Tag: M.W=350-400

Luo, Pengfei published the artcileEffects of parecoxib sodium on cognitive function of elderly patients after hepatectomy for liver cancer, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Zhongguo Putong Waike Zazhi (2014), 23(7), 887-892, database is CAplus.

The effects of using parecoxib sodium for analgesia on post-hepatectomy cognitive function in elderly patients were investigated. Eighty patients over 60 years of age undergoing elective hepatectomy for liver cancer were randomly assigned into observational group and control group, with 40 cases in each group. Patients in observational group received parecoxib sodium administration after surgery (40 mg, i.v. injection, and once per 12 h for 3 d), and those in control group were given normal saline as placebo. And addnl. tramadol was used in either group according to need for analgesia to maintain the pain visual analog scale (VAS) not more than a score of 3. The Wechsler Adult Intelligence Scale (WAIS) and Wechsler Memory Scale (WMS) were used to test the incidence of postoperative cognitive dysfunction (POCD) in both groups of patients, and the blood levels of S-100β protein, inflammatory cytokines, cortisol, and ammonia were detected before surgery and on several time points after surgery. The perioperative data between the two groups of patients showed no statistical difference. The incidence of POCD was significantly lower in observational group than that in control group (7.5% vs. 2.5%, P<0.05). The levels of cortisol, interleukin-4 (IL-4) and ammonia had no significant alteration in both group at any postoperative time points compared with their preoperative levels. The levels of S-100β protein, IL-6, tumor necrosis factor-α (TNF-α), IL-1β and C-reactive protein (CRP) in both groups were significantly increased in different time spans with varying degrees in both groups compared with their preoperative levels, but the increasing degrees of S-100β protein and IL-6 in observational group were less than those in control group within postoperative 24 and 48 h, resp. Parecoxib sodium administration could help improve the post-hepatectomy cognitive function in elderly patients, and the mechanism might probably associated with its decreasing the S-100β and IL-6 levels.

Zhongguo Putong Waike Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wang, Yu published the artcileAnalgesic effect of parecoxib sodium and tramadol in painless induced abortion, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Sichuan Yixue (2015), 36(1), 100-102, database is CAplus.

Objective: To compare the effect of parecoxib sodium and tramadol in combination with propofol on postoperative analgesia in painless induced abortion. Methods: 120 Cases of pregnant women of ASA I-II grade undergoing painless induced abortion were randomly divided into three groups. P group was preoperatively injected with 40 mg of parecoxib sodium, Q group was preoperatively injected with 100 mg of tramadol, and X group was preoperatively injected with 40 mg of parecoxib sodium and 100 mg of tramadol, and all groups were treated with 1.5-2.5 mg/kg propofol for anesthesia. The intraoperative consumption of propofol, intraoperative and postoperative analgesic effect and adverse reactions in the three groups were compared. Results: The intraoperative consumption of propofol in X group was significantly lower than that in P group and Q group (P < 0.05). All groups have good intraoperative analgesic effect without statistically significant difference (P > 0.05). The uterine contraction pain VAS scores at each time point during surgery in X group were significantly lower than those in P group and Q group, with statistically significant differences (P < 0.05). The difference of incidence of nausea and vomiting between the three groups was not statistically significant (P > 0.05). Conclusion: Application of parecoxib sodium combined with tramadol in painless induced abortion can reduce the intraoperative consumption of propofol, and has better efficacy than simple parecoxib sodium or tramadol.

Sichuan Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H14O2, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Song, Jie published the artcileEffect of parecoxib sodium on inflammatory mediator and postoperative cognitive dysfunction after laparoscopic surgery in elderly patients, Synthetic Route of 198470-85-8, the publication is Guoji Mazuixue Yu Fusu Zazhi (2015), 36(6), 493-495, 501, database is CAplus.

The effects of parecoxib Na on inflammatory mediator and postoperative cognitive dysfunction (POCD) after laparoscopy surgery in elderly patients were studied. Eighty ASA patients phys. status I or II of both sexes, aged over 65 yr, weighing 45-70 kg, undergoing laparoscopic cholecystectomy, were randomly divided into parecoxib Na (group P, n=40) and control groups (group C, n=40). The patients in group P were given i.v. parecoxib 40 mg before induction of anesthesia. Ones in group C were given equal volume normal saline instead of parecoxib. Neuropsychol. testing was performed with mini-mental state examination (MMSE) on the preoperative day, 1st and 3rd postoperative day. Venous blood samples were collected before induction of anesthesia (T₀), immediately after skin incision (T₁), 30 min after CO₂ pneumoperitoneum (T₂), at the end of operation (T₃), the first day of operation (T₄), the third day of operation(T₅) for determination of serum concentrations of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) by enzyme linked immunosorbent assay (ELISA). The development of POCD was recorded within 3 days after surgery. Compared with preoperative 24 h [group C (28.2±1.2), group P (28.8±1.0)], the MMSE scores of resting in group C and group P were significantly reduced [(23.0±2.5), (25.0±2.8)] (P<0.05). The MMSE scores of resting in group P were more than those in group C [(25.0±2.8) vs (23.0±2.5)] (P<0.05). The development of POCD within 72 h was less than that in group C (P<0.05). Compared with group C, the serum concentrations of TNFa [(11.8±1.7), (13.8±1.3), (12.3±1.6) ng/L] and IL-6 [(11.8±1.7), (13.8±1.3), (12.3±1.6) ng/L] at T₃-T₅ were significantly decreased in group P (P<0.05). Compared with T₀, the serum concentrations of TNF-α and IL-6 at T₃-T₅ were increased in two group (P<0.05). Parecoxib Na might decrease the development of POCD in elderly patients undergoing laparoscopic cholecystectomy by inhibition of inflammatory responses.

Guoji Mazuixue Yu Fusu Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C7H6O3, Synthetic Route of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Sun, Xiu-rong published the artcileObservation on analgesic effect of parecoxib sodium on patients undergoing subtotal thyroidectomy, Formula: C19H17N2NaO4S, the publication is Shiyong Yaowu Yu Linchuang (2016), 19(5), 599-601, database is CAplus.

To discuss the analgesic effect of parecoxib sodium on patients who have undergone subtotal thyroidectomy. The clin. data of 105 cases who had undergone subtotal thyroidectomy in our hospital from Nov. 2014 to Nov. 2015 were collected. The patients were given i.v. injection of parecoxib sodium (40 mg) 15 min before the end of operation (group A). The patients were given i.v. injection of parecoxib sodium (40 mg) immediately after patients returned to the wards (B group). The patients were given i.v. injection of NS (2 mL) solution 15 min before the end of operation (group C). Each group included 35 cases. The visual simulation pain score (VAS score) at 0, 2, 4, 6, 12, and 24 h after returning to the ward, postoperative analgesia satisfaction rate 1 d after operation and the incidence of side effects of the three groups were observed and compared. The VAS scores of A and B groups at each time point were significantly lower than that of C group, with statistically significant difference (P < 0.05). The VAS scores of A group (0, 2 h) were lower than those of B group, with statistically significant difference (P < 0.05). The postoperative occurrence rate of side effects of the three groups had no statistical significance (P > 0.05). Application of parecoxib during or after thyroid subtotal surgery can reduce postoperative pain and increase satisfaction of analgesic effect. Moreover, application of parecoxib is safe and reliable. Giving i.v. injection of parecoxib sodium 15 min before the end of surgery is a better choice.

Shiyong Yaowu Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C7H5ClN2S, Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Hallen, K. published the artcileIsocapnic hyperventilation provides early extubation after head and neck surgery: A prospective randomized trial, Application In Synthesis of 198470-85-8, the publication is Acta Anaesthesiologica Scandinavica (2018), 62(8), 1064-1071, database is CAplus and MEDLINE.

Background : Isocapnic hyperventilation (IHV) shortens recovery time after inhalation anesthesia by increasing ventilation while maintaining a normal airway carbon dioxide (CO2)-level. One way of performing IHV is to infuse CO2 to the inspiratory limb of a breathing circuit during mech. hyperventilation (HV). In a prospective randomized study, we compared this IHV technique to a standard emergence procedure (control). Methods : Thirty-one adult ASA I-III patients undergoing long-duration (>3 h) sevoflurane anesthesia for major head and neck surgery were included and randomized to IHV-treatment (n = 16) or control (n = 15). IHV was performed at minute ventilation 13.6 ± 4.3 L/min and CO2 delivery, dosed according to a nomogram tested in a pilot study. Time to extubation and eye-opening was recorded. Inspired (FICO2) and expired (FETCO2) CO2 and arterial CO2 levels (PaCO2) were monitored. Cognition was tested preoperatively and at 20, 40 and 60 min after surgery. Results : Time from turning off the vaporizer to extubation was 13.7 ± 2.5 min in the IHV group and 27.4 ± 6.5 min in controls (P < .001). Two minutes after extubation, PaCO2 was 6.2 ± 0.5 and 6.2 ± 0.6 kPa in the IHV and control group resp. In 69% (IHV) vs 53% (controls), post-operative cognition returned to pre-operative values within 40 min after surgery (NS). Incidences of pain and nausea/vomiting did not differ between groups. Conclusions : In this randomized trial comparing an IHV method with a standard weaning procedure, time to extubation was reduced with 50% in the IHV group. The described IHV method can be used to decrease emergence time from inhalation anesthesia.

Acta Anaesthesiologica Scandinavica published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Application In Synthesis of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Tang, Ni published the artcileEffect of paricoxib sodium on postoperative cognitive function in elderly depression rats, Product Details of C19H17N2NaO4S, the publication is Yiyao Daobao (2016), 35(1), 12-15, database is CAplus.

Objective To investigate the effect of paricoxib sodium on postoperative cognitive dysfunction (POCD) in elderly depression rats. Methods The total of 36 elderly male Sprague Dawley (SD) rats were divided into 3 groups: normal control group (n = 6); surgical group (Sur group, n = 15); paricoxib sodium group (Pare group, n = 15). Depression models were established in rats except those in the normal control group. The 5 mg·kg^-1 paricoxib sodium was i. p. injected in the Pare group 1 h prior to, 8 h, 2 d and 3 d post operation, resp. And 0.9% sodium chloride injection was i. p. injected into the Sur group. Behavior and cognition of all animals were evaluated by open-field, sucrose consumption and Morris water maze tests. IL-6 and IL-1β expression were detected by Elisa. Results The escape latency was (39.98±8.93) s in Pare group vs (47.15±10.87) s in Sur group (P<0.05); and the space exploration was (24.17±8.52) s vs (20.96±9.58) s (P<0.05). IL-6 expression was (72.86±6.82) in Pare group vs (79.26±4.19) ng·L^-1 in Sur group, IL-1β expression was (350.73±28.04) vs (423.35±26.81) ng·L^-1 (P<0.05). The horizontal and vertical scores were significantly higher in Pare group than those in the Sur group (P<0.05). The sucrose consumption and sucrose preference were higher and the water consumption was lower in Pare group than those in the Sur group (P<0.05). Conclusion Parecoxib sodium may improve postoperative cognition of elderly rats with depression, which being associated with decrease of IL-6 and IL-1β expression in hippocampus.

Yiyao Daobao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C5H8N2O, Product Details of C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Sun, Li-ping published the artcileApplication of advanced analgesia in early rehabilitation after knee replacement, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Zhongguo Jiaoxing Waike Zazhi (2016), 24(21), 2004-2006, database is CAplus.

[Objective]: The article observed the clin. efficacy of advanced anti-inflammatory analgesia in early functional rehabilitation after knee replacement. [Methods]: The article randomly divided 60 patients with unilateral knee arthroplasty who were admitted to our hospital from June 2013 to Jan. 2015 into two groups, 30 in each group, and celecoxib in the advanced analgesia group combined with parecoxib sodium for advanced analgesia, the analgesia pump group used postoperative i.v. analgesia pump. The article recorded the VAS scores of patients at rest at 6, 12, 24, 48, and 72 h postoperatively, the knee joint mobility, and the number of adverse reactions at 1, 2, 3, 7, and 14 days after surgery for statistical anal. [Result]: The postoperative analgesia effect of the advanced analgesia group was significantly better than that of the analgesia pump group (P < 0.05), the range of knee movement was significantly greater than that of the analgesia pump group (P < 0.05), and the number of adverse reactions was significantly less In the analgesic pump group (P < 0.05). [Conclusion]: Advanced anti-inflammatory analgesia could obviously eliminate the pain after knee replacement, and early rehabilitation of knee function could be performed.

Zhongguo Jiaoxing Waike Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C27H39ClN2, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Davies, Ian W. published the artcileThe influence of ligand bite angle on the enantioselectivity of copper(II)-catalyzed Diels-Alder reactions, Category: isoxazole, the publication is Chemical Communications (Cambridge) (1996), 1753-1754, database is CAplus.

Novel spirobis(oxazoline) complexes, formed from I (n = 1-4), provide excellent levels of stereocontrol in copper-catalyzed Diels-Alder reactions; the larger the ligand bite angle, the higher the enantioselection (up to 98.4% ee).

Chemical Communications (Cambridge) published new progress about 182122-10-7. 182122-10-7 belongs to isoxazole, auxiliary class BOX or PyBox,BOX or PyBox, name is (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), and the molecular formula is C24H22N2O2, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhou, Xiao-dao published the artcileInfluence of parecoxib Na on anesthesia recovery period of patients under the fast track anesthesia with remifentanil, Product Details of C19H17N2NaO4S, the publication is Zhongguo Linchuang Yaolixue Zazhi (2015), 31(9), 708-711, database is CAplus.

Objective To investigate the effects of preoperative use of parecoxib Na during anesthesia recovery period on the fast track anesthesia with remifentanil. Methods A total of 105 cases who received laparoscopic cholecystectomy were randomly divided into three groups with 35 cases in each group. Patients in group A received parecoxib Na 40 mg dissolved in normal saline 10 mL through injection 20 min before induction of anesthesia. Patients in group B received parecoxib Na 40 mg dissolved in normal saline10 mL through injection 20 min before the end of surgery. Patients in group C received normal saline 10 mL through injection 20 min before induction of anesthesia. The data of mean arterial pressure (MAP), heart rate (HR) and oxygen saturation (SPO₂), verbal rating scale (VRS), sedation-agitation scale (SAS), Ramsay sedation scale (RSS) and comfort score (BCS) were compared among three groups. Results The data of MAP, SAS and HR in group A and group B were significantly lower than those in group C, and the data of MAP, SAS and HR in group A were significantly lower than those in group B (P<0.05). The data of RSS in group A was significantly lower than that in group B and RSS in group A and group B significantly higher than those in group C from T₂ to T₄ (P<0.05). The data of VRS in group A and group B were significantly lower than those in group C, and that in group A was significantly lower than group B each time point (P<0.05). Postoperative BCS in group A and group B were significantly higher than those in group C, and that in group A was significantly higher than group B (P<0.05). Conclusion Preoperative use of parecoxib Na could significantly reduce the acute pain of the fast track anesthesia with remifentanil, effectively inhibiting hyperalgesia and reducing the patient’s agitation.

Zhongguo Linchuang Yaolixue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C12H9N3O4, Product Details of C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yu, Chengxuan published the artcileClinical characteristics of hospitalized patients with drug-induced acute kidney injury and associated risk factors: a case-control study, Category: isoxazole, the publication is BioMed Research International (2020), 9742754, database is CAplus and MEDLINE.

Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clin. characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. A retrospective study among hospitalized patients was conducted in July 2019 based on the Adverse Drug Events Active Surveillance and Assessment System-2 developed by the authors. Four controls were matched with each case according to the matching criteria. The risk factors for D-AKI were identified by binary multivariate logistic regression. A total of 23,073 patients were hospitalized in July 2019, 21,131 of whom satisfied the inclusion criteria. The independent risk factors for D-AKI consisted of alc. abuse (odds ratio (OR), 2.05; 95% confidence interval (CI), 1.04-4.07), nonsteroidal anti-inflammatory drug (NSAID) use (OR, 2.39; 95% CI, 1.25-4.58), diuretic use (OR, 2.64; 95% CI, 1.42-4.92), prior anemia (OR, 4.10; 95% CI, 1.94-8.67), and prior chronic kidney disease (OR, 2.33; 95% CI, 1.07-5.08). The occurrence of D-AKI in hospitalized patients had significant associations with alc. abuse, combination therapy with NSAIDs or diuretics, and prior anemia or chronic kidney disease. Clinicians should meticulously follow patients with the above characteristics.

BioMed Research International published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C4H6O3, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem