Tag: M.W=350-400

Zhang, Lei published the artcileAnalgesic effect of parecoxib sodium on anterior cruciate ligament reconstruction under arthroscopy and its effect on inflammatory factors, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Chongqing Yixue (2014), 43(33), 4532-4534, database is CAplus.

The aim is to study analgesic effect of parecoxib sodium on anterior cruciate ligament reconstruction under arthroscopy and its effect on inflammatory factors. By randomized controlled trial, 40 cases of anterior cruciate ligament reconstruction under arthroscopy were enrolled and divided into 2 groups: group A, i.v. injection of 40 mg parecoxib sodium 30 min before skin incision; group B, i.v. injection of 40 mg parecoxib sodium 30 min after skin incision. After reconstruction, both groups took PCIA pump with tramadol hydrochloride for analgesia. The VAS score and dosage of tramadol hydrochloride were compared at different time points before and after reconstruction. The serum IL-6 and IL-8 levels were also compared 30 min before skin incision(T1), 8 h after reconstruction(T2). 2 H after reconstruction, there was no statistic difference in VAS for both groups. But 8, 12 and 24 h after reconstruction, the VAS score in group B was obviously higher than that in group A. Group A took obviously less tramadol hydrochloride than group B. Result showed that the parecoxib sodium had better effect on anterior cruciate ligament reconstruction under arthroscopy and inflammatory factors.

Chongqing Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C6H5N3S, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yan, Bing published the artcileEffect of parecoxib sodium on postoperative cognitive function in elderly patients with general anesthesia, Synthetic Route of 198470-85-8, the publication is Xiandai Zhenduan Yu Zhiliao (2016), 27(11), 2024-2026, database is CAplus.

Objective To study the effect of parecoxib sodium on postoperative cognitive function in elderly patients with general anesthesia. Methods 82 Patients for elective gastrointestinal surgery from Feb. 2014 to Feb. 2015 were randomly divided into a control group (41 cases) and an observation group (41 cases). Patients in both groups were routinely anesthetized, and after induction, 2-2.5% sevoflurane was inhaled to maintain anesthesia, rocuronium and sufentanil were injected i.v. at the same time, and propofol was continuously injected to maintain anesthesia. After surgery, the control group received i.v. injection of sodium chloride solution 2mL at 0.5h after surgery, the observation group received i.v. injection of parecoxib sodium 40mg + sodium chloride solution 2ml. Before and after the operation, the MMSE was used to evaluate the cognitive function status of the two groups, and the changes in vital signs before and after surgery were monitored, and the occurrence of adverse reactions was recorded. Results There was no significant difference in the cognitive function scores of the two groups before and 2, 5, and 7 days after the operation (P > 0.05), and the systolic blood pressure, diastolic blood pressure, heart rate and blood oxygen saturation of the two groups before and 2, 5, and 7 days after the operation were not statistically significant (P > 0.05). The incidence of adverse reactions in the observation group (12.20%) was slightly lower than that in the control group (17.07%), but the difference was not statistically significant (P > 0.05). Conclusion Parecoxib sodium has no significant influence on postoperative cognitive function in elderly patients with general anesthesia, and has good safety.

Xiandai Zhenduan Yu Zhiliao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C44H58NO5PPdS, Synthetic Route of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhu, Yulin published the artcileEffect of different-time administration of parecoxib sodium on emergence agitation in patients underwent gynecological laparoscopic surgeries during general anesthesia recovery period, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Sichuan Yixue (2016), 37(1), 74-76, database is CAplus.

Objective: To investigate the effect of parecoxib sodium i.v. injection in different time on the emergence agitation (EA) in patients with gynecol. laparoscopic surgeries. Methods: Sixty patients of ASA phys. status 1 or 11, scheduled for gynecol. laparoscopic surgeries under general anesthesia were randomized into two groups, parecoxib sodium group I (group A) and parecoxib sodium group II (group B). Group A were i.v. injected parecoxib sodium 30 mg 30 min prior to the operation and Group B received the same dose but 30 min before the end of the operation. Blood pressure (BP), heart rate (HR), postoperative pain and emergence agitation were observed and recorded immediately (T₀), 5 min (T₁), 10 min (T₂) and 20 min (T₃) after the operation. Variation of blood pressure and heart rate from T₀ to T₂ from T₀ to T₂ were compared as well. Results: Higher blood pressure and heart rate were observed in both of the two groups at T₂, with statistic significance (P < 0.05). And blood pressure and heart rate change from T₀ to T₂, emergence agitation and pain score in group A had an obvious improvement compared to group B (P < 0.05). Conclusion: I.v. injection of parecoxib sodium before the operation has a significantly better efficacy on decreasing emergence agitation in gynecol. patients undergoing laparoscopic surgeries.

Sichuan Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H5F3O3, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Xie, Rong published the artcileObserving the analgesic effect of parecoxib sodium in hepatic carcinoma radiofrequency ablation surgery via premedication, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Jiangsu Daxue Xuebao, Yixueban (2014), 24(2), 172-173, 176, database is CAplus.

The objective was to observe the analgesic effect of parecoxib sodium in hepatic carcinoma radiofrequency ablation surgery via premedication. The method includes enrolling 40 patients will receive hepatic carcinoma radiofrequency ablation surgery, randomly dividing them into parecoxib sodium group and control group, i.v. injection of parecoxib sodium 1 mg/kg to the patients in parecoxib sodium group 30 min before anesthesia induction, i.v. injection of physiol. saline to the control group, observing blood pressure, heart rate, blood oxygen saturation degree and breathing rate before anesthesia induction, at the point of puncture needle into skin, at the point of puncture needle into capsula fibrosa and at the end of the surgery, and recording to the VAS and untoward effect. The results show that parecoxib sodium used before hepatic carcinoma radiofrequency ablation surgery can alleviating the postoperative pain.

Jiangsu Daxue Xuebao, Yixueban published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C39H35N5O8, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Jin, Chao published the artcileCurative effect of parecoxib sodium applied at different preemptive analgesia time points on laparoscopic cholecystectomy, Related Products of isoxazole, the publication is Yaowu Liuxingbingxue Zazhi (2015), 24(1), 9-11, database is CAplus.

Objective: To discuss curative effect and security of parecoxib sodium applied on laparoscopic cholecystectomy (LC). Methods: 68 Cases of patients undergoing LC were randomly divided into observation group and control group. The patients in two groups were given LC by general anesthesia tracheal intubation, which were given remifentanil after the operation. The patients in observation group were given parecoxib sodium 40 mg iv before anesthesia induction, as well as 0.9% sodium chloride injection (NS) 2 mL iv upon the completion of operation, while the patients in control group were given 2 mL NS iv before anesthesia induction, as well as parecoxib sodium 40 mg upon the completion of operation. The visual analog scales (VAS) of patients in two groups were observed at the following time points: 1 h (T₁), 2 h (T₂), 8 h (T₃), 12 h (T₄) and 24 h (T₅) after the operation. The PCIA and adverse drug reactions in two groups were observed Results: The VAS of patients in observation group at T₁, T₂, T₃, T₄ and T₅ were better than those in control group (P < 0.05). The PCIA press times and effective press times of patients in observation group within 24 h after the operation were much less than those in control group (P < 0.05). There were no statistically significant difference between the occurrence rates of adverse drug reactions of patients in the two groups (P > 0.05). Conclusion: The application of parecoxib sodium preemptive analgesia before the anesthesia induction can receive favorable VAS effect, which can reduce the use frequency of postoperative analgesia pump, and is safe and effective.

Yaowu Liuxingbingxue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Ding, Xian published the artcileEffects of early use of parecoxib sodium on serum TNF-α in mice with burn, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Jiangsu Yiyao (2015), 41(21), 2514-2516, C2, database is CAplus.

Objective To observe the effects of early use of parecoxib sodium on serum tumor necrosis factor-α(TNF-α) in mice with burn. Methods Two hundreds ICR male mice were randomly divided into 4 groups with 50 mice each. At 4 h after the burn models were established, the mice were i.p. injected with normal saline (group IU), parecoxib sodium 0.75 mg/kg (group TA) or parecoxib sodium 7.5 mg/kg (group TB), which was repeated at 24 and 48 h after the first injection. The mice without burn were taken as the controls (group U). Serum levels of TNF-α were detected by CBA liquid chip method at 6(T1), 12(T2), 24(T3), 48(T4) and 72 h (T5) after the first injection. Results Compared with group U, serum concentration of TNF-α in group IU at each time point was increased significantly (P<0.05). Serum level of TNF-α at T1 were higher in group TA than that in group U (P<0.05). Serum levels of TNF-α at T2-T5 were lower in group TB than those in group U (P<0.05). Serum levels of TNF-α at T2-T5 in group TA and at T1-T5 in group TB were lower than those in group IU (P<0.05). Conclusion The application of parecoxib sodium 0.75 mg/kg in the early stage of burn can moderately decrease serum concentration of TNF-α, which is beneficial to inhibiting inflammation in mice with burn. But the use of parecoxib sodium 7.5 mg/kg may decrease serum concentration of TNF-α excessively, which is not beneficial to keeping the rebalance of proinflammatory cytokines and anti-inflammatory cytokines.

Jiangsu Yiyao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Guo, Yufeng published the artcileEffect of parecoxib sodium preemptive analgesia on postoperative cognition and inflammatory cytokines in elderly patients, Quality Control of 198470-85-8, the publication is Zhongguo Jiceng Yiyao (2016), 23(5), 683-686, database is CAplus.

Objective To study the effect of parecoxib sodium preemptive analgesia on the postoperative cognition and inflammatory cytokines in elderly patients. Methods Sixty elderly male patients undergoing replacement of total hip were randomly divided into two groups: the control group (group C, 30 cases) and the parecoxib sodium group (group P, 30 cases). In group C, physiol. saline 5 mL was injected after induction of anesthesia. Parecoxib sodium 40 mg was injected after induction of anesthesia in group P. Peripheral venous blood was collected at the following time pt: 2 h before operation (T₀), and 4 h (T₁), 24 h (T₂) and 48 h (T₃) after operation. And the serum concentrations of IL-1β, IL-6, tumor necrosis factor α (TNF-α) were measured by enzyme linked immunosorbent assay (ELISA). Cognitive function was assessed by mini-mental state examination (MMSE) at the time of T₀-T₃. Results The MMSE scores in group P [(25.4±0.6) points, (27.2±0.1) points, (27.2±0.1) points] were significantly higher than those in group C at T₁ and T₂. The concentrations of IL-1β, IL-6 and TNF-α in group P [T₁: (18.43±4.45) pg/mL, (165.34±9.57) pg/mL, (34.43±3.83) pg/mL; T₂: (14.59±2.59) pg/mL, (98.99±7.28) pg/mL, (22.32±3.81) pg/mL] were lower than those in group C [T₁: (23.97±3.85) pg/mL, (204.19±12.44) pg/mL, (37.77±4.81) pg/mL; T₂: (19.33±3.18) pg/mL, (121.35±9.67) pg/mL, (29.01±3.39) pg/mL] at T₁, T₂. The concentrations of IL-1β, IL-6 and TNF-α and the MMSE scores had no differences in group P and group C at T₃. The concentrations of IL-1β, IL-6 and TNF-α in group P at T₁ and T₂ [(9.57±2.24) pg/mL, (46.15±6.18) pg/mL, (14.48±3.14) pg/mL] were lower than those at T0, and had no difference at T₃. Conclusion Parecoxib sodium preemptive can reduce the incidence of POCD in elderly patients by inhibiting the release of early postoperative pro-inflammatory cytokines.

Zhongguo Jiceng Yiyao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Quality Control of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem