Day: October 13, 2020

10557-85-4, 3,5-Dimethyl-4-iodoisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under argon protection and liquid nitrogen acetone bath conditions,4-iodo-3,5-dimethylisoxazole (1) (1.12 g, 5 mmol) was dissolved in 50 mL of purified tetrahydrofuran.N-butyllithium (5 mmol, 2.3 mL) was added under rapid stirring,Continue to low temperature reaction for 0.5 hours;Perfluorinated cyclopentene (5 mmol, 0.7 mL) was rapidly injected with high speed stirring,Continue to low temperature reaction after 1.0 hoursThen rose to room temperature, and then add the appropriate amount of water to terminate the reaction.The solvent was removed and extracted with ether. The organic phases were combined,Washed three times with saturated brine and distilled water, and dried overnight without anhydrous MgSO4. The solvent was removed by vacuum rotary evaporation and eluted with petroleum ether as eluant. The product was purified by silica gel column and the product was 3.1 g as an orange liquid. The yield was 71%., 10557-85-4

The synthetic route of 10557-85-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jiangxi Science and Technology Normal University; Pu Shouzhi; Liu Gang; Ma Lele; Fan Congbin; Cui Shiqiang; (15 pag.)CN104945393; (2017); B;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14441-90-8,5-Phenylisoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Thionyl chloride (1.2 mL) was added at 0 C to the 3-phenylisoxazole-5-carboxylic acid 13 or the 5-phenylisoxazole-3-carboxylic acid 14 or the 5-(4-chlorophenyl)isoxazole-3-carboxylic acid 15 or the 3-(4-methylphenyl)isoxazole-5-carboxylic acid 16 (0.3 g, 1.58 mmol). The obtained suspension was stirred and heated at reflux for 16 h and then cooled at 0 C. At this temperature, a new addition of thionyl chloride (1.2 mL) was followed by another heating at reflux for 2 h. The reaction mixture was cooled at room temperature and the thionyl chloride excess was evaporated to dryness in vacuo. Anhydrous THF (2 mL) was added to the crude product. To the resulting solution, cooled at -5 C, was added dropwise a solution of appropriate amine (3.16 mmol) in dry THF (2 mL). The reaction mixture was stirred at room temperature for ca. 90 min (TLC, petroleum ether/ethyl acetate) and then the solid mass was filtered off and washed with THF. The filtrate was evaporated to dryness; the residue was treated with saturated sodium bicarbonate solution (20 mL) and extracted with dichloromethane (3¡Á15 mL). The combined organic phases were dried (Na2SO4) and evaporated to dryness to give the crude product, purified by flash-chromatography to give the desired amide.

14441-90-8, As the paragraph descriping shows that 14441-90-8 is playing an increasingly important role.

Reference£º
Article; Cosimelli, Barbara; Simorini, Francesca; Taliani, Sabrina; La Motta, Concettina; Da Settimo, Federico; Severi, Elda; Greco, Giovanni; Novellino, Ettore; Costa, Barbara; Da Pozzo, Eleonora; Bendinelli, Sara; Martini, Claudia; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4506 – 4520;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

62348-13-4, General procedure: A solution of the corresponding acyl chloride 1-10 (9.18 mmol) in chloroform (25 mL) was slowly added dropwise to a stirred solution of compounds a-c (4.59 mmol) in dry chloroform (40 mL) and pyridine (5 mL). The mixture was stirred for 48 h at room temperature. Solvents were removed under vacuum by rotatory evaporation and the residue was treated with water (100 mL) and purified.

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ibanez, Elena; Plano, Daniel; Font, Maria; Calvo, Alfonso; Prior, Celia; Palop, Juan Antonio; Sanmartin, Carmen; European Journal of Medicinal Chemistry; vol. 46; 1; (2011); p. 265 – 274;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

288-14-2, Isoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 12 4-[5-Benzyloxymethyl-3-(4-fluoro-phenyl)-isoxazol-4-yl]-2-methylsulfanyl-pyrimidine (Compound 8). To a stirred solution of the above compound 7 (13.75 g, 47.7 mmol) and Et3N (14.6 mL, 105 mmol) in EtOH (200 mL), was added a solution of 4-fluoro-benzoylchloride oxime (56 mmol) in EtOH (50 mL) over 30 min. The solution was stirred at 25 C. for 15 min. Then, the solution was heated to reflux for 90 min. The solution was cooled to 25 C. Additional Et3N (7.3 mL, 52 mmol) was added followed by dropwise addition of a solution of 4-fluoro-benzoylchloride oxime (38.5 mmol) in EtOH (50 mL) over 1 h. to drive the reaction to completion. The solution was refluxed for 1 h. until TLC indicated that all of the starting isoxazole was consumed. The solution was cooled to 25 C. and concentrated. The crude material was picked up in CH2Cl2 (50 mL) and poured into saturated aqueous NaHCO3 (150 mL), extracted with CH2Cl2 (3*150 mL), dried (MgSO4), filtered and concentrated. Flash chromatography (SiO2, 20% EtOAc-hexanes) provided the title compound (14.2 g, 34.8 mmol, 60%) in sufficient purity (>85%) for use in the next reaction.

288-14-2, The synthetic route of 288-14-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Green, Jeremy; Bemis, Guy; Grillot, Anne-Laure; Ledeboer, Mark; Salituro, Francesco G.; Harrington, Edmund; Gao, Huai; Baker, Christopher; Cao, Jingrong; Hale, Michael; US2003/149051; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

108511-97-3, Isoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of methyl 2-(5-formyl-2-((2,2,2- trifluoroethyl)amino)pyrimidin-4-yl)-2-(4-methoxyphenyl)acetate (as prepared in General procedure III , Step G) (76 mg, 0.2 mmol, 1.0 equiv), isoxazol-4- amine (42 mg, 0.5 mmol, 2.5 equiv) in DCE/MeOH (3/0.5 mL) was added HOAc (42 mg, 0.7 mmol, 3.5 equiv). The mixture was stirred at 45 C overnight, then the mixture was cooled down to 0C, NaBH3CN (12 mg, 0.2 mmol, 1.0 equiv) was added to the reaction mixture in one portion, after which the resulting mixture was allowed to warm to room temperature and stirred for an additional l2h before being quenched with DCM (10 mL) and H2O (10 mL). The aqueous layer was extracted with DCM (10 mL x 3). The combined organic layers were dried over Na2S04 and concentrated. The residue was purified by Prep-TLC (PE:EA = 1/2) to give 6-(isoxazol-4-yl)-8-(4-methoxyphenyl)-2-((2,2,2- trifluoroethyl)amino)-5,6-dihydropyrido[-/, 3-6/]pyrimidin-7(-/r///)-one (51 mg, 44% yield) as a white solid. LC-MS: m/z 420 [M+H]+., 108511-97-3

As the paragraph descriping shows that 108511-97-3 is playing an increasingly important role.

Reference£º
Patent; AGIOS PHARMACEUTICALS, INC.; KONTEATIS, Zenon D.; LI, Mingzong; LIU, Peng; MEDEIROS, Matthew; REZNIK, Samuel K.; SUI, Zhihua; TRAVINS, Jeremy M.; POPOVICI-MULLER, Janeta; ZHOU, Shubao; MA, Guangning; (298 pag.)WO2019/191470; (2019); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

Compound 6 (14.21g, 30.39mmol) was added to absolute ethanol (150 mL), followed by gradual addition of isoxazol-5-carboxylic acid chloride (35mmol), stirring the reaction was warmed to reflux.After about 8 hours, the reaction was completed and TLC was used to monitor the end of the reaction.After the reactionsolution was allowed to stand for cooling, suction filtration, and the filter cake was washed with a small amount of anhydrous ethanol to obtain a white solid product N-(((4-(diphenyl[b,d]thiophen-3-yl)-7-) Oxy-2,2-dimethylpyridin-3-yl)methyl)sulfonyl)isoxazole-5-carboxamide, 15.73 g,yield 92%.

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zeng Qingqiang; (12 pag.)CN108586445; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

36958-61-9, 5-(Bromomethyl)-3-methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirred suspension of12(1 g, 3.9 mmol), 5-(bromomethyl)-3-methyl-1,2-oxazole (0.48 mL, 4.3 mmol) and potassium carbonate (1.13 g, 8.2 mmol) in DMF (10 mL) was heated to 80 C for 4 h. After cooling to room temperature the reaction mixture was added to ice-water (100 mL) and stirred for 30 min. The resulting pink precipitate was collected by filtration to afford the title compound (0.89 g, 65%) as a pink powder. 1H NMR (300 MHz, DMSO-d6) delta 8.05-8.00 (m, 2H), 7.94-7.88 (m, 2H), 6.65 (s, 1H), 6.60 (s, 1H), 5.54 (s, 2H), 4.32 (q,J= 7.1 Hz, 2H), 2.25 (s, 3H), 1.31 (t,J= 7.1 Hz, 3H). LC-MS: (High pH) tR1.11 min,m/z351.2 [M-H]-, 96% purity, 36958-61-9

As the paragraph descriping shows that 36958-61-9 is playing an increasingly important role.

Reference£º
Article; Mould, Daniel P.; Bremberg, Ulf; Jordan, Allan M.; Geitmann, Matthis; Maiques-Diaz, Alba; McGonagle, Alison E.; Small, Helen F.; Somervaille, Tim C.P.; Ogilvie, Donald; Bioorganic and Medicinal Chemistry Letters; vol. 27; 14; (2017); p. 3190 – 3195;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3209-71-0,Isoxazole-3-carboxylic Acid,as a common compound, the synthetic route is as follows.

Amine 32-1 (73 mg, 0.209 mmol) was added to anhydrous dimethylformamide (2.0 mL). Isoxazole-3-carboxylic acid (23.6 mg, 0.209 mmol), EDC (40.1 mg, 0.209 mmol), HOBT (32 mg, 0.209 mmol) and triethylamine (58 0.418 mmol) were added sequentially and the resulting reaction mixture was allowed to stir at room temperature for 18 h. Following this duration, the contents were filtered and the resulting filtrate was purified via reverse-phase HPLC (5-95%, 0.1% TFA in H20:acetonitrile) to give 32-2 as a white solid. MS m/z (M+H): calculated = 445.1794; observed = 445.1808. NMR delta (ppm)(CHCl3-d): 8.50-8.43 (1 H, m), 7.14 (1 H, d, J = 8.42 Hz), 6.79-6.75 (1 H, m), 6.03 (1 H, d, J = 8.47 Hz), 5.10-5.01 (2 H, m), 4.18-4.08 (2 H, m), 3.90 (1 H, dd, J = 13.05, 3.18 Hz), 3.83-3.66 (3 H, m), 3.58-3.50 (1 H, m), 3.41 (3 H, d, J = 10.20 Hz), 2.15 (2 H, t, J = 14.76 Hz), 1.96 (4 H, d, J = 20.07 Hz).

3209-71-0, 3209-71-0 Isoxazole-3-carboxylic Acid 11286453, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LAYTON, Mark, E.; PERO, Joseph, E.; RODZINAK, Kevin, J.; ROSSI, Michael, A.; WO2011/34741; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228690-37-6,(R)-1-Phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate,as a common compound, the synthetic route is as follows.

To a stirred solution of III-3 (190.9 mg, 0.64 mmol), III-4 (290.7 mg, 0.72 mmol), Na2CO3 (128.1 mg, 1.21 mmol) in DME/H2O (20 mL, v/v=3:1) was added Pd(dppf)Cl2 (66.4 mg, 0.09 mmol) under nitrogen. Then the solution was heated to reflux for 4 hours. After concentrated, H2O (5 mL) was added, and the mixture was extracted with EtOAc. The organic layer was combined and washed with brine, dried over Na2SO4, concentrated in vacuo. The residue was purified by column chromatography on silica gel (PE:EA=1:1) to afford III-5 (256 mg, yield: 26.9%)., 1228690-37-6

1228690-37-6 (R)-1-Phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate 66660383, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/200215; (2014); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

3405-77-4, 5-Methylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: N-protected-amino acid-OH or N-protected-peptide-OH (1?equiv) was dissolved in ? THF and cooled to??15?¡ãC. To the stirred solution, ? N-methylmorpholine (NMM) (1?equiv) and ? isobutylchloroformate (1?equiv) were added consecutively. After precipitation of ? N-methylmorpholine hydrochloride, the amine (1?equiv) was added and the mixture was allowed to warm to 25?¡ãC within 30?min. It was stirred for additional 90?min, and the solvent was removed under reduced pressure. The residue was dissolved in EtOAc and the solution was washed with H2O, saturated NaHCO3, 5percent citric acid and brine. The solvent was dried (MgSO4) and evaporated. The crude residue was purified by flash column chromatography to give the product.

3405-77-4, The synthetic route of 3405-77-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chuck, Chi-Pang; Chen, Chao; Ke, Zhihai; Chi-Cheong Wan, David; Chow, Hak-Fun; Wong, Kam-Bo; European Journal of Medicinal Chemistry; vol. 59; (2013); p. 1 – 6;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem