Month: October 2020

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, To a solution of CH30NHCH3. HCI (780mg) and acid chloride (1g) in CH2CI2 at 0 C was added dry pyridine (1. 35ml) to afford a heterogenous mixture The solution was warmed to room temperature and stirred overnight. 1 M HCI was added to the reaction and the organic layer was separated, washed with brine, dried with Na2SO4, filtered, and concentrated in vacuo to give 1 g of product (85%).

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/68460; (2005); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, To a solution of the above material (0.300 g, 0.708 mmol) in CH2Cl2 (3 mL), isoxazole-5-carbonyl chloride (0.1024 g, 0.78 mmol) and triethylamine (0.13 mL, 0.92 mmol) were added. The resulting solution was stirred at room temperature overnight, and partitioned between CH2Cl2 and water. The organic extract was washed with brine, dried over Na2SO4, filtered and concentrated. The residue was subjected to silica gel chromatography eluted with 10-40% ethyl acetate in hexanes to provide the title compound that gave a proton NMR spectrum consistent with theory and a mass ion (ES+) of 519.3 for M+H+(35Cl): 1H NMR (300 MHz, MeOH-d4) delta 8.59 (s, 1H), 7.83 (d, J=5.6 Hz, 1H), 7.60 (q, J=8.0 Hz, 1H), 7.31-7.23 (m, 4H), 7.11 (s, 1H), 7.02 (d, J=8.1 Hz, 1 H), 6.69 (d, J=5.6 Hz, 1 H), 5.23 (q, J=6.8 Hz, 1H), 4.86 (s, 3H), 1.48 (d, J=7.0 Hz, 3H).

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Kuduk, Scott D.; Bock, Mark G.; Feng, Dong-Mei; Wai, Jenny Miu-Chun; US2004/29920; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33282-15-4,5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 39 5-(4-Hydroxy-phenyl)-isoxazole-3-carboxylic acid {2-[4-(5-fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-amide DIPEA (153 mg, 0.2 mL, 1.18 mmol) followed by HOBT (48 mg, 0.35 mmol) and EDCI (69 mg, 0.35 mmol) were added to a stirred solution of 5-(4-Hydroxy-phenyl)-isoxazole-3-carboxylic acid (69.3 mg, 0.34 mmol) (prepared according to a procedure similar to that described in synthesis procedure 3, steps 1-4-b, using 1-(4-hydroxyphenyl)ethanone (Aldrich, St. Louis, Mo.) as starting material) in DMF (2 mL) at room temperature. After 2 minutes 2-Amino-1-[4-(5-fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethanone hydrochloride salt (prepared according to a procedure similar to that described in synthesis procedure 1, using 5-Fluoro-2-trifluoromethyl-benzoic acid (Aldrich, St. Louis, Mo.) as a starting material) (125 mg, 0.34 mmol) was added and the resulting mixture was stirred at room temperature overnight. Cold water was then added and extracted with ethyl acetate. The organic layer was washed with brine and dried over Na2SO4, concentrated under reduced pressure to afford the residue. The residue obtained was purified by stirring in ethyl acetate at room temperature for 10 minutes and then filtered to afford 101 mg (57.3%) of 5-(4-Hydroxy-phenyl)-isoxazole-3-carboxylic acid {2-[4-(5-fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-amide. LCMS Purity: 93.08%. 1H NMR (DMSO-d6): delta 10.2 (s, 1H), 8.6 (t, 1H), 7.9 (m, 1H), 7.76 (d, 2H), 7.5 (m, 2H), 7.16 (s, 1H), 6.9 (d, 2H), 4.1 (m, 2H), 3.4 (m, 6H), 3.0 (m, 2H).

33282-15-4, As the paragraph descriping shows that 33282-15-4 is playing an increasingly important role.

Reference£º
Patent; Bischoff, Alexander; Subramanya, Hosahalli; Sundaresan, Kumar; Sammeta, Srinivasa Raju; Vaka, Anil Kumar; US2010/160323; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, Gemaess der allgemeinen Arbeitsvorschrift F werden 50 mg (0.14 mmol) [7- (3-AMINO-] [PHENYL)-N [ (3R)-1-AZABICYCLO] [2.2. 2] [OCT-3-YL]-1-BENZOFURAN-2-CARBOXAMID] (Beispiel 114) und [36.] 4 mg (0.28 mmol) [5-ISOXAZOLCARBONSaeURECHLORID] miteinander umgesetzt. Es werden 39.6 mg (53.3 % d. Th. ) der Titelverbindung erhalten. HPLC (Methode [1)] : Rt=4. 18 min. MS (ESIpos) : m/z = 457 (M+H) + (freie Base).

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; BAYER HEALTHCARE AG; WO2003/104227; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

3405-77-4, 5-Methylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 470mg of compound 7 was dissolved in 2ml of dichloromethane was added 0.7mL TFA, stirred at room temperature for 2 to 4 hours, and after completion of the reaction, the solvent was distilled off under reduced pressure, drained oil pump, the oil was dissolved in 2mL of dichloromethane , and then added sequentially 0.8mL triethylamine, 0.11 g of0.14 g of of HOBT and 0.2g EDCI, the reaction system was stirred for 8 to 12 hours at room temperature, after completion of the reaction, successively with 1M hydrochloric acid, saturated sodium bicarbonate, saturated brine , organic phase was collected, dried over anhydrous sodium sulfate, and then filtered to remove the sodium sulfate, the organic phase was collected and the solvent was distilled off under reduced pressure, column chromatography on flash silica gel to give compound 9 0.41g, 85percent yield.

3405-77-4, As the paragraph descriping shows that 3405-77-4 is playing an increasingly important role.

Reference£º
Patent; Tianjin International Biology Medicine United Academe; Rao, Zihe; Fu, Cheng; Yang, Haitao; Yang, Cheng; Cai, Yan; Wang, Zhe; Liu, He; Li, shuang; (30 pag.)CN105837487; (2016); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

206055-91-6, (3-(4-Bromophenyl)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: Preparation of (3-(4-(4,4,5,5-tetramethvI-l,3,2-dioxaboroIan-2- vI)phenvI)isoxazoI-5-yl)methanoI (llh)(3-(4-bromophenyl)isoxazol-5-yl)methanol (300 mg, 1.18 mmol), bis(pinacolato)diboron (750 mgs 3 mol), bis(diphenylphosphino)ferrocene dichloropalladium(193 mg, 0.24 mmol), and potassium acetate (348 mg, 3.54 mmol) were added to N,N- dimethylformamide (4 mL), followed by reaction at 90 C for 2 hours. After completion of the reaction was confirmed by TLC5 the reactants were filtered through celite. The filtrate was extracted with water (20 mL) and ethyl acetate (50 mL). The organic layer was washed with water (10 mL X 2) and brine (10 mL). The organic layer was separated, dried over anhydrous magnesium sulfate, and filtered under reduced pressure to remove ethyl acetate. The residue was purified by silica gel column chromatography using ethyl acetate and hexane as a developing solvent, thus affording the title compound (3-(4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)isoxazol-5-yl)methanol (Hh). Yield: 60%.1U NMR(CDCl3, 400MHz): 7.88(d, 2H, J=8.0Hz), 7.79(d, 2H, J=7.6Hz), 6.58(s, IH), 4.81(s, 2H), and l.25(s, 12H)., 206055-91-6

As the paragraph descriping shows that 206055-91-6 is playing an increasingly important role.

Reference£º
Patent; DONG-A PHARM. CO., LTD.; YUHAN CO., LTD.; WO2008/108602; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

62348-13-4, To a solution of CH3ONHCH3.HCl (780 mg) and acid chloride (19) in CH2Cl2 at 0 C. was added dry pyridine (1.35 ml) to afford a heterogenous mixture The solution was warmed to room temperature and stirred overnight. 1 M HCl was added to the reaction and the organic layer was separated, washed with brine, dried with Na2SO4, filtered, and concentrated in vacuo to give 1 g of product (85%).

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; Schering Corporation; US2004/106794; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

14441-90-8, 5-Phenylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Thionyl chloride (1.2 mL) was added at 0 C to the 3-phenylisoxazole-5-carboxylic acid 13 or the 5-phenylisoxazole-3-carboxylic acid 14 or the 5-(4-chlorophenyl)isoxazole-3-carboxylic acid 15 or the 3-(4-methylphenyl)isoxazole-5-carboxylic acid 16 (0.3 g, 1.58 mmol). The obtained suspension was stirred and heated at reflux for 16 h and then cooled at 0 C. At this temperature, a new addition of thionyl chloride (1.2 mL) was followed by another heating at reflux for 2 h. The reaction mixture was cooled at room temperature and the thionyl chloride excess was evaporated to dryness in vacuo. Anhydrous THF (2 mL) was added to the crude product. To the resulting solution, cooled at -5 C, was added dropwise a solution of appropriate amine (3.16 mmol) in dry THF (2 mL). The reaction mixture was stirred at room temperature for ca. 90 min (TLC, petroleum ether/ethyl acetate) and then the solid mass was filtered off and washed with THF. The filtrate was evaporated to dryness; the residue was treated with saturated sodium bicarbonate solution (20 mL) and extracted with dichloromethane (3¡Á15 mL). The combined organic phases were dried (Na2SO4) and evaporated to dryness to give the crude product, purified by flash-chromatography to give the desired amide., 14441-90-8

14441-90-8 5-Phenylisoxazole-3-carboxylic acid 151916, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Cosimelli, Barbara; Simorini, Francesca; Taliani, Sabrina; La Motta, Concettina; Da Settimo, Federico; Severi, Elda; Greco, Giovanni; Novellino, Ettore; Costa, Barbara; Da Pozzo, Eleonora; Bendinelli, Sara; Martini, Claudia; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4506 – 4520;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

19788-36-4, (3,5-Dimethyl-4-isoxazolyl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

19788-36-4, The titled compound was prepared by the reaction of 2-chloro-3-(4-nitrophenyl)pyrazine (Step 1 of intermediate 11) (112 mg, 0.48 mmol) with (3,5-dimethylisoxazol-4-yl)methanol (61 mg, 0.48 mmol) using cesium fluoride (216 mg, 1.43 mmol) in DMSO (8.0 mL) as per the procedure described in Step 1 of Intermediate 51 to yield 109 mg of the product; 1H NMR (300 MHz, DMSO-d6) delta 2.22 (s, 3H), 2.45 (s, 3H), 5.33 (s, 2H), 8.22 (d, = 8.7 Hz, 2H), 8.32-8.38 (m, 3H), 8.43 (s, 1H).

The synthetic route of 19788-36-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; DAS, Sanjib; GHARAT, Laxmikant Atmaram; HARDE, Rajendra Laxman; SHELKE, Sandeep Yadunath; PARDESHI, Shailesh Ramesh; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; BAJPAI, Malini; (181 pag.)WO2017/21879; (2017); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2552-54-7,3-(Benzyloxy)isoxazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

a) Synthesis of (3-benzyloxy-isoxazol-5-yl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone To 10 ml of anhydrous tetrahydrofuran, 3-benzyloxy-isoxazol-5-carboxylic acid (50 mg, 0.23 mmol) and a catalytic amount of N,N-dimethyl formamide were added and dissolved, and then oxalyl chloride (35 mg, 0.28 mmol) was slowly added thereto and then stirred at room temperature for 4 hours. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in dichloromethane, triethylamine (115 mg, 1.15 mmol) and 3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine (31 mg, 0.23 mmol) were added thereto and then stirred at room temperature for 2 hours. After completion of the reaction by adding water dropwise, the reaction mixture was extracted with dichloromethane, and the combined organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and evaporated under reduced pressure. The residue was purified by column chromatography on amine silica eluding with a solvent of dichloromethane_methanol=30:1. The fractions containing the product were collected and evaporated to obtain (3-benzyloxy-isoxazol-5-yl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone as pale-brown liquid (55 mg, 54% in two steps). 1H-NMR (CDCl3, 300 MHz); delta=8.23 (d, 1H, J=5.3 Hz), 7.32-7.48 (m, 6H), 6.87 (d, 1H, J=5.3 Hz), 6.52 (br s, 1H), 5.30 (s, 2H), 4.44 (m, 2H), 4.13 (m, 2H). MS (ESI); 338.1 (M++1).

2552-54-7, The synthetic route of 2552-54-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ahn, Sung Oh; Park, Chan Hee; Im, Jun Hwan; Lee, Soon Ok; Lee, Kyoung June; Cho, Seong Wook; Ko, Kwang Seok; Han, Sun Young; Lee, Won Il; US2011/28467; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem