Tag: M.W:100-200

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, To a solution of CH30NHCH3. HCI (780mg) and acid chloride (1g) in CH2CI2 at 0 C was added dry pyridine (1. 35ml) to afford a heterogenous mixture The solution was warmed to room temperature and stirred overnight. 1 M HCI was added to the reaction and the organic layer was separated, washed with brine, dried with Na2SO4, filtered, and concentrated in vacuo to give 1 g of product (85%).

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/68460; (2005); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

3405-77-4, 5-Methylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 111N-((ls,4s)-4-(2-(4′-(((3S,5R)-3,5-dimethylpiperazin-l-yl)methyl)biphenyl-3-yloxy)-5- fluoronicotinamido)cyclohexyl)-5-methylisoxazole-3-carboxamide HATU (0.104 g, 0.27 mmol) was added to a solution of 5-methylisoxazole-3-carboxylic acid (0.035 g, 0.27 mmol), N-((ls,4s)-4-aminocyclohexyl)-2-(4′-(((3S,5R)-3,5-dimethylpiperazin- l-yl)methyl)biphenyl-3-yloxy)-5-fluoronicotinamide (0.15 g, 0.25 mmol) and DIPEA (0.173 mL, 0.99 mmol) in DMF (5 mL) and the solution stirred at RT for 20 h. The mixture was purified by reverse phase HPLC with aqTFA/MeCN as eluant to the title compound as a white solid. Yield: 47 mg1U NMR (400 MHz, CD3OD) delta 8.45 (d, J = 7.9 Hz, IH), 8.11 (d, J = 3.4 Hz, IH), 8.07 (m, IH), 7.61 (d, J = 8.2 Hz, 2H), 7.49 (d, J = 5.3 Hz, 2H), 7.42 (m, 3H), 7.16 (m, IH), 6.38 (s, IH), 4.13 (m, IH), 3.94 (m, IH), 3.79 (s, 2H), 3.43 (m, 2H), 3.17 (m, 2H), 2.44 (s, 3H), 2.25 (m, 4H), 1.92 – 1.66 (m, 8H), 1.28 (d, J = 6.9 Hz, 6H). MS: APCI (+ve):641 (M+l)., 3405-77-4

3405-77-4 5-Methylisoxazole-3-carboxylic acid 76947, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

21169-71-1, Isoxazole-5-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

21169-71-1, General procedure: To a solution of the benzoxazole core (1.0 eq) in DCM (2 mL) was added the carboxylic acid (1.2 eq), EDCI (1.2 eq) and DMAP (0.1 eq). The solution was stirred under nitrogen at 45 C overnight. Work-up 1 (W1): The solution was extended with DCM, a saturated solution of sodium bicarbonate was added and the mixture was extracted three times with DCM. The combined organic layers were then washed with brine, dried with sodium sulphate and the solvent was removed in vacuo. Purification by column chromatography on silica gel, eluting ethyl acetate/cyclohexane 50:50 led to the desired carboxamide.

The synthetic route of 21169-71-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ferrins, Lori; Rahmani, Raphael; Sykes, Melissa L.; Jones, Amy J.; Avery, Vicky M.; Teston, Eliott; Almohaywi, Basmah; Yin, JieXiang; Smith, Jason; Hyland, Chris; White, Karen L.; Ryan, Eileen; Campbell, Michael; Charman, Susan A.; Kaiser, Marcel; Baell, Jonathan B.; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 450 – 465;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

59669-59-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59669-59-9,3-(tert-Butyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.

To a cold slurry of (S)-1-(4-Chloro-phenyl)-4-oxo-azetidine-2-carboxylic acid (0.2g; 1.037mmol) and 5-amino-3-tert-butylisoxazole (0.145g; 1.037mmol) in pyridine (1.258mL; 15.555mmol) is added phosphorous oxychloride (O.l lbetamL; 1.244mmol). The mixture is stirred at O¡ãC for 30 minutes and then diluted with water and extracted with ethyl acetate several times. The organics are combined and washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo. Purification by preparative HPLC affords title compound, m/z 348 [M+H+]

The synthetic route of 59669-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HICKEY, Eugene, Richard; RIETHER, Doris; THOMSON, David, Smith; WU, Lifen; ZINDELL, Renee, M.; WO2010/147791; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36958-61-9,5-(Bromomethyl)-3-methylisoxazole,as a common compound, the synthetic route is as follows.

Sodium hydride (60% w/w) (34.1 mg, 0.85 mmol) was added to a stirring solution of 7-benzylsulfanyl-4-(cyclopropanecarbonyl)-2H-isoquinolin-1 -one (220. mg, 0.66 mmol) in DMF (8 mL). After 15 min 5-(bromomethyl)-3-methyl-1 ,2-oxazole (0.15 mL, 0.85 mmol) was added and the reaction mixture stirred at ambient temperature for 1 h. DCM (25 mL) and saturated aq. NaHC03 (25 mL) were added and the mixture stirred for 5 min. The DCM layer was isolated by passing through a hydrophobic frit and the aqueous layer washed with DCM. The combined DCM extracts were concentrated under reduced pressure and purified by automated column chromatography, SiO2, eluent 0-100% EtOAc in iso- Hexane to yield 7-benzylsulfanyl-4-(cyclopropanecarbonyl)-2-[(3-methylisoxazol-5- yl)methyl]isoquinolin-1 -one (263 mg, 0.61 mmol, 93%). Used directly in the synthesis of Intermediate S10-C1, 36958-61-9

As the paragraph descriping shows that 36958-61-9 is playing an increasingly important role.

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; MCGONAGLE, Alison E.; JORDAN, Allan; WASZKOWYCZ, Bohdan; HUTTON, Colin; WADDELL, Ian; HITCHIN, James R.; SMITH, Kate Mary; HAMILTON, Niall M.; (497 pag.)WO2016/92326; (2016); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4,62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-(5-(aminomethyl)-2-chlorophenyl)-1-(4-(trifluoromethyl)phenyl)-1H- 1,2,4-triazol-5(4H)-one (Intermediate-63, 0.060 g, 0.162 mmol) in dry THF ( 5 mL) was added DIPEA (3 mL) and stirred for 20 minutes. The reaction mixture was cooled to 0C and isoxazole-5-carbonyl chloride (0.032 g, 0.243 mmol) was added and stirred for 3 h at room temperature. The reaction mass was quenched in water, extracted with DCM: MeOH and concentrated to afford crude product which was purified by column chromatography eluting with MeOH: DCM to afford 0.030 g of pure product. 1H NMR (400 MHz, DMSO d6): delta 4.50-4.52 (d, J = 8Hz, 2 H), 7.09-7.10 (d, = 2 Hz, 1H), 7.43- 7.45 (d, J = 8.4 Hz, 1H), 7.50-7.53 (d, J = 10.4Hz, 1H), 7.59-7.64 (d, J= 18 Hz, 1H), 7.82-7.85 (d, / = 8.8 Hz, 2H), 8.17-8.19 (d, J = 8.4 Hz, 2H), 8.74-8.75 (d, J – 2Hz, 1H), 9.58-9.61 (t, 1H), 12.61-12.74 (br s, 1H); MS (m/z): 464.11 (M+H+).

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati; WO2013/186692; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

19788-36-4, (3,5-Dimethyl-4-isoxazolyl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-(2,4-dimethylphenyl)-3-hydroxy-N-isobutylbenzenesulfonamide (76.9 mg, 0.231 mmol), (3,5- dimethylisoxazol-4-yl)methanol (36.7 mg, 0.288 mmol) and (4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9, 10, 10, 10-heptadecafluorodecyl)phenyl)diphenylphosphine (204 mg, 0.288 mmol) were added to a 2-5mL Biotage microwave vessel. Tetrahydrofuran (THF) (4 mL) was added followed by diisopropyl diazene-l,2-dicarboxylate (DIAD) (0.056 mL, 0.288 mmol). The reaction vial was sealed and left to stir overnight at RT. The reaction mixture was concentrated in vacuo and then diluted with ethyl acetate (25mL) and water (25mL). The organic fraction was separated, dried and then concentrated in vacuo to give the crude product. The crude product was dissolved in DMF: H20 (9: 1) ImL, and loaded onto a flurous column(preconditioned with ImL DMF, followed by 6mL MeOH: H20 (5: 1). The semi purified fraction was eluted with 6mL MeOH: H20 (5: 1). The fraction was concentrated down, and dissolved in 1: 1 MeOH:DMSO 1 mL and purified by mass directed autoPrep on Sunfire C18 column usingAcetonitrile Water with a Formic acid modifier. The solvent was dried under a stream of nitrogen in the Radleys blowdown apparatus to give the required product, 37.7 mg., 19788-36-4

The synthetic route of 19788-36-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; BIRAULT, Veronique; CAMPBELL, Amanda, Jennifer; HARRISON, Stephen; LE, Joelle; WO2013/45431; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

14441-90-8, 5-Phenylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a solution of (lS)-l-[5-[(3- aminocyclobutyl)methyl]-l,3,4-thiadiazol-2-yl]ethan-l-ol hydrochloride (1.2 g, 4.80 mmol, 1.00 eq.), 5-phenyl-l,2-oxazole-3-carboxylic acid (2.36 g, 12.48 mmol, 2.60 eq.) and HCTU (6.0 g, 14.50 mmol, 3.00 eq.) in dichloromethane (50 mL) was placed in a 100-mL round- bottom flask. This was followed by the addition of DIEA (3.1 g, 23.99 mmol, 5.00 eq.) dropwise with stirring at 0C. The resulting solution was stirred for 4 hours at room temperature. The reaction was then quenched by the addition of 50 mL of water/ice and extracted with dichloromethane (3×50 mL) and the organic layers combined. The resulting mixture was washed with brine (3×30 mL), dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (2: 1). This resulted in 2.1 g (79%) of (lS)-l-(5-[[3-(5-phenyl-l,2- oxazole-3-amido)cyclobutyl]methyl]-l,3,4-thiadiazol-2-yl)ethyl 5-phenyl-l,2-oxazole-3- carboxylate as a off-white solid. LC-MS: (M+H)+ = 556

14441-90-8, The synthetic route of 14441-90-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROTEOSTASIS THERAPEUTICS, INC.; LEE, Po-shun; (180 pag.)WO2017/40606; (2017); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54593-26-9,3,5-Dimethyl-4-isoxazolecarbaldehyde,as a common compound, the synthetic route is as follows.

54593-26-9, (i) methyl 2-(2-((3,5-dimethylisoxazoi-4-yl)(hydroxy)methyl)benzofuran-Syl)acetate: To a solution of methyl 2?(2-brornoberizofuran-5-yl)acetate (2.0 mg, 7.46 nmmnol) in. 50 niL TI-IF at 0 Cwas added i-PrMgC1 (5.6 mE, 11.2 mniol, 2N in THF). The mixture was stirred at 0 C for 30 mm. Then 3,Sdimethylisoxazole4-carbaldehyde (1.5 g, 12 mmol) was added to the mixture. The resulting mixture was stirred for 2 h. Saturated aq. NHCi (10 mL) was added to the mixture and the mixture was extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (3 x 15 mL) and dried over Na2504. The solvent was evaporated to aresidue which was purified by silica gel column chromatography (30% EtOAc/petroleum ether) to afford the title compound (900 mg, yield 38%) as a yellow oil. LCMS-P1: 316 [M+H] R = i.48i mm.

As the paragraph descriping shows that 54593-26-9 is playing an increasingly important role.

Reference£º
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19626; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

14441-90-8, 5-Phenylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

to a solution of 3-(3-[l-[(tert-butyldimethylsilyl)oxy]ethyl]-l,2,4-oxadiazol-5- yl)cyclobutan-l -amine (1.5 g, 5.04 mmol, 1.00 eq.) in dichloromethane (100 mL)was added 5- phenyl-l,2-oxazole-3-carboxylic acid (1.13 g, 5.97 mmol, 1.20 eq.), HATU (2.28 g, 6.00 mmol, 1.20 eq.) and DIEA (1.93 g, 14.93 mmol, 3.00 eq.). The resulting solution was stirred for 1 hour at room temperature. The reaction was then quenched by the addition of water and extracted with ethyl acetate (3×50 mL) and the combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (l :50)to give 300 mg (13%) of 5-phenyl- N-[cw-3-(3-[l-[(tert-butyldimethylsilyl)oxy]ethyl]-l,2,4-oxadiazol-5-yl)cyclobutyl]-l,2- oxazole-3-carboxamide as a white solid. The solvent was changed to a mixture of with ethyl acetate/petroleum ether (1 :20) to give 1.4 g (59%) of 5-phenyl-N-[fra ,-3-(3-[l-[(tert- butyldimethylsilyl)oxy]ethyl]-l,2,4-oxadiazol-5-yl)cyclobutyl]-l,2-oxazole-3-carboxamide as a white solid. LC-MS: (M+H)+ = 469.

14441-90-8, As the paragraph descriping shows that 14441-90-8 is playing an increasingly important role.

Reference£º
Patent; PROTEOSTASIS THERAPEUTICS, INC.; BASTOS, Cecilia, M.; MUNOZ, Benito; TAIT, Bradley; (178 pag.)WO2016/115090; (2016); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem