgesic solution was dezocine 0.5 mg /kg + normal saline to 100 mL. Adopt LCP mode of administration was used: loading dose (dezocine 5 mg) + maintenance dose 2.0 mL/h + single PCA dose 1 mL, lock-in time 15 min. The visual analog (VAS) pain scores at 2, 4, 8, 12, and 24 h after the operation of the parturient were recorded. The degree of uterine contraction pain within 24 h after the operation was recorded, and the satisfaction of the parturient鈥瞫 analgesia and overall adverse reaction rate were compared. Results: The VAS scores of the incision at 8 and 12 h in the P group were significantly lower than those in the C group (P < 0.05). The degree of postoperative uterine contraction pain in group P was significantly lower than that in group C (P < 0.05). The overall satisfaction of analgesia in group P was significantly higher than that in group C (P < 0.05). There was no significant difference in the incidence of overall adverse reactions between the two groups (P > 0.05). Conclusion: Parecoxib sodium can enhance the effect of dezocine for i.v. patient-controlled analgesia after cesarean section, reduce the degree of uterine contraction pain, and improve women鈥瞫 satisfaction without increasing adverse reactions.

Guangdong Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Computed Properties of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhang, Zi-Qi published the artcileEnantioselective Copper-Catalyzed 1,5-Cyanotrifluoromethylation of Vinylcyclopropanes, Application In Synthesis of 182122-10-7, the publication is Organic Letters (2019), 21(20), 8256-8260, database is CAplus and MEDLINE.

A copper-catalyzed enantioselective 1,5-cyanotrifluoromethylation of vinylcyclopropanes has been developed using a radical relay strategy. This asym. reaction has demonstrated high enantioselective control, broad substrate scope, and mild conditions. Initiated by the in situ generated CF₃ radical from Togni’s reagent, this method offers a new solution for remote enantioselective bifunctionalization of alkenes and thus provides a straightforward way for the synthesis of chiral CF₃-containing internal alkenylnitriles.

Organic Letters published new progress about 182122-10-7. 182122-10-7 belongs to isoxazole, auxiliary class BOX or PyBox,BOX or PyBox, name is (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), and the molecular formula is 0, Application In Synthesis of 182122-10-7.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhao, Ling published the artcileEfficacy of intravenous injection of parecoxib sodium combined with ropivacaine incision infiltration in postoperative analgesia of transsphenoidalsellar tumor resection, SDS of cas: 198470-85-8, the publication is Sichuan Yixue (2017), 38(4), 398-401, database is CAplus.

Objective: To observe the post-operative analgesia effect and safety of i.v. injection of parecoxib sodium combined with ropivacaine incision infiltration in transsphenoidalsellar tumor resection. Methods: 80 cases of patients undergoing elective transsphenoidalsellar tumor resection were randomly divided into 4 groups (n=20) with a prospective, randomized, controlled and double-blind method. Group A received 10 mL placebo for i.v. injection and 2 mL placebo for local incision infiltration. Group p was treated with 40 mg parecoxib sodium for i.v. injection and 2 mL placebo for local incision infiltration. Group L were given 10 mL placebo for i.v. and 2 mL 1% ropivacainefor local incision infiltration. And group PL were treated with 40 mg parecoxib sodium for i.v. injection and 2 mL 1% ropivacaine for local incision infiltration. After operation, the VAS score at 6^th hour, 12^th hour, 24^th hour, 36^th hour and 48^th hour, analgesia satisfaction of patients and the number of patients with 2% lidocaine nasal drops for rescue analgesia were recorded. Adverse reaction including skin itching, nausea, vomiting, adverse cardiovascular events and local anesthetics poisoning were observed Results: The VAS score within 24 h of group A was higher than other three groups (P<0.05). The VAS score at 6^th hour after operation of group PL was lower than that of Group P (P<0.05). The VAS score at 12^th hour and 24^th hour after operation of group PL were lower than those of Group L (P<0.05). There were no significant difference in side effect between group PL and other three groups (P>0.05). Conclusion: It is effective and safe to adopt i.v. injection of parecoxib sodium combined with ropivacaine incision infiltration in postoperative analgesia of transsphenoidalsellar tumor resection.

Sichuan Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H5F3N4, SDS of cas: 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wang, Guo-qiang published the artcileEffect of parecoxib sodium on secondary damage stimulation of patients with clavicular fracture, Related Products of isoxazole, the publication is Chongqing Yixue (2014), 43(23), 3076-3078, database is CAplus.

The aim of this paper is to investigate effect of parecoxib sodium on secondary damage stimulation of patients with clavicular fracture. Sixty patients with age 18-45 years were divided into parecoxib sodium group receiving parecoxib sodium before surgery and control group. MAP, HR, VAS and Cor at different time points were recorded, IL-6 concentration at different time points were detected and untoward effects were observed Compared with group C, MAP, HR, VAS and Cor in parecoxib sodium group decreased significantly (P<0.05) at time points T₁-T₆, and IL-6 concentration decreased at time points T₄-T₆, (P<0.05). The untoward effect rate and administration times were lower than control group (P<0.05). During surgery for clavicular fracture, parecoxib sodium can relieve pain, and inhibit body stress and inflammation reaction. Parecoxib sodium can inhibit pain sensitization induced by secondary damage stimulation (surgery).

Chongqing Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H6ClN, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Xiuze published the artcileParecoxib sodium pretreatment reduces myoclonus after etomidate: a prospective, double-blind, randomized clinical trial, Category: isoxazole, the publication is International Journal of Clinical Pharmacology and Therapeutics (2017), 55(7), 601-605, database is CAplus and MEDLINE.

Objective: Myoclonus induced by etomidate during induction of general anesthesia is a common phenomenon. This prospective, randomized, saline-controlled clin. study was performed to evaluate the effect of parecoxib sodium pretreatment on the incidence and severity of etomidate induced myoclonus. Methods: 60 patients, American Society of Anesthesiologists (ASA) phys. status I or II, aged 20 to 60 years, who were scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia, were allocated randomly into one of two groups to receive parecoxib sodium 40 mg i.v. (group P, n = 30) or the same volume of saline (group S, n = 30) 30 min before administration of etomidate (0.3 mg/kg). Myoclonus was assessed on a scale of 0 – 3. Postoperative side effects were recorded. Results: The two groups were comparable with regard to baseline characteristics. The incidence of myoclonus was significantly lower in the parecoxib sodium group (11/30; 37%) than in the saline group (21/30; 70%) (p < 0.05). The severity of myoclonic movements was also significantly reduced by parecoxib sodium (p < 0.05). There were no significant differences between the two groups with respect to postoperative side effects. Conclusions: Pretreatment with i.v. injection of parecoxib sodium 40 mg significantly reduced the incidence and severity of etomidate- induced myoclonus without significant side effects.

International Journal of Clinical Pharmacology and Therapeutics published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem