Category: 206055-91-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.206055-91-6,(3-(4-Bromophenyl)isoxazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

General procedure: In 100 mL three-necked flask, (3-substituted phenylisoxazol-5-yl)methanols (3a-l) (5 mmol) was poured into a stirred mixture of sodium hydride (15 mmol) and anhydrous THF (10 mL) previously cooled in glacial bath. Propargyl bromide (6 mmol, 0.47 mL) was added, and the mixture was stirred at room temperature (20-25 C) until the reaction was over by TLC monitoring. The slurry was filtrated by sabouraud funnel. Filtrate was evaporated under a vacuum to provide the crude product which was purified by column chromatography (silica gel, 200-300 mesh) using petroleum ether/ethyl acetate (phir = 4:1) to furnish the desired product 4a-l in 68-96% yield.

206055-91-6, As the paragraph descriping shows that 206055-91-6 is playing an increasingly important role.

Reference£º
Article; Zhang, Da-wei; Zhang, Yu-min; Li, Jing; Zhao, Tian-qi; Gu, Qiang; Lin, Feng; Ultrasonics Sonochemistry; vol. 36; (2017); p. 343 – 353;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.206055-91-6,(3-(4-Bromophenyl)isoxazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

General procedure: (0.184 g,1 mmol) was added into a 25 mL one-necked round-bottom flask with 5mL of dry iso-PrOH, and the mixture was stirred in a cold bath. Then a solution of Et3N (0.101 g, 1 mmol) and (3-phenyl-isoxazole-5-yl)-methanol (0.175 g, 1 mmol) in 10mL dry iso-PrOH was slowly added to the reaction system using a syringe. The mixture was stirred in a cold bath for an additional 30 min, and then tem-perature was allowed to reach room temperature. After reaction completion (monitored by thin layer chromatography, TLC), the reaction mixture was evaporated under reduced pressure, and the residue was purified by column chromatog-raphy on silica gel using petroleum ether and ethyl acetate (V/V, 5:1?2:1) as eluant. Fractions with similar Rf values were combined to obtain the target compound 3a., 206055-91-6

206055-91-6 (3-(4-Bromophenyl)isoxazol-5-yl)methanol 11032412, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Yong, Jianping; Lu, Canzhong; Wu, Xiaoyuan; Letters in drug design and discovery; vol. 15; 5; (2018); p. 463 – 474;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

206055-91-6, (3-(4-Bromophenyl)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: Preparation of (3-(4-(4,4,5,5-tetramethvI-l,3,2-dioxaboroIan-2- vI)phenvI)isoxazoI-5-yl)methanoI (llh)(3-(4-bromophenyl)isoxazol-5-yl)methanol (300 mg, 1.18 mmol), bis(pinacolato)diboron (750 mgs 3 mol), bis(diphenylphosphino)ferrocene dichloropalladium(193 mg, 0.24 mmol), and potassium acetate (348 mg, 3.54 mmol) were added to N,N- dimethylformamide (4 mL), followed by reaction at 90 C for 2 hours. After completion of the reaction was confirmed by TLC5 the reactants were filtered through celite. The filtrate was extracted with water (20 mL) and ethyl acetate (50 mL). The organic layer was washed with water (10 mL X 2) and brine (10 mL). The organic layer was separated, dried over anhydrous magnesium sulfate, and filtered under reduced pressure to remove ethyl acetate. The residue was purified by silica gel column chromatography using ethyl acetate and hexane as a developing solvent, thus affording the title compound (3-(4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)isoxazol-5-yl)methanol (Hh). Yield: 60%.1U NMR(CDCl3, 400MHz): 7.88(d, 2H, J=8.0Hz), 7.79(d, 2H, J=7.6Hz), 6.58(s, IH), 4.81(s, 2H), and l.25(s, 12H)., 206055-91-6

As the paragraph descriping shows that 206055-91-6 is playing an increasingly important role.

Reference£º
Patent; DONG-A PHARM. CO., LTD.; YUHAN CO., LTD.; WO2008/108602; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

206055-91-6, (3-(4-Bromophenyl)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of (3-(4-bromophenyl)isoxazol-5-yl)methanol (AA; 0.5 g, 1.96 mmol) in CH2CI2 (15 mL) under inert atmosphere were added pyridine (0.39 mL, 4.91 mmol) and p- dimethylaminopyridine (0.024 mg, 0.19 mmol) at 0 C. After the addition of 4-nitrophenyl carbonochloridate (DK; 0.39 g, 1.93 mmol) at 0 C, the reaction mixture was warmed to RT and stirred for 12 h. The reaction was monitored by TLC. After complete consumption of the starting material, the reaction mixture was diluted with a saturated ammonium chloride solution (20 mL) and the compound was extracted with CH2CI2 (3×20 mL). The combined organic extracts were washed with water (20 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude. The crude was triturated with pentane (2×15 mL) to afford crude DL (710 mg) as an off-white solid. FontWeight=”Bold” FontSize=”10″ H NMR (500 MHz, CDCI3): delta 8.30 (d, / = 9.5 Hz, 2H), 8.17 (d, J = 6.8 Hz, 1H), 7.70-7.59 (m, 5H), 7.40 (d, J = 9.5 Hz, 2H), 6.91 (d, / = 9.0 Hz, 1H), 6.73 (s, 1H), 5.43 (s, 2H), 5.34 (s, 1H).

206055-91-6, 206055-91-6 (3-(4-Bromophenyl)isoxazol-5-yl)methanol 11032412, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; VIAMET PHARMACEUTICALS, INC.; HOEKSTRA, William, J.; YATES, Christopher, M.; RAFFERTY, Stephen, W.; WO2014/117090; (2014); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.206055-91-6,(3-(4-Bromophenyl)isoxazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

3-(4-bromophenyl)isoxazol-5-yl)methanol (5.0 g, 19.7 mmol) synthesized in Step 1 of Preparation Example 7, and 60% sodium hydride (1 g) were added to N,N-dimethylformamide (50 mL) and the mixture was stirred for 15 min. After methyl iodide was added thereto and completion of the reaction was confirmed by TLC, extraction was carried out with water (20 mL) and ethyl acetate (100 mL). The organic layer was washed with water (50 mL¡Á2) and brine (20 mL). The organic layer was separated, dried over anhydrous magnesium sulfate, and filtered under reduced pressure to remove ethyl acetate. The residue was purified by silica gel column chromatography using ethyl acetate and hexane as a developing solvent, thus affording the title compound 3-(4-bromophenyl)-5-(methoxymethyl)isoxazole (11f). Yield: 95%.1H NMR (CDCl3, 400 MHz): 7.67 (d, 2H, J=7.2 Hz), 7.58 (d, 2H, J=7.6 Hz), 6.53 (s, 1H), 4.57 (s, 2H), and 3.45 (s, 3H).

206055-91-6, As the paragraph descriping shows that 206055-91-6 is playing an increasingly important role.

Reference£º
Patent; Moon, Ho-Sang; Yoo, Moo-Hi; Kim, Soon-Hoe; Lim, Joong-In; Son, Moon-Ho; Kim, Mi-Kyung; Shin, Chang-Yell; Kim, Jin-Kwan; Park, Sang-Kuk; Chae, Yu-Na; Shim, Hyun-Joo; Jeon, Sun-Ho; Kim, Hae-Sun; Wie, Gil-Tae; Kim, Dong-Hwan; Lee, Byung-Kyu; Park, Chan-Sun; Ahn, Byung-Nak; Kim, Eunkyung; Bae, Myung-Ho; Shin, Young-Ah; Hur, Youn; Lee, Chun-Ho; Choi, Hyun-Ho; Kim, Bongtae; Chong, Wonee; US2010/63041; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem