Month: October 2020

21169-71-1, Isoxazole-5-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of isoxazole-5-carboxylic acid (2.5 g 22.1 mmol), sodium bicarbonate (5.57 g, 66.32 mmol) and iodomethane (8.26 mL, 132.65 mmol) in DMF (30 mL) was stirred at 25 C. over 19 h. The mixture was diluted in H2O (30 mL) and extracted with ether (2¡Á50 mL). The ether layer washed with brine, dried over MgSO4, filtered, concentrated in vacuo to obtain a crude oil. The crude was further purified by Biotage chromatography (cartridge 40m), eluent EtOAc-Hexanes (1:2), then 100% EtOAc to obtain isoxazole-5-carboxylic acid methyl ester as an amorphous solid (1.2 g, 42.7%). Mass Spectrum (+ESI): 128 (M+H)+., 21169-71-1

The synthetic route of 21169-71-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth; US2007/219186; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

123770-62-7, Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (50.0 mg, 0.29 mmol) in DCM (2 mL) was added diethylaminosulfur trifluoride (70.6 mg, 0.06 ml, 0.44 mmol). The mixture was stirred at 40 C for 1 hour. Water (3 mL) was added and the mixture was extracted with ethyl acetate (5 mLchi3). The combined organic layers were washed with brine (5 mL), dried over Na2S04and concentrated. The crude mixture was purified by flash chromatography with heptane:ethyl acetate = 1 :0 to 0:1 to give ethyl 5- (fluoromethyl)isoxazole-3-carboxylate (41 .0 mg).

123770-62-7, The synthetic route of 123770-62-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (270 pag.)WO2018/7249; (2018); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108511-97-3,Isoxazol-4-amine,as a common compound, the synthetic route is as follows.

1-Chloro-4-iodo-2-trifluoromethylbenzene (10 mmol) obtained in Reaction 1.2 was dissolved in 20 ml of toluene.Isoxazole-4-amine (12 mmol) was added sequentially to the system.Palladium acetate (0.5 mmol),2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (12 mmol),3 ml of triethylamine,After stirring for 10 minutes,Add 10 ml of aqueous solution of cesium carbonate (10 mmol),Heat to 50 C for 4 hours.After the reaction was completed, 20 ml of water was added to the system, and the mixture was stirred for 20 minutes, and the organic phase was dried over anhydrous sodium sulfate, concentrated, and purified by flash column chromatography.2.2 g of yellow N-(4-chloro-3-trifluoromethylphenyl)-isoxazole-4-amine powder was obtained in a yield of 84%.

108511-97-3, The synthetic route of 108511-97-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhang Ruwei; Ge Baoyin; Jing Fan; (7 pag.)CN108440437; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1228690-37-6, (R)-1-Phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Argon was bubbled through the mixture of compound CIII-7 (200 mg, 0.6 mmol), compound CIII-8 (242 mg, 0.6 mmol) and Na2C03 (127 mg, 1.20 mmol) in a mixed solvent of DME/H20 (6 mL, v/v = 3/1). Then the catalyst Pd(dppf)Cl2 (22 mg, 0.03 mmol) was added. The mixture was heated to 80 C and stirred for 2 hours. The mixture was filtered through Celite and the filtrate was concentrated. The residue was purified by column chromatography over silica gel (PE/EA = 5/1) to yield compound CIII-9 (290 mg, yield 91 >). MS (ESI) m/z (M+H)+ 526.3., 1228690-37-6

The synthetic route of 1228690-37-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.; WO2013/25733; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.,62348-13-4

Compound 6 (11.8g, 28.06mmol) was added to absolute ethanol (150 mL), followed by gradual addition of isoxazole-5-carbonyl chloride (10.2g, 77.55mmol), The reaction was heated to reflux with stirring. After about 8 hours, the reaction was completed and TLC was used to monitor the end of the reaction.point. After the reaction solution was allowed to stand for cooling, suction filtration, and the filter cake was washed with a small amount of anhydrous ethanol to obtain a white solid product N-(((4-(2,3-dihydro-[1,4]dioxacyclohexane) Alkeno[2,3-b]pyridin-7-yl)-7-methoxy-2,2-dimethylpyridin-3-yl)methyl)sulfonyl)isoxazole-5-carboxamide, 13.8 g, yield 95.6%.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; Zeng Qingqiang; (11 pag.)CN108570056; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

59669-59-9, 3-(tert-Butyl)isoxazol-5-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,59669-59-9

General procedure: To a stirred solution of ynamide 4a (57.0 mg, 0.2 mmol) in DCE (2.0 mL, 0.1 M) was added isoxazol-5-amine 8a (21.6 mg, 0.22 mmol, 1.1 equiv), followed by AgNTf2 (3.9 mg, 5 mol %). The resulting mixture was placed into an oil bath of 80 C with stirring for 2 h generally, monitoredby TLC. After completion, the reaction mixture was cooled and the desired product was precipitated. The solid was filtered and washed with DCM twice, then dried in a vacuum drying oven at 50 C for 24 h to give the pure pyrrole product 10aa, 75.8 mg, 99% yield. For products 10ab-ae, 10ka-la, the purification method was as follows: evaporation of volatiles under reduced pressure to give the residue, which was suffered from column chromatographyon silica gel (petrol ether/ethyl acetate 1:1-1:2, v/v) to afford the pure pyrrole.

As the paragraph descriping shows that 59669-59-9 is playing an increasingly important role.

Reference£º
Article; Cao, Ziping; Zhu, Jiekun; Liu, Li; Pang, Yuanling; Tian, Laijin; Sun, Xuejun; Meng, Xin; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 2623 – 2630;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228690-37-6,(R)-1-Phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate,as a common compound, the synthetic route is as follows.

Step 6: l-{4′-[3-Methyl-4-((R)-l-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4- yl}-cyclopropanecarboxylic acid: [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid (R)- l- phenyl-ethyl ester (0.248g, 0.62mmol), 4-(l’-carboxyl-cyclopropyl)phenylboronic acid (0.160g, 0.62mmol), and sodium carbonate (0.155g, 1.85mmol) were combined in 2: 1 DME:H20. The solution was purged with N2 for 10 minutes, and then bis(triphenylphosphine)palladium(II) dichloride (0.047g, 0.06mmol) was added. The reaction was purged with N2 for an additional 10 minutes, and then stirred in a sealed tube at 80C for 2 hours. The mixture was partitioned between EtOAc and H20, and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over MgSO/t, filtered, and concentrated, and the residue was purified by silica gel chromatography to give the title compound. Mass spec, data (M+H) = 483.

1228690-37-6, The synthetic route of 1228690-37-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMIRA PHARMACEUTICALS, INC.; BRISTOL-MYERS SQUIBB COMPANY; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; HUTCHINSON, John, Howard; KING, Christopher, David; ROSSO, Victor, W.; WO2012/78805; (2012); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

INTERMEDIATE 6 – PREPARATION OF Ethyl 5-(bromomethyl)isoxazole-3-carboxylate.; Method 1 Carbon tetrabromide (5.44 g; 16.39 mmol) was added to the solution of triphenylphosphine (4.34 g, 16.39 mmol) in THF (50 mL) and the resulting mixture was stirred at room temperature for 15 min. To this green suspension was added a solution of ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (1.87 g, 10.93 mmol) in THF (10 mL) and the resulting reaction mixture was stirred overnight at room temperature. The solid material was removed by filtration. The filtrate was concentrated under reduced pressure and the residue was purified by flash chromatography on silica gel (eluent: 15 to 100% dichloromethane in heptane) to afford 1.73 g (68 %) of ethyl 5-(bromomethyl)isoxazole-3- carboxylate as a solid.

123770-62-7, 123770-62-7 Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 8027233, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick; WO2010/142801; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

2510-36-3, 3,5-Dimethylisoxasole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 6-(5-aminomethyl-pyridin-3-yl)-1-methyl-3,4-dihydro-1H-quinolin-2-one (example 36, 0.047 g, 0.177 mmol) in DMF (1 mL) were added 3,5-dimethylisoxazole-4-carboxylic acid (0.037 g, 0.266 mmol) and TBTU (0.063 g, 0.195 mmol) followed by Huenig’s base (0.048 g, 0.372 mmol) and the reaction mixture was stirred at room temperature over night. The mixture was purified directly by reverse phase HPLC on a Gemini-NX column, eluting with a 20 to 98% MeOH-H2O (0.05% TEA) gradient to give the title compound (0.041 g, 59%) as a colorless solid. MS: 391.3 (M+H+)

2510-36-3, As the paragraph descriping shows that 2510-36-3 is playing an increasingly important role.

Reference£º
Patent; Aebi, Johannes; Amrein, Kurt; Hornsperger, Benoit; Knust, Henner; Kuhn, Bernd; Liu, Yongfu; Maerki, Hans P.; Mayweg, Alexander V.; Mohr, Peter; Tan, Xuefei; Zhou, Mingwei; US2013/72679; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

42831-50-5, 5-Methylisoxazole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A 5-Methyl-isoxazole-4-carboxylic acid [2-(4-methoxy-phenylamino)-phenyl]-amide To N-(4-methoxy-phenyl)-benzene-1,2-diamine di-hydrochloride salt (0.942 g, 3.28 mmol), 5-methyl-isoxazole-4-carboxylic acid (0.500 g, 3.93 mmol), Et3N (4.6 ml, 32.8 mmol) and DMAP. (cat.) in CH2Cl2 (10 ml) was added PPAA as a 50% solution in EtOAc (3.0 ml, 4.92 mmol). The reaction was stirred at room temperature overnight, diluted with EtOAc (100 ml) and washed with sat. NaHCO3 (2*30 ml) and brine (1*30 ml), dried (MgSO4), filtered and concentrated by vacuum. The resultant oil was subjected to flash chromatography (SiO2, biotage, 25% EtOAc/hexanes) to give 5-methyl-isoxazole-4-carboxylic acid [2-(4-methoxy-phenylamino)-phenyl]-amide as an oil (0.729 g, 2.26 mmol, 69%). MS 324 (M+1).

42831-50-5, The synthetic route of 42831-50-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chesworth, Richard; Gegnas, Laura D.; US2004/2524; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem