Tag: M.W:100-200

19788-37-5, 4-(Chloromethyl)-3,5-dimethylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Chloromethyl-3,5-dimethyl-isoxazole (1.5 eq. ) was directly added to a solution of 2-furan-2-yl-5-piperazin-1-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine (0.14 mmol; see Example 1 (a) above) and Et3N (0.3 mmol) in 3 mL of CH3CN. The resulting reaction mixture was stirred at room temp for 18 hours. It was then concentrated and purified by preparative HPLC using a mixture of aqueous CH3CN that has been buffered with 0.1 % TFA. 1H NMR (DMSO-d6) delta 7.60 (d, J = 1.0 Hz, 1 H), 7.28 (br s, 2 H), 7.22 (d, J = 3.6 Hz, 1 H), 6.68 (dd, J = 3.6 Hz, 1.0 Hz, 1 H), 3.8 (br s, 2 H), 2.2-3.2 (m, 8H), 1.6 (br s, 6H). MS: m/z: 396 [M + H] +., 19788-37-5

19788-37-5 4-(Chloromethyl)-3,5-dimethylisoxazole 88246, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; BIOGEN IDEC MA INC.; WO2004/92170; (2004); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.110256-15-0,5-Cyclopropylisoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 5-cyclopropylisoxazole-3-carboxylic acid (lOOmg, 0.653mmol) in DMF (2ml) was added HATU (370 mg, 0.980 mmol). The reaction stirred at room temperature for 30 minutes and then was cooled to 0C. l-Cyclopropyl-4- methylpyrrolidin-3 -amine (109 mg, 0.781 mmol) was added followed by DIPEA (252 mg, 1.960 mmol). The reaction stirred at ambient temperature for 2 hours. After completion of the reaction the reaction mixture was poured into 50 ml of water. The aqueous phase was extracted with ethyl acetate (3 x 25ml). The combined organic extracts were washed with brine, dried over sodium sulfate and concentrated under vacuum. The material was purified using column chromatography. The product was eluted at 2% MeOH in DCM. Appropriate fractions were combined and concentrated under vacuum to get 150 mg (83.79 %) of 5-cyclopropyl-N-(l-cyclopropyl-4- methylpyrrolidin-3-yl)isoxazole-3-carboxamide as a mixture of enantiomers and diastereomers. Cis and trans isomers were seperated out by chiral preparative HPLC using 0.1% TFA in hexanes/isopropanol as mobile phase to afford 35 mg of (¡À)-cis-5- cyclopropyl-N-(l-cyclopropyl-4-methylpyrrolidin-3-yl)isoxazole-3-carboxamide (Fraction- 1) and 49 mg of (¡À)-tra/?5-5-cyclopropyl-N-(l-cyclopropyl-4-methylpyrrolidin- 3 -yl)isoxazole-3 -carboxamide (Fraction-2) . [0196] (¡À)-cz5-5-cyclopropyl-N-(l-cyclopropyl-4-methylpyrrolidin-3-yl)isoxazole-3- carboxamide: 1H NMR (400 MHz, MeOD): delta 6.41 (s, 1H), 4.33 (bs, 1H), 3.94-3.66 (m, 3H), 3.15-3.00 (m, 2H), 2.56-2.53 (m, 1H), 2.22-2.15 (m, 1H), 1.37-1.33 (d, J = 18.4 Hz, 3H), 1.23 (d, J = 6.8 Hz, 2H), 1.00-0.99 (m, 5H); LCMS: m/z = 277.23 [M+H]+. [0197] (¡À)-tra/?5-5-cyclopropyl-N-(l-cyclopropyl-4-methylpyrrolidin-3-yl)isoxazole-3- carboxamide: 1H NMR (400 MHz, MeOD): delta 6.42 (s, 1H), 4.15 (bs, 1H), 3.77-3.66 (m, 3H), 3.52-3.37 (m, 2H), 3.04 (bs, 2H), 2.62 (bS, 1H), 2.22-2.26 (m, 1H), 1.19-1.12 (m, 2H), 1.09 (d, J = 7.2 Hz, 3H), 1.01-0.98 (m, 5H), 0.97-0.90 (m, 2H); LCMS: m/z = 276.18 [M+H]+.

110256-15-0, As the paragraph descriping shows that 110256-15-0 is playing an increasingly important role.

Reference£º
Patent; EPIZYME, INC.; FOLEY, Megan Alene Cloonan; KUNTZ, Kevin Wayne; MITCHELL, Lorna Helen; MUNCHHOF, Michael John; HARVEY, Darren Martin; (151 pag.)WO2016/40504; (2016); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4369-55-5,5-Amino-3-phenylisoxazole,as a common compound, the synthetic route is as follows.,4369-55-5

Synthesis of N-(3-Phenyl-isoxazol-5-yl)-malonamic acid ethyl ester A solution of 3-phenyl-isoxazol-5-ylamine (500 mg, 0.31 mmol) and mono-ethyl malonyl chloride (56 mg, 0.37 mmol) in dichloromethane (2 mL) was stirred at ambient temperature overnight. The mixture was diluted with water and extracted with dichloromethane. The dichloromethane layer was washed with saturated sodium bicarbonate solution, followed by brine, dried over Na2SO4, concentrated to afford 78 mg (92.85percent Yield) of N-(3-phenyl-isoxazol-5-yl)-malonamic acid ethyl ester.

4369-55-5 5-Amino-3-phenylisoxazole 261201, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; FOREST LABORATORIES HOLDINGS LIMITED; US2009/239848; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

31329-64-3, 3,5-Dimethylisoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

31329-64-3, EXAMPLE 17 Compound CQ Thionyl chloride (0.46 mL) is added to a solution of 5-cyclopentyloxy-6-methoxynicotinic acid (500 mg) and dimethylformamide (1 drop) in toluene (10 mL). The mixture is heated and stirred at reflux for 1 hour. The mixture is cooled, concentrated, and the residue dissolved in dichloromethane (5 mL). This solution is added dropwise to a solution of 4-amino-3,5-dimethylisoxazole (168 mg) and triethylamine (0.21 mL) in dichloromethane (20 mL). The resulting mixture is stirred at room temperature for 2 hours then at reflux for 1 hour. The cooled mixture is washed with water, 2 M aqueous hydrochloric acid, water, then dried (MgSO4). After concentration the yellow oily residue is triturated with a mixture of n-pentane and methyl t.butyl ether to give 5-cyclopentyloxy-N-(3,5-dimethylisoxazol-4-yl)-6-methoxynicotinamide (240 mg) as a buff solid, m.p. 139-40 C. [Elemental analysis: C, 61.3; H, 6.40; N, 12.4% calculated: C, 61.6; H, 6.39; N, 12.68%.]

31329-64-3 3,5-Dimethylisoxazol-4-amine 182040, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Aventis Pharma Limited; US6472412; (2002); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

21169-71-1, Isoxazole-5-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of an acid (2 equiv) in DMF (0.1 mL) were added a solution of an alcohol (0.013 mmol) in DMF (0.1 mL) and a solution of DMAP (2 equiv) in DMF (0.1 mL). To this resulting solution was added a suspension of EDAC (2.7 equiv) in DMF (0.1 mL). The mixture was shaken at 50 C overnight. The crude was subjected to preparative LCMS purification, giving an ester., 21169-71-1

21169-71-1 Isoxazole-5-carboxylic acid 2060599, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; LEO PHARMA A/S; LIANG, Xifu; LARSEN, Jens; NIELSEN, Simon Feldbaek; ANDERSEN, Peter; (97 pag.)WO2018/108910; (2018); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

1202769-66-1, 2-(5-Methylisoxazol-3-yl)but-3-yn-2-ol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3-Chiral separation The racemic mixture of (45-b) was separated on preparative chiral column by the method described in WO 2009/158011 to give (2R)-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol and (2S)-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol.of (2R)-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol and (2S)-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol, 1202769-66-1

The synthetic route of 1202769-66-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Genentech, Inc.; US2012/214762; (2012); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

54593-26-9,54593-26-9, 3,5-Dimethyl-4-isoxazolecarbaldehyde is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of previously synthesized N-{[4-methyl-2- (piperid in-i -yl)phenyl](5-methylfuran-2-yl)methyl}-2-(2-oxo- 2,3-dihydro-i H-indol-5-yl)acetamide Cpd.24 (75 mg, 0.16 mmol) and 3,5-dimethyl-i ,2-oxazole-4-carbaldehyde (25 mg, 0.20 mmol) in EtOH (2 mL) was added few drops ofcatalytic piperidine. The reaction mixture was heated at080 C overnight. The solvents were removed under reducedpressure. The crude material was purified by silica gelcolumn chromatography using CH2CI2/MeOH (95:5) aseluent to afford 2-{3-[(dimethyl-i 2-oxazol-4-yl)methylidene]-2-oxo-2,3-dihydro-i H-indol-5-yl}-N-{[4-methyl-2-(piperidin-i-yl)phenyl](5-methylfuran-2-yl)methyl}acetamide (80 mg, 86%) as yellow solid, mp:128C1H NMR (300 MHz, din ppm): 1.40-i .54 (m, 6H), 2.16 (s,3H), 2.20 (s, 3H), 2.22 (s, 3H), 2.24 (s, 3H), 2.50-2.60 (m,2H), 2.71-2.81 (m, 2H), 3.34 (s, i.5H), 3.44 (s, 0.5H), 5.77(d, 0.75H, J=3.OHz), 5.82 (d, 0.25H, J=2.9Hz), 5.90-5.95(m, 1H), 6.44 (d, 0.75H, J=8.3Hz), 6.49 (d, 0.25H, J=8.iHz),6.74 (d, 0.25H, J=7.8Hz), 6.78 (d, 0.75H, J=8.OHz), 6.85-6.93 (m, 2.75H), 7.11-7.13 (m, i.75H), 7.20 (s, 0.75H), 7.22(s, 0.25H), 7.41 (s, 0.25H), 7.51 (s, 0.25H), 8.68 (d, 0.75H,J=8.5Hz), 8.72 (d, 0.25H, J=8.OHz), 10.47 (s, 0.25H), 10.57(s, 0.75H); m/z: 565 [M+H]+ (calc. mass: 564).

54593-26-9 3,5-Dimethyl-4-isoxazolecarbaldehyde 289576, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; GENFIT; DELHOMEL, Jean-Francois; PERSPICACE, Enrico; MAJD, Zouher; PARROCHE, Peggy; WALCZAK, Robert; (284 pag.)WO2018/138362; (2018); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-37-5,4-(Chloromethyl)-3,5-dimethylisoxazole,as a common compound, the synthetic route is as follows.

To a solution of 2-(2,4-dimeihyiphenyl)-A’-(4-hydroxybenzyl)-2-phenylaceiamide (0.06 g,0.17 mmol) in acetonitrile (3 mL) was added cesium carbonate (0. 7 g, 0.52 mmol) and 4- (chloromethy])-3,5-dimethyfisoxazofe (0,03 g, 0.21 mmol). The resulting mixture was heated at 70 C and stirred for 2 h in a sealed-tube. After completion of the reaction, water ( 10 mL) was added, and ihe mixture was extracted with ethyl acetate (2 x 15 mL). The combined organic layers were dried over a2S04 and evaporated under vacuum to obtain crade product which was purified by preparatory TLC on silica gel to provide the title compound (50, 1 mg, 63.57%) ]H NMR (400 MHz, DMSO-d6) delta ppm 8.61-8.64 (s, 1 H), 7.26-7.30 (t, 2 H), 7.14-7.23 (m, 5 H), 5.08 is, 1 H), 4.88 (s, 2 H), 4.21-4.24 (t, 2 H), 2.38 (s, 3 H), 2.15-2.22 (i, 9 H).

19788-37-5, The synthetic route of 19788-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19635; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

2510-36-3, 3,5-Dimethylisoxasole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of lithium bis(trimethylsilyl)amide (10 g, 60 mmol, 3 eq) in toluene (60 mL) was added drop wise during 15 min to a solution of 3,5-dimethylisoxazole-4-carboxylic acid (2.82 g, 20 mmol) and methyl benzoate (2.5 mL, 1 eq) in THF (20 mL) at a temperature not exceeding 40 deg. After 1 h the reaction was quenched by the addition of a water solution of 0.1M HCl (0.3 L) leaving the water phase still basic and the phases was separated. The water phase was washed with toluene and then reduced in volume by evaporation until most of the residual organic solvents were removed. 1M HCl was added dropwise with stirring. The resulting crystals were filtered and dried in vacuum to yield the title compound. 1H NMR (400 MHz, CHLOROFORM-D) delta ppm 2.45 (s, 3H) 4.75 (s, 2H) 7.43-7.51 (m, 2H) 7.55-7.63 (m, 1H) 7.86-8.12 (m, 2H), 2510-36-3

As the paragraph descriping shows that 2510-36-3 is playing an increasingly important role.

Reference£º
Patent; Amgen Inc.; Biovitrum AB; US2008/21022; (2008); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

0.172 g (1.00 mmole) of ethyl 5-hydroxymethyl-isoxazole-3-carboxylate and 0.33 ml (1.92 mmoles) of N,N-diisopropylethylamine are dissolved in 9 ml of 1,2-dichloroethane then cooled to 0 C. 0.184 g (0.91 mmole) of p-nitrophenyl chloroformate in solution in 2 ml of 1,2-dichloromethane are added. The mixture is stirred for 20 mins at ambient temperature, then 0.230 g (0.91 mmole) of 2-(4-chlorophenoxy)-7-aza-spiro[3.5]-nonane, obtained in stage 2.2, is added. The mixture is heated at 60 C. for 15 hrs. After return to ambient temperature, a 1N aqueous solution of caustic soda is added, and the product is extracted with dichloromethane. The combined organic phases are then successively washed three times with a 1N aqueous solution of caustic soda, twice with a saturated aqueous solution of ammonium chloride and once with a saturated aqueous solution of sodium chloride, dried over sodium sulphate, filtered and evaporated to dryness. 0.447 g of the expected product are obtained in the form of a colourless oil which is used as such in the following stage., 123770-62-7

The synthetic route of 123770-62-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI; US2012/129830; (2012); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem