Tag: M.W:100-200

59669-59-9, 3-(tert-Butyl)isoxazol-5-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,59669-59-9

General procedure: To a stirred solution of ynamide 4a (57.0 mg, 0.2 mmol) in DCE (2.0 mL, 0.1 M) was added isoxazol-5-amine 8a (21.6 mg, 0.22 mmol, 1.1 equiv), followed by AgNTf2 (3.9 mg, 5 mol %). The resulting mixture was placed into an oil bath of 80 C with stirring for 2 h generally, monitoredby TLC. After completion, the reaction mixture was cooled and the desired product was precipitated. The solid was filtered and washed with DCM twice, then dried in a vacuum drying oven at 50 C for 24 h to give the pure pyrrole product 10aa, 75.8 mg, 99% yield. For products 10ab-ae, 10ka-la, the purification method was as follows: evaporation of volatiles under reduced pressure to give the residue, which was suffered from column chromatographyon silica gel (petrol ether/ethyl acetate 1:1-1:2, v/v) to afford the pure pyrrole.

As the paragraph descriping shows that 59669-59-9 is playing an increasingly important role.

Reference£º
Article; Cao, Ziping; Zhu, Jiekun; Liu, Li; Pang, Yuanling; Tian, Laijin; Sun, Xuejun; Meng, Xin; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 2623 – 2630;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.,62348-13-4

Compound 6 (11.8g, 28.06mmol) was added to absolute ethanol (150 mL), followed by gradual addition of isoxazole-5-carbonyl chloride (10.2g, 77.55mmol), The reaction was heated to reflux with stirring. After about 8 hours, the reaction was completed and TLC was used to monitor the end of the reaction.point. After the reaction solution was allowed to stand for cooling, suction filtration, and the filter cake was washed with a small amount of anhydrous ethanol to obtain a white solid product N-(((4-(2,3-dihydro-[1,4]dioxacyclohexane) Alkeno[2,3-b]pyridin-7-yl)-7-methoxy-2,2-dimethylpyridin-3-yl)methyl)sulfonyl)isoxazole-5-carboxamide, 13.8 g, yield 95.6%.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; Zeng Qingqiang; (11 pag.)CN108570056; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

123770-62-7, Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (50.0 mg, 0.29 mmol) in DCM (2 mL) was added diethylaminosulfur trifluoride (70.6 mg, 0.06 ml, 0.44 mmol). The mixture was stirred at 40 C for 1 hour. Water (3 mL) was added and the mixture was extracted with ethyl acetate (5 mLchi3). The combined organic layers were washed with brine (5 mL), dried over Na2S04and concentrated. The crude mixture was purified by flash chromatography with heptane:ethyl acetate = 1 :0 to 0:1 to give ethyl 5- (fluoromethyl)isoxazole-3-carboxylate (41 .0 mg).

123770-62-7, The synthetic route of 123770-62-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (270 pag.)WO2018/7249; (2018); A1;,
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Isoxazole | C3H3NO – PubChem

21169-71-1, Isoxazole-5-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of isoxazole-5-carboxylic acid (2.5 g 22.1 mmol), sodium bicarbonate (5.57 g, 66.32 mmol) and iodomethane (8.26 mL, 132.65 mmol) in DMF (30 mL) was stirred at 25 C. over 19 h. The mixture was diluted in H2O (30 mL) and extracted with ether (2¡Á50 mL). The ether layer washed with brine, dried over MgSO4, filtered, concentrated in vacuo to obtain a crude oil. The crude was further purified by Biotage chromatography (cartridge 40m), eluent EtOAc-Hexanes (1:2), then 100% EtOAc to obtain isoxazole-5-carboxylic acid methyl ester as an amorphous solid (1.2 g, 42.7%). Mass Spectrum (+ESI): 128 (M+H)+., 21169-71-1

The synthetic route of 21169-71-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth; US2007/219186; (2007); A1;,
Isoxazole – Wikipedia
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19788-36-4, (3,5-Dimethyl-4-isoxazolyl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

19788-36-4, The titled compound was prepared by the reaction of 2-chloro-3-(4-nitrophenyl)pyrazine (Step 1 of intermediate 11) (112 mg, 0.48 mmol) with (3,5-dimethylisoxazol-4-yl)methanol (61 mg, 0.48 mmol) using cesium fluoride (216 mg, 1.43 mmol) in DMSO (8.0 mL) as per the procedure described in Step 1 of Intermediate 51 to yield 109 mg of the product; 1H NMR (300 MHz, DMSO-d6) delta 2.22 (s, 3H), 2.45 (s, 3H), 5.33 (s, 2H), 8.22 (d, = 8.7 Hz, 2H), 8.32-8.38 (m, 3H), 8.43 (s, 1H).

The synthetic route of 19788-36-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; DAS, Sanjib; GHARAT, Laxmikant Atmaram; HARDE, Rajendra Laxman; SHELKE, Sandeep Yadunath; PARDESHI, Shailesh Ramesh; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; BAJPAI, Malini; (181 pag.)WO2017/21879; (2017); A1;,
Isoxazole – Wikipedia
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14441-90-8, 5-Phenylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Thionyl chloride (1.2 mL) was added at 0 C to the 3-phenylisoxazole-5-carboxylic acid 13 or the 5-phenylisoxazole-3-carboxylic acid 14 or the 5-(4-chlorophenyl)isoxazole-3-carboxylic acid 15 or the 3-(4-methylphenyl)isoxazole-5-carboxylic acid 16 (0.3 g, 1.58 mmol). The obtained suspension was stirred and heated at reflux for 16 h and then cooled at 0 C. At this temperature, a new addition of thionyl chloride (1.2 mL) was followed by another heating at reflux for 2 h. The reaction mixture was cooled at room temperature and the thionyl chloride excess was evaporated to dryness in vacuo. Anhydrous THF (2 mL) was added to the crude product. To the resulting solution, cooled at -5 C, was added dropwise a solution of appropriate amine (3.16 mmol) in dry THF (2 mL). The reaction mixture was stirred at room temperature for ca. 90 min (TLC, petroleum ether/ethyl acetate) and then the solid mass was filtered off and washed with THF. The filtrate was evaporated to dryness; the residue was treated with saturated sodium bicarbonate solution (20 mL) and extracted with dichloromethane (3¡Á15 mL). The combined organic phases were dried (Na2SO4) and evaporated to dryness to give the crude product, purified by flash-chromatography to give the desired amide., 14441-90-8

14441-90-8 5-Phenylisoxazole-3-carboxylic acid 151916, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Cosimelli, Barbara; Simorini, Francesca; Taliani, Sabrina; La Motta, Concettina; Da Settimo, Federico; Severi, Elda; Greco, Giovanni; Novellino, Ettore; Costa, Barbara; Da Pozzo, Eleonora; Bendinelli, Sara; Martini, Claudia; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4506 – 4520;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

62348-13-4, To a solution of CH3ONHCH3.HCl (780 mg) and acid chloride (19) in CH2Cl2 at 0 C. was added dry pyridine (1.35 ml) to afford a heterogenous mixture The solution was warmed to room temperature and stirred overnight. 1 M HCl was added to the reaction and the organic layer was separated, washed with brine, dried with Na2SO4, filtered, and concentrated in vacuo to give 1 g of product (85%).

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; Schering Corporation; US2004/106794; (2004); A1;,
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3405-77-4, 5-Methylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 470mg of compound 7 was dissolved in 2ml of dichloromethane was added 0.7mL TFA, stirred at room temperature for 2 to 4 hours, and after completion of the reaction, the solvent was distilled off under reduced pressure, drained oil pump, the oil was dissolved in 2mL of dichloromethane , and then added sequentially 0.8mL triethylamine, 0.11 g of0.14 g of of HOBT and 0.2g EDCI, the reaction system was stirred for 8 to 12 hours at room temperature, after completion of the reaction, successively with 1M hydrochloric acid, saturated sodium bicarbonate, saturated brine , organic phase was collected, dried over anhydrous sodium sulfate, and then filtered to remove the sodium sulfate, the organic phase was collected and the solvent was distilled off under reduced pressure, column chromatography on flash silica gel to give compound 9 0.41g, 85percent yield.

3405-77-4, As the paragraph descriping shows that 3405-77-4 is playing an increasingly important role.

Reference£º
Patent; Tianjin International Biology Medicine United Academe; Rao, Zihe; Fu, Cheng; Yang, Haitao; Yang, Cheng; Cai, Yan; Wang, Zhe; Liu, He; Li, shuang; (30 pag.)CN105837487; (2016); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, Gemaess der allgemeinen Arbeitsvorschrift F werden 50 mg (0.14 mmol) [7- (3-AMINO-] [PHENYL)-N [ (3R)-1-AZABICYCLO] [2.2. 2] [OCT-3-YL]-1-BENZOFURAN-2-CARBOXAMID] (Beispiel 114) und [36.] 4 mg (0.28 mmol) [5-ISOXAZOLCARBONSaeURECHLORID] miteinander umgesetzt. Es werden 39.6 mg (53.3 % d. Th. ) der Titelverbindung erhalten. HPLC (Methode [1)] : Rt=4. 18 min. MS (ESIpos) : m/z = 457 (M+H) + (freie Base).

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; BAYER HEALTHCARE AG; WO2003/104227; (2003); A1;,
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Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, To a solution of the above material (0.300 g, 0.708 mmol) in CH2Cl2 (3 mL), isoxazole-5-carbonyl chloride (0.1024 g, 0.78 mmol) and triethylamine (0.13 mL, 0.92 mmol) were added. The resulting solution was stirred at room temperature overnight, and partitioned between CH2Cl2 and water. The organic extract was washed with brine, dried over Na2SO4, filtered and concentrated. The residue was subjected to silica gel chromatography eluted with 10-40% ethyl acetate in hexanes to provide the title compound that gave a proton NMR spectrum consistent with theory and a mass ion (ES+) of 519.3 for M+H+(35Cl): 1H NMR (300 MHz, MeOH-d4) delta 8.59 (s, 1H), 7.83 (d, J=5.6 Hz, 1H), 7.60 (q, J=8.0 Hz, 1H), 7.31-7.23 (m, 4H), 7.11 (s, 1H), 7.02 (d, J=8.1 Hz, 1 H), 6.69 (d, J=5.6 Hz, 1 H), 5.23 (q, J=6.8 Hz, 1H), 4.86 (s, 3H), 1.48 (d, J=7.0 Hz, 3H).

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Kuduk, Scott D.; Bock, Mark G.; Feng, Dong-Mei; Wai, Jenny Miu-Chun; US2004/29920; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem