Tag: M.W:100-200

59669-59-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59669-59-9,3-(tert-Butyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.

To a solution of 5-amino-3-tert-butylisoxazole (0.100 g) in anh toluene (5 mL) was added 4-chloro-3-(trifluoromethyl)phenyl isocyanate (0.395 g). The reaction vessel was sealed, heated at 85 ¡ãC for 24 h, and cooled to room temp. The reaction mixture was added to a slurry of Dowex.(R). 50WX2-100 resin (0.5 g) in CH2Cl2 (40 mL), and the resulting mixture was stirred vigorously for 72 h. The mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (gradient form 100percent CH2Cl2 to 5percent MeOH/95percent CH2Cl2) to give bis(4-chloro-3-(trifluoromethyl)phenyl)urea followed by N-(3-tert-butyl-5-isoxazolyl)-N’-(4-chloro-3-(trifluoromethyl)phenyl)urea. The residue from the symmetrical urea fractions was triturated (Et2O/hexane) to give the urea as a white solid (0.110 g): TLC (3percent MeOH/97percent CH2Cl2) Rf 0.55; FAB-MS m/z 417 ((M+H)+).

59669-59-9 3-(tert-Butyl)isoxazol-5-amine 2095694, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Corporation; EP1449834; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

32326-25-3, 5-Methoxyisoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a reaction flask equipped with a stirrer, a condenser and a thermometer,4.27 g (0.01 mol) of Intermediate IV-2, 2.00 g (0.02 mol) of potassium bicarbonate,30ml of methanol and 1.14g (0.01mol) 5-methoxy-3-aminoisoxazole, the reaction was refluxed 8h,The reaction was complete by TLC, insolubles were filtered off, the solvent was evaporated and the residue was chromatographed on silica gel,Compound I-5 was obtained as a white solid with a yield of 88% and a purity of 99.7% (HPLC normalization method), 32326-25-3

As the paragraph descriping shows that 32326-25-3 is playing an increasingly important role.

Reference£º
Patent; Tianjin Pharmaceutical Institute; Liu Dengke; Liu Ying; Xie Xiaoshuai; Mu Shuai; Zhang Dashuai; Hou Jiajia; Zou Meixiang; (20 pag.)CN103804367; (2016); B;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

21169-71-1, Isoxazole-5-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 85-a (200.00 mg, 1.77 mmol, 1.00 eq) was dissolved in dichloromethane (15.00 mL), and compound 7-a (305.88 mg, 1.95 mmol, 299.88 mL, 1.10 eq), EDCI (464.54 mg, 2.42 mmol, 1.37 eq), HOBt (327.43 mg, 2.42 mmol, 1.37 eq) and NMM (536.75 mg, 5.31 mmol, 583.42 mL, 3.00 eq) were added thereto. The reaction solution was stirred at 10C for 15 hours. After the reaction was completed, the reaction solution was added with water (100 mL), and extracted with dichloromethane (100 mL 3 3). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated to give a crude product. The crude product was subjected to column chromatography (petroleum ether : ethyl acetate = 1:0?2:1) to give the product of compound 85-b (380.00 mg, yield: 85%) as a colorless oil. 1H NMR (400 MHz, CHLOROFORM-d) delta=8.31 (d, J=1.51 Hz, 1H), 6.75 (d, J=1.51 Hz, 1H), 4.44 (d, J=13.05 Hz, 1H), 4.14-4.22 (m, 2H), 4.08 (d, J=12.55 Hz, 1H), 3.30 (t, J=11.29 Hz, 1H), 3.10 (t, J=11.04 Hz, 1H), 2.57-2.68 (m, 1H), 1.99 (br. s., 2H), 1.77-1.87 (m, 2H), 1.26-1.29 (m, 3H).

21169-71-1, The synthetic route of 21169-71-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; HE, Haiying; WU, Songliang; LUO, Zhi; MOU, Jianfeng; GUO, Fengying; WANG, Chuan; LI, Guoqing; ZENG, Minggao; CHEN, Shuhui; (199 pag.)EP3456711; (2019); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

110256-15-0, 5-Cyclopropylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0267] To a stirred solution of 5-cyclopropylisoxazole-3-carboxylic acid (0.750 g, 4.90 mmol) in DCM (5 ml) was added oxalyl chloride (1.68 ml, 19.60 mmol) and 2 drops of DMF. The reaction was stirred at RT 2 hr. After complete consumption of starting material, the solvent was removed under reduced pressure to obtain 5-cyclopropylisoxazole-3-carbonyl chloride as a residue (0.6 g, crude). The material was used without further purification., 110256-15-0

110256-15-0 5-Cyclopropylisoxazole-3-carboxylic acid 1092113, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; EPIZYME, INC.; FOLEY, Megan Alene Cloonan; KUNTZ, Kevin Wayne; MILLS, James Edward John; MITCHELL, Lorna Helen; MUNCHHOF, Michael John; HARVEY, Darren Martin; (208 pag.)WO2016/40498; (2016); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42831-50-5,5-Methylisoxazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

A round bottomed flask equipped with a mechanical stiner, condenser, thermometer pocket and a stopper were added 5-Methylisoxazole-4-carboxylic acid (3.00 g, 0.02 mol) and Thionyl chloride (14.66 g, 0.12 mol) and the reaction mixture was gradually heated to 45¡À5C and stined at same temperature for 2 to 3 h. The progress of the reaction was monitored by TLC (Acid chloride was analyzed as corresponding methyl ester by quenching the samplein methanol). After the completion of reaction, the reaction mixture was concentrated under reduced pressure at 45¡À5C to afford 5-Methylisoxazole-4-carbonyl chloride as a liquid (0.59 mol).

42831-50-5, 42831-50-5 5-Methylisoxazole-4-carboxylic acid 1425240, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; BIOCON LIMITED; PALLE, Venkata, Raghavendracharyulu; BHAT, Ramakrishna, Parameshwar; KALIAPPAN, Mariappan; BABU, Jithendra, R.; SHANMUGHASAMY, Rajmahendra; (39 pag.)WO2016/203410; (2016); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

88511-37-9, 1-(Isoxazol-3-yl)ethanone is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

88511-37-9, To a -78 C solution of l-(isoxazol-3-yl)ethanone (2.18 g, 19.62 mmol) in tetrahydrofuran (58 mL) was added lithium hexamethyldisilazide (1 M in toluene, 18 mL, 18 mmol) dropwise over the course of 20 minutes. The solution was warmed to 0 C and stirred for 30 minutes, at which point diethyl oxalate (2.9 mL, 21.6 mmol) was added over the course of 5 minutes. The solution was warmed to room temperature and stirred for 45 minutes. Ethanol (58 mL), hydrazine hydrate (0.88 mL, 18 mmol), and acetic acid (5.8 mL) were sequentially added. The heterogeneous solution was heated to 70 C. After stirring for 2.25 hours at this temperature, the solvent was removed under vacuum. Water (300 mL) and dichloromethane (300 mL) were added, the layers were separated, and the aqueous layer was extracted with dichloromethane (5 x 150 mL). The organics were combined, dried over magnesium sulfate, filtered, and the solvent was removed under vacuum. Purification by silica gel chromatography (0-15% methanol in dichloromethane) and re-purification (ethyl acetate in dichloromethane) gave impure product. The resulting solid was triturated with diethyl ether to give Interraediate-3 (2.21 g, 59%) as a white solid.

As the paragraph descriping shows that 88511-37-9 is playing an increasingly important role.

Reference£º
Patent; IRONWOOD PHARMACEUTICALS, INC.; KIM, Charles; NAKAI, Takashi; MOORE, Joel; PERL, Nicholas, Robert; IM, G-yoon, Jamie; BARDEN, Timothy, Claude; IYENGAR, Rajesh, R.; ZIMMER, Daniel, P.; FRETZEN, Angelika; RENHOWE, Paul, Allan; WO2013/101830; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

36958-61-9, 5-(Bromomethyl)-3-methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Potassium hydroxide (1.588 g) was added to a solution of 6-bromo-2-methyl-1H-imidazo[4,5-b]pyridine (2 g), 5-(bromomethyl)-3-methylisoxazole (1.8 g) and TBAI (3.48 g) in THF at 60C. The mixture was stirred under a nitrogen atmosphere at 60C for 2 hours. The reaction mixture was poured into water, and extracted with ethyl acetate. The organic layer was sequentially washed with water and a saturated brine, then dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified by NH silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (0.89 g). 1H NMR (300 MHz, DMSO-d6) delta 2.18 (3H, s), 2.63 (3H, s), 5.71 (2H, s), 6.38 (1H, s), 8.40-8.42 (1H, m), 8.42-8.46 (1H, m)., 36958-61-9

36958-61-9 5-(Bromomethyl)-3-methylisoxazole 10607354, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; KAWAKITA Youichi; KOJIMA Takuto; NII Noriyuki; ITO Yoshiteru; SAKAUCHI Nobuki; BANNO Hiroshi; LIU Xin; ONO Koji; IMAMURA Keisuke; IMAMURA Shinichi; (165 pag.)EP3450436; (2019); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

108655-63-6, 3-(Trifluoromethyl)isoxazol-5-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution OF 3- (TRIFLUOROMETHYL) isoxazol-5-amine (0.08 g, 0.55 mmol) in DMF (10 ML) is added NaH 60% dispersion in mineral oil (0.02 g, 0.55 MMOL). After stirring the mixture at RT for 15 min phenyl 4-METHOXY-2- (1, 3-OXAZOL-2- yl) phenylcarbamate (0.17 g, 055 mmol) is added and the reaction mixture is heated at 50oC for 30 min. The mixture is neutralized with 0. 1M HCl, extracted with EtOAc, and the combined organic layers are dried (MGS04), filtered, and concentrated under vacuum. The residue is triturated with CH2CL2/N-HEXANES to afford Example 16 as a white solid 0.131 g (65%). HRMS (ESI) calcd for C15HLLN404F3+H 369. 0811, found 369.0803.

108655-63-6, The synthetic route of 108655-63-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/85433; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21169-71-1,Isoxazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Compounds were synthesized in solution phase using Boc-protected amino acids on 100-200mg scale. Firstly, the amino acid (1.2-1.5equiv) was activated with HBTU (1.5equiv) and DIPEA (1.5equiv) as 0.2-0.5M solution in DMF for 10min. Then the solution was added to an amino group bearing C-terminal moiety (R1R2NH) and the mixture was stirred for a minimum of 1h at room temperature. The reaction mixture was diluted with EtOAc and washed with saturated NaHCO3 (2¡Á). The organic extracts were dried over MgSO4, filtered and evaporated in vacuo. The crude product was then treated with 20% TFA in DCM and stirred for 1-2h to remove the Boc group. TFA was removed by evaporating the reaction mixture under a stream of N2. The residue was dissolved in DCM and washed with saturated NaHCO3 (2¡Á). DCM phase was dried with MgSO4, filtered and evaporated in vacuo. Subsequent N-Boc-amino acids and amines were sequentially coupled under the same conditions. Each coupling reaction was monitored by ESMS, with most reactions going to completion overnight. All final compounds were purified on rpHPLC (97% by analytical HPLC) and fully characterized by NMR and HRMS (yields between 30% and 40%).

21169-71-1, The synthetic route of 21169-71-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yau, Mei-Kwan; Liu, Ligong; Lim, Junxian; Lohman, Rink-Jan; Cotterell, Adam J.; Suen, Jacky Y.; Vesey, David A.; Reid, Robert C.; Fairlie, David P.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 3; (2016); p. 986 – 991;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

88511-37-9, 1-(Isoxazol-3-yl)ethanone is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,88511-37-9

Step 2:Pyrazole formation: Dione enolate B was diluted with ethanol and consecutively charged with HCI (e.g., 3 equiv, 1.25 M solution in ethanol) and arylhydrazine hydrate (e.g., 1.15 equiv). The reaction mixture was heated to 70 C and stirred at this temperature until cyclization was deemed complete (e.g., by LC/MS analysis, typically 30 minutes). Once complete, the reaction mixture was treated carefully with solid sodium bicarbonate (e.g., 4 equiv) and diluted with dichloromethane and water. Layers were separated, and aqueous layer was futher diluted with water before extraction with dichloromethane (3x). The combined organics were washed with brine, dried over MgS04, filtered, and concentrated in vacuo. The resulting pyrazole C was then purified by S1O2 chromatography using an appropriate gradient of EtOAc in hexanes.

The synthetic route of 88511-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IRONWOOD PHARMACEUTICALS, INC.; RENNIE, Glen Robert; PERL, Nicholas; LEE, Thomas Wai-Ho; RENHOWE, Paul Allan; NAKAI, Takashi; MERMERIAN, Ara; IM, G-Yoon Jamie; (235 pag.)WO2016/44445; (2016); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem