Tag: M.W=350-400

He, Lijiang published the artcileEfficacy analysis of parecoxib sodium in postoperative analgesia of thoracolumbar fractures, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Fujian Yiyao Zazhi (2014), 36(4), 113-114, database is CAplus.

Objective: To observe the clin. efficacy of parecoxib sodium in thoracolumbar fracture postoperative analgesia. Methods: 52 cases of patients with posterior decompression internal fixation surgery of general anesthesia after single thoracolumbar vertebral fracture were randomly divided into group A and group B. A group was given i.v. parecoxib sodium injection 40 mg after surgery, and group B for i.m. injection tramadol 100 mg. The onset time, visual analog pain scores, and adverse reactions at each time point of two groups were compared. Results: A group had analgesic onset time (11.36 ± 5.63) min, group B had analgesic onset time (17.27 ± 8.75) min, and the difference was statistically significant (P < 0.05). At each point visual analog analgesia score of A group was lower than that of group B, and A group had better analgesic effect (P < 0.05). The group A had better incidence of adverse reactions than group B (P < 0.05). Conclusion: Parecoxib sodium can effectively alleviate the thoracolumbar fracture postoperative pain, and is appropriate medication for i.v. analgesia.

Fujian Yiyao Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Feng, Dapeng published the artcileEffects of parecoxib sodium on prevention of emergence agitation during the recovery period of general anesthesia for the patients undergoing epigastric surgeries, Formula: C19H17N2NaO4S, the publication is Guoji Mazuixue Yu Fusu Zazhi (2014), 35(7), 613-616, database is CAplus.

The objective of this paper was to observe the preventive effects of parecoxib sodium on occurrence of emergence agitation during the recovery period of general anesthesia for the patients who underwent epigastric surgeries. One hundred and twenty patients, ASA I∼II, undergoing elective epigastric surgeries were divided randomly into four groups, with 30 cases in each group. Anesthesia of all patients was maintained with sevoflurane and remifentanil, keeping the bispectral index (BIS) around 40-50. Parecoxib sodium 0.8 mg/kg was i.v. infused into the patients just before anesthesia induction in group A and just before the closure of peritoneum in group B, sufentanil 0.08μg/kg was injected just before the closure of peritoneum in group C, and 2 mL saline as placebo was administrated in group D. The level of agitation(RS), visual analog scales(VAS) and ramsay sedation score(RSS) were evaluated during the recovery period of general anesthesia. Mean arterial pressure(MAP) and heart rate(HR) were monitored at preinduction (T1), 10 min before tracheal extubation (T2), immediately after tracheal extubation (T3) and 10 min after tracheal extubation (T4). The recovery times of group A, B, D(7±3), (8±4), (7±3) min were significantly shorter than those of group C. Requirement of remifentanil in group A (0.8±0.3) mg was significantly lower than that of group D (1.3±0.5) mg (P<0.05). At T3, the MAP and HR in group D(126±25) mmHg(1 mmHg=0.133 kPa) (106±28) beats/min were significantly higher than those in group A[(106±25) mmHg, (96±25) beats/min], group B [(113±27) mmHg, (99±27) beats/min], group C [(111±27) mmHg, (86±19) beats/min](P<0.05), which happened similarly at T4. Compared with group D, the incidence of agitation (33.3%) was significantly higher than that of group A (6.7%), group B (13.2%) and group C (10.0%) (P<0.05), and the incidence of agitation group A was significantly lower than group B (P<0.05). Compared with group D, the median of score of VAS was 5, which was significantly higher than that of group A (2), group B (3), and group C (2) (P<0.05). Compared with group D, the median of score of RSS was 4, which was significantly higher than that of group A (3), group B (3) and group C (3) resp. (P<0.05). The incidence of nausea and vomiting of group C was much higher than other groups significantly (P<0.05). Parecoxib sodium had analgesic effect for the patients of epigastric surgeries, preventing the incidence of postoperative agitation and adverse reactions during the recovery period of general anesthesia.

Guoji Mazuixue Yu Fusu Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Ni, Kai published the artcileEffects of flurbiprofen axetil and parecoxib sodium on postoperative pain and serum inflammatory stress indexes in patients with radical cervical cancer surgery, COA of Formula: C19H17N2NaO4S, the publication is Zhongguo Fuyou Baojian (2021), 36(5), 994-997, database is CAplus.

Objective To investigate the effects of flurbiprofen axetil and parecoxib sodium on postoperative pain and serum inflammatory stress indexes in patients with radical cervical cancer surgery. Methods cervical cancer 124 patients with radical operation from Dec. 2016 to Jan. 2019 in the hospital were divided into flurbiprofen axetil group (group A, 62 cases) and parecoxib sodium group (group B, 62 cases) according to random number table. Drugs are dissolved in 100mL of normal saline, analgesia was administered twice when the incision was closed and 12 h after the operation. The number of effective compressions, the dosage of sufentanil and the occurrence of adverse reactions at 24 h after operation were compared. The changes of serum inflammatory stress indexes before and after operation were compared between the two groups. Results The patients in group A were compared at 2 h, 6 h VAS score was significantly lower than that in group B (P<0.05), and the VAS score at 12h, 18h and 24h after surgery was higher than that in group B (P<0.05). The serum levels of TNF-α, IL-6, IL-8 and PCT in group B after surgery, 12h and 24h after surgery were significantly lower than those in group A (P<0.05). The effective compression times of PCIA in group B and the dosage of sufentanil in group B were significantly lower than those in group A (P<0.05). The total incidence of postoperative adverse reactions in group B was 11.29%, slightly lower than 16.13% in group A patients (P<0.05). Conclusion Flurbiprofen axetil and parecoxib sodium Both can significantly reduce postoperative pain in patients with radical resection of cervical cancer, and parecoxib sodium can reduce postoperative serum inflammatory response in patients.

Zhongguo Fuyou Baojian published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, COA of Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Masoudi-Sobhanzadeh, Yosef published the artcileTrader as a new optimization algorithm predicts drug-target interactions efficiently, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Scientific Reports (2019), 9(1), 1-14, database is CAplus and MEDLINE.

Several machine learning approaches have been proposed for predicting new benefits of the existing drugs. Although these methods have introduced new usage(s) of some medications, efficient methods can lead to more accurate predictions. To this end, we proposed a novel machine learning method which is based on a new optimization algorithm, named Trader. To show the capabilities of the proposed algorithm which can be applied to the different scope of science, it was compared with ten other state-of-the-art optimization algorithms based on the standard and advanced benchmark functions. Next, a multi-layer artificial neural network was designed and trained by Trader to predict drug-target interactions (DTIs). Finally, the functionality of the proposed method was investigated on some DTIs datasets and compared with other methods. The data obtained by Trader showed that it eliminates the disadvantages of different optimization algorithms, resulting in a better outcome. Further, the proposed machine learning method was found to achieve a significant level of performance compared to the other popular and efficient approaches in predicting unknown DTIs. All the implemented source codes are freely available at https://github.com/LBBSoft/Trader.

Scientific Reports published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Pradhan, Ujal published the artcileRisk predictive tools of perioperative drug hypersensitivity reaction: A case-control study, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is PLoS One (2022), 17(1), e0262362, database is CAplus and MEDLINE.

We aimed to determine the risk factors of perioperative drug hypersensitivity reaction (DHR) and develop a predictive score for use in clin. practice. A case-control study was conducted in patients who underwent anesthesia at a tertiary hospital in Thailand, between 2015-2018. DHR cases were graded clin. from 1 to 4 according to the World Federation of Societies of Anesthesiologists by two anesthesiologists. Controls were randomly matched with cases (ratio 2:1) by age group and month and type of surgery. Patient and anesthesia-related factors and agents given intraoperatively were recorded. A risk score was derived from the coefficients of the significant predictors of the final multivariate logistic regression model. Risk scores, adjusted odds ratios (OR) for perioperative DHR and 95% confidence intervals (CI) were determined Overall, 325 cases and 650 controls were recruited. The severity of DHR was grade 1 (72.9%), grade 2 (24%), and grade 3 (3.1%). Our risk predictive tools for perioperative DHR provided a sensitivity of 62% and specificity of 65%. Predictive scores of subgroups of moderate to severe DHR showed high specificity (80%) but low sensitivity (47%). Common predictors of overall DHR and moderate to severe DHR were history of drug allergy to 2 or more drug categories (score 2.5-3.5), being allergic to analgesics (score 2.5-4.0), and intraoperative morphine use (score of 1). The sole predictor of high-risk perioperative DHR (score ≥3.5) was airway management with an endotracheal tube intubation (OR 5.6, 95% CI 2.2-14.4) whereas history of allergic rhinitis (OR 11.7, 95% CI 1.3-105.1) was a predictor of high-risk moderate to severe DHR (score ≥2.5). Our predictive tool for perioperative DHR provided a modest predictive ability. History of drug allergies, rhinitis, morphine use and endotracheal intubation were significant risk factors of DHR after adjusting for age and type of surgery.

PLoS One published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Jin, Yuan published the artcileInfluence of parecoxib sodium infusion on postoperative agitation, stress reaction and vital signs of patients with laparoscopic surgery under combined anesthesia of propofol and remifentanil, Computed Properties of 198470-85-8, the publication is Zhongguo Xiandai Yixue Zazhi (2015), 25(8), 55-58, database is CAplus.

The purpose of the research is to investigate the influence of parecoxib sodium infusion before anesthesia induction on postoperative agitation, stress reaction and vital signs of the patients with laparoscopic surgery under combined anesthesia of propofol and remifentanil. A total of 120 cases of patients with laparoscopic surgery and general anesthesia in the Department of Gynaecol. were chosen and randomly divided into two groups including control group(60 cases of patients) with saline infusion and parecoxib sodium group(60 cases of patients) with parecoxib sodium infusion before anesthesia induction. The postoperative agitation grading, chills Wrench grading of and levels of vital sign indexes at different time points of both groups were compared. The postoperative agitation grading, chills Wrench grading of the parecoxib sodium group were significant better than those in the control group(P<0.05). The levels of E, NE and Cor at time points of extubation in the parecoxib sodium group were significant lower than those in the control group(P<0.05). The levels of vital sign indexes in the parecoxib sodium group were significantly lower than those in the control group at the time points of T₀, T₁, T₂ and T₃(P<0.05). There were no significant differences in the levels of vital sign indexes between both groups at the time point of T4(P>0.05). Parecoxib sodium infusion on patients with laparoscopic surgery under combined anesthesia of propofol and remifentanil can efficiently relieve postoperative agitation, reduce the level of stress response and maintain stable vital signs.

Zhongguo Xiandai Yixue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Computed Properties of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Gu, Xiaoxia published the artcileThe clinical effect of dexmedetomidine combined with parecoxib sodium on sedation, antianxiety and prevention of intubation stress in patients undergoing functional endoscopic sinus surgery: a randomised controlled trial, Related Products of isoxazole, the publication is BMC Anesthesiology (2020), 20(1), 166, database is CAplus and MEDLINE.

One hundred twenty patients undergoing endoscopic sinus surgery were randomly divided into four groups: group DP, group D, group P and group N. Ramsay sedation score in group D,DP was significantly higher than that in group P and group N, BIS, BP, HR and anxiety scores were significantly lower than those in the group P and group N. There was no significant difference in Ramsay sedation score, BIS value, anxiety score and BP, HR between group D and group DP. Compared with T4, there was no significant difference in BIS and BP, HR in group D, group DP and group P, but BIS, BP and HR in group N were significantly higher than T4. Three minutes after intubation there was no statistical difference in changes of Cor, E, NE and BS values compared with before intubation in group P and group DP (p > 0.05), but the changes of Cor, E, NE and BS values were significantly lower than that in group N. Compared with T0, values of NE, E, Cor, BS decreased in group D, DP and P at T4, group DP decreased more significantly than group D, while NE, E, Cor, BS of T6 are at same level as the base value. In group N, NE, E, Cor, BS of T4 were at the same level of T0, but significantly higher at T6. And at T6, NE and E in group D, P and N were significantly different from those in group DP.

BMC Anesthesiology published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wang, Ka published the artcileEffect of parecoxib sodium on intravenous anesthesia with propofol-fentanyl of gynecological laparoscopic surgery, Application In Synthesis of 198470-85-8, the publication is Xiandai Shengwuyixue Jinzhan (2014), 14(16), 3142-3144, 3166, database is CAplus.

The effect of parecoxib on i.v. anesthesia with propofol-fentanyl of patients undergoing gynecol. laparoscopic surgery was evaluated. Sixty patients (ASA I or II, 21053 years old, 41-72 kg) who were undergoing gynecol. laparoscopic surgery were selected and randomly divided into two groups: parecoxib group (group P) who were received i.v. parecoxib sodium and group NS who were received normal 0 mL before anesthesia induction for 15 min, 30 cases of each group. The same anesthetic induction method was used in the two groups. Bispectral index (BIS) was used as the index of depth of anesthesia, by which the target plasma concentration of propofol was adjusted to maintain the anesthesia. HR, MAP were recorded, recovery time, extubation time, the incidence of postoperative adverse reactions and VRS after extubation for five min were recorded. Compared with group NS, MAP at T3 to T6, HR at T3 to T5 in group P were lower, and there were statistically significant difference between two groups (P<0.05). The recovery time and extubation time showed no differences between group P and group NS. The incidence of agitation and the VRS score were decreased in group P, and there were statistically significant difference between two groups (P<0.05). Preemptive analgesia with parecoxib sodium can decrease the changes in hemodynamics, incidence of agitation and the VRS score from i.v. anesthesia with propofol-fentanyl in patients who were undergoing gynecol. laparoscopic surgery.

Xiandai Shengwuyixue Jinzhan published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C16H14O6, Application In Synthesis of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Lobov, G. I. published the artcileProtective Effect of Dexamethasone on Lipopolysaccharide-Induced Inhibition of Contractile Function of Isolated Lymphatic Vessels and Nodes, Safety of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Bulletin of Experimental Biology and Medicine (2018), 165(5), 602-605, database is CAplus and MEDLINE.

LPS has an inhibitory effect on contractile activity of bovine mesenteric lymphatic vessels and nodes and causes a pronounced decrease in the tone and phase contractions. The selective inhibitor of inducible NO synthase, 1400W, and cyclooxygenase-2 selective inhibitor, dynastat, significantly attenuated the inhibitory effect of LPS. Dexamethasone interferes with the inhibitory effect of LPS on bovine lymphatic vessels and nodes. It was concluded that LPS stimulates expression of inducible NO synthase and cyclooxygenase-2 in endothelial and smooth muscle cells of lymphatic vessels and nodes. Dexamethasone has a pronounced protective effect on the contractile function of lymphatic vessels and nodes affected by LPS and suppresses the expression of inducible NO synthase and cyclooxygenase-2.

Bulletin of Experimental Biology and Medicine published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Safety of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Sibi, Mukund P. published the artcileEnantioselective intermolecular free radical conjugate additions. Application of a pyrazole template, SDS of cas: 182122-10-7, the publication is Tetrahedron Letters (1997), 38(34), 5955-5958, database is CAplus.

An achiral pyrazole template has been evaluated in enantioselective conjugate radical additions The enantioselectivity using the pyrazole template is inferior to those obtained from an oxazolidinone template. The two templates give products of opposite configuration using the same chiral Lewis acid.

Tetrahedron Letters published new progress about 182122-10-7. 182122-10-7 belongs to isoxazole, auxiliary class BOX or PyBox,BOX or PyBox, name is (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), and the molecular formula is C8H17Br, SDS of cas: 182122-10-7.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem