Tag: M.W=350-400

Yao, Shao-hong published the artcileEffect of parecoxib sodium in remifentanil anesthesia during hip replacement surgery on cognitive function of elderly patients, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Xiandai Zhenduan Yu Zhiliao (2017), 28(8), 1423-1424, database is CAplus.

To explore the effect of parecoxib sodium in remifentanil anesthesia in hip replacement surgery on the cognitive function of elderly patients. We randomly selected 100 patients who received hip replacement surgery in our hospital as the research objects, and divided them into the control group and the observation group. After remifentanil anesthesia, they were given 0.9% sodium chloride solution and parecoxib sodium to compare and analyze application effects. The MMSE scores of patients in the observation group were significantly higher than those in the control group on the 1st and 7th day after surgery (P < 0.05). The Barthel index score and Harris score (89.23 ± 12.06) and (88.96 ± 12.76) points of the observation group were significantly higher than those of the control group (42.74 ± 11.46) and (45.57 ± 11.65) points (P < 0.05). The application of parecoxib sodium in remifentanil anesthesia in hip replacement surgery has a significant impact on the cognitive function of elderly patients, improves their postoperative cognitive function, has a good prognosis, is safe and reliable, and is of great significance.

Xiandai Zhenduan Yu Zhiliao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C4H5NS2, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Rong-sheng published the artcileComparison on efficacy of different doses of butorphanol combined with preoperative parecoxib sodium for postoperative patient-controlled intravenous analgesia in female patients, COA of Formula: C19H17N2NaO4S, the publication is Guangdong Yixue (2015), 36(4), 605-607, database is CAplus.

Objective: To explore the appropriate dose of butorphanol combined with preoperative parecoxib sodium for postoperative patient-controlled i.v. analgesia. Methods: 75 Cases of ASA I-II female patients undergoing lower abdomen or lower limb operation were selected. All patients underwent operation under spinal-epidural combined anesthesia. After operation, the patients were given butorphanol 6 mg (group A, n = 25), 8 mg (group B, n = 25) and 10 mg (group C, n = 25), resp. for patient-controlled i.v. analgesia. The above-mentioned butorphanol was diluted as 100 mL with physiol. saline solution The amount of background infusion was 1.8 mL/h, and the single dose was 2 mL. The patients were i.m. injected with tramadol 100 mg for rescue analgesia. Before incision, all patients were given parecoxib sodium 40 mg. After operation, the pain visual analog score (VAS score) and Ramsay sedation score (RSS score) were observed The adverse reactions and satisfaction of patients were recorded. Results: 6, 12 and 24 h after operation, the VAS score in group B and group C was significantly lower than that in group A (P < 0.05, P < 0.01). 48 H after operation, the usage amount of butorphanol in group A, group B and group C was successively increased (P < 0.01). The incidence (24%) of dizziness in group C was higher than that (4%) in group A. The proportion (24%) of rescue analgesia in group A was higher than that (4%) in the other two groups (P < 0.05). The VAS score and RSS score in three groups had no statistically significant difference (P > 0.05). Conclusion: For the female patients undergoing lower abdomen or lower limb operation, preoperative i.v. injection of parecoxib sodium 40 mg combined with postoperative 1.8 mL/h butorphanol 8 mg is suitable for patient-controlled i.v. analgesia.

Guangdong Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, COA of Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Dan published the artcileComparison of parecoxib sodium and flurbiprofen axetil in children undergoing endoscopic adenoidectomy and tonsillectomy, Computed Properties of 198470-85-8, the publication is Guoji Mazuixue Yu Fusu Zazhi (2014), 35(12), 1098-1100, 1108, database is CAplus.

The postoperative analgesia effect of parecoxib Na and flurbiprofen axetil in children undergoing endoscopic adenoidectomy and tonsillectomy was comparatively studied. Sixty children, aged 5-8 yr, scheduled for endoscopic adenoidectomy and tonsillectomy under general anesthesia were randomly divided into group A (parecoxib Na), group B(flurbiprofen axetil), group C (normal saline) (n=20). Parecoxib Na 1 mg/kg and flurbiprofen axetil 1 mg/kg were administered i.v. 15 min before the start of operation, meanwhile children in group C received normal saline. The extubation time, agitation occurrences, recovery period pain scores, remifentanil dose, and side effects were observed and compared. There was no difference between the three groups in operation time, extubation time, and remifentanil dose (P>0.05). The emergence of postoperative agitation was 5% in group A and group B, 55% in group C, which was significantly lower in group A and group B than in group C (P<0.01). The pain scores of group C were significantly higher than those in group A and group B (P<0.01). The emergence of nausea and vomiting was 5% in group C. Applying parecoxib Na and flurbiprofen axetil in children undergoing endoscopic adenoidectomy and tonsillectomy can provide a good analgesia effect, reduce postoperative agitation, and do not postpone the extubation time.

Guoji Mazuixue Yu Fusu Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Computed Properties of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wang, Bo published the artcileMechanisms and progress of parecoxib sodium, Product Details of C19H17N2NaO4S, the publication is Hainan Yixue (2014), 25(23), 3496-3499, database is CAplus.

A review. Parecoxib sodium, a novel COX-2 specific inhibitor, is now widely used in clin. prevention and treatment of moderate to severe pain. Recent studies have suggested that parecoxib sodium exerts not only an analgesic effect but also some non-analgesic effects. Parecoxib sodium reduces cerebral ischemic neuronal damage, protects or deteriorates ischemic organs, produces anti-tumor effects, as well as against angiogenesis effect. The study on the non-analgesic effects of parecoxib sodium provides theor. basis for expanding its clin. applications. In this paper, we reviewed the progress in the functional roles of parecoxib sodium and its underlying mechanisms.

Hainan Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C24H29N5O3, Product Details of C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Deng, Li-Qin published the artcileEffect of pre-emptive analgesia by continuous femoral nerve block on early postoperative cognitive function following total knee arthroplasty in elderly patients, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Experimental and Therapeutic Medicine (2017), 13(4), 1592-1597, database is CAplus and MEDLINE.

To the best of our knowledge, the effect of pre-emptively blocking pain transmission on acute postopera- tive cognitive dysfunction (POCD) has not yet been assessed. Therefore, the present study aimed to investigate the effect of pre-emptive analgesia via a continuous femoral nerve block (CFNB) on postoperative pain and early cognitive function following total knee arthroplasty (TKA) surgery in elderly patients. CFNB was performed prior to TKA surgery in the pre- emptive analgesia group (n=30) and following TKA surgery in the control group (n=30). POCD was defined as a two-point reduction in the postoperative score compared with the preop- erative score in the mini-mental state examination The visual analog scale (VAS) was used to evaluate the intensity of pain at rest and during exercise. The intraoperative dose of remi- fentanil in the pre-emptive analgesia group was significantly lower than in the control group (P<0.01). In the preemptive analgesia group, VAS scores at three days post-surgery were lower than those in the control group (P<0.01). The incidence of POCD on the third postoperative day was slightly lower in the pre-emptive analgesia group compared with the control group. In conclusion, the results demonstrate that pre-emptive analgesia by CFNB may promote the recovery of early cogni- tive function following TKA in elderly patients.

Experimental and Therapeutic Medicine published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhang, Chaofeng published the artcileParacoxib Alleviates Ventilator-Induced Lung Injury Through Functional Modulation of Lung-Recruited CD11bloLy6Chi Monocytes, Formula: C19H17N2NaO4S, the publication is Shock (2021), 55(2), 236-243, database is CAplus and MEDLINE.

Lung-recruited Ly6Chi monocytes had been shown to be involved in ventilator-induced lung injury (VILI). Our present study aimed to investigate whether the cyclooxygenase-2 (COX-2) inhibition modulates the function of lung-recruited Ly6Chi monocytes in a mouse model of VILI. Mice were exposed to lipopolysaccharide (LPS; 20 ng) i.p. prior to injurious mech. ventilation (Vt=30mL/kg, PEEP=0cmH2O). A subgroup of mice was treated with i.v. parecoxib (30mg/kg), a COX-2 inhibitor, 1 h prior to ventilation. Control mice received saline and were not ventilated. At the end of the experiment, blood gas anal. was performed and lung tissue was collected for histol. assessment. Flow cytometry was employed to quantify the different populations of lung monocytes/macrophages and their function. Isolated Ly6Chi cells were used to measure the intracellular concentrations of reactive oxygen species (ROS) and nitric oxide (NO) by fluorescent probes, and cytokine production by cytometric bead array. Exposure to LPS and injurious ventilation was associated with severe lung histol. damage, oxygenation impairment, and pulmonary edema; all of which were largely attenuated following the treatment of parecoxib. Furthermore, flow cytometry anal. revealed that parecoxib caused a reduction in the number of the lung-recruited CD11bloLy6Chi monocytes while there was no effect on tissue-resident CD64+ alveolar macrophages. In addition, the production of oxidative stress products (ROS, NO), MHC-II expression, and inflammatory cytokines in response to LPS and VILI in CD11bloLy6Chi monocytes was ameliorated by parecoxib. Parecoxib-induced alleviation of oxidative stress and inflammation in lung-recruited Ly6Chi monocytes may partly explain the beneficial action of COX-2 inhibition in VILI.

Shock published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C7H6Cl2, Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Li-biao published the artcileComparison of pain thresholds and analgesic effects of parecoxib sodium in surgical patients of different racial and religious backgrounds, Synthetic Route of 198470-85-8, the publication is Zhongguo Yixue Kexueyuan Xuebao (2015), 37(3), 325-330, database is CAplus and MEDLINE.

The aim is to explore the differences of pain thresholds and analgesic effects of parecoxib sodium among patients with different racial and religious backgrounds. A total of 48 male patients aged 18 to 38 years who had undergone elective laparoscopic appendectomy under general anesthesia in our center were enrolled in our study, and then divided into 6 groups(n=8 in each group) based on their racial backgrounds(three levels: Mongoloid, Negroid, and Europoid) and religious backgrounds(two levels: without religion background, with religion background). All subjects received same anesthesia, surgical procedure, and postoperative analgesia with parecoxib sodium. The temperature pain threshold and elec. pain threshold were detected 1 h before and after analgesia. The threshold of pain was higher in Europoids than that in Negroids and Mongoloids before and after treatment. The temperature pain threshold and elec. pain threshold were not significantly different between subjects with or without religious background(before analgesic therapy: F=251.119, P=0.130, F=275.861, P=0.059; after analgesic therapy: F=308.531, P=0.086, F=180.062, P=0.078). Also, there was no interaction between the racial and religious backgrounds in terms of temperature pain threshold and elec. pain threshold(F=13.553, P=0.091, F=22.001, P=0.089; after analgesic therapy: F=4.624, P=0.089, F=15.935, P=0.094). The threshold of pain differed among individuals with different racial background, and it was the highest in Europoids, followed by Negroids and Mongoloids. It showed no obvious difference in people with different religious backgrounds.

Zhongguo Yixue Kexueyuan Xuebao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Synthetic Route of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Long, Hao published the artcileSafety and efficacy of parecoxib sodium in multimode analgesia after osteoarticular surgery, HPLC of Formula: 198470-85-8, the publication is Zhongguo Jiaoxing Waike Zazhi (2014), 22(5), 458-460, database is CAplus.

Objective: To evaluate the safety and efficacy of parecoxib sodium in multimode analgesia after osteoarticular surgery. Methods: 90 patients were divided into group A (parecoxib sodium combined with fentanyl PCIA) and group B (fentanyl PCIA). Group A is further divided into group A 1: venous group (40 mg/time, 1 time/12 h i.v. infusion) and A 2 group: s.c. injection group (40 mg/ time 1 time /12 h). The VAS score, fentanyl dosage and ADR, PCA press number and effective number of each group at 48 h postoperatively were compared. Results: Group A and group B had statistically significant difference in VAS score, fentanyl dosage and ADR, PCA press number and effective (P < 0.05 ). In group A, the venous group and s.c. injection group had no statistically significant difference (P>0.05). Conclusion: The parecoxib sodium combined with PCA multimode analgesia can reduce fentanyl dose and alleviate pain at 48 h postoperatively.

Zhongguo Jiaoxing Waike Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, HPLC of Formula: 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Barnes, David M. published the artcileDevelopment of a catalytic, asymmetric Michael addition in the synthesis of endothelin antagonist ABT-546, Recommanded Product: (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), the publication is ACS Symposium Series (2002), 45-59, database is CAplus.

The selective endothelin A antagonist ABT-546 I is prepared enantioselectively on large (13 mol) scale using the catalytic addition of ketoester II to nitrostyrene III in the presence of bisoxazoline IV and magnesium triflate as the key step. E.g., magnesium triflate is hydrated in chloroform; ligand IV is added and the mixture stirred for about 1 h to generate the active catalyst. E.g., II and III are added with mol. sieves to give a 0.2 M solution; N-methylmorpholine is added as an amine cocatalyst when the mixture is dry and the reaction is stirred to give intermediate V in 83% yield and 88% ee on 13 mol scale. The Michael addition reaction was extensively optimized. No other bisoxazoline ligand tested was as effective as IV. Other magnesium salts with coordinating anions are less effective as catalysts. An amine cocatalyst is necessary for high stereoselectivity in the Michael addition Chloroform is the best solvent for the Michael addition, although toluene also is effective. The presence of water during the generation of the active catalyst is necessary for high yields, but the presence of water during the reaction inhibits the reaction and decreases selectivity; the use of mol. sieves is necessary to obtain product in high yields. The purity of the substrates in the enantioselective Michael addition is important for good rates and selectivities. The scope of the asym. Michael addition reaction of ketoesters to nitroolefins to give nitroketoesters is extended to other ketoester and malonate nucleophiles such as di-Et malonate, and to other nitroolefins such as β-nitrostyrene and 1-nitro-1-heptene.

ACS Symposium Series published new progress about 182122-10-7. 182122-10-7 belongs to isoxazole, auxiliary class BOX or PyBox,BOX or PyBox, name is (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), and the molecular formula is C24H22N2O2, Recommanded Product: (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole).

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Sibi, Mukund P. published the artcilePractical and Efficient Enantioselective Conjugate Radical Additions, Name: (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), the publication is Journal of Organic Chemistry (1997), 62(12), 3800-3801, database is CAplus.

Outstanding levels of enantioselectivity (up to 97% ee) using catalytic amounts of chiral Lewis acids in conjugate radical additions was achieved. Addnl., high levels of enantioselectivity at room temperature using sub-stoichiometric amounts of chiral Lewis acid are also reported. Thus, iso-Pr radical addition to N-cinnamoyl oxazolidinone at -78° using a chiral Lewis acid derived from MgI₂ and chiral bioxazoline (4S,5R)-I in sub-stoichiometric yield (40 mol %) provides conjugate addition product (R)-II of high optical purity (94% isolated yield, 97% ee). The effects of bite angle and dihedral angle in a variety of chiral bioxazoline ligands on the enantioselectivity and absolute stereochem. of the conjugate radical addition reaction were studied.

Journal of Organic Chemistry published new progress about 182122-10-7. 182122-10-7 belongs to isoxazole, auxiliary class BOX or PyBox,BOX or PyBox, name is (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), and the molecular formula is C15H10O2, Name: (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole).

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem