Category: 198470-85-8

Ren, Lei published the artcileEffect of celecoxib combined with parecoxib sodium for preemptive analgesia after lumbar fusion surgery, Safety of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Hebei Yixue (2017), 23(8), 1352-1356, database is CAplus.

Objective: To observe the effect of celecoxib combined with parecoxib sodium for preemptive analgesia in the treatment of early pain after lumbar fusion surgery. Methods: Between Nov. 2015 and June 2016, 105 patients who were planned to undergo posterior lumbar fusion were excluded from the history of peptic ulcer and coronary heart disease (35 cases of lumbar spinal stenosis, 50 cases of lumbar disk herniation, 20 cases of degenerative lumbar spondylolisthesis) were randomly divided into 3 groups with 35 persons in each group. Group A was given postoperative celecoxib + patient controlled analgesia (patient controlled analgesia, PCA) group, group B was postoperative parecoxib sodium + PCA pump group, and group C was celecoxib combined with parecoxib sodium + PCA pump for perioperative preemptive analgesia. There were no significant differences in disease distribution, gender, age, or weight among the three groups (P > 0.05). All patients underwent general anesthesia for tracheal intubation, posterior laminar decompression, intervertebral bone graft fusion, and pedicle screw internal fixation. The three groups of patients were given the corresponding medication regimen according to the grouping situation, and was administered with fentanyl for PCA after the operation. The observation indicators were the visual analog score, the dosage of analgesic pump drugs, and the incidence of adverse reactions such as nausea, vomiting, and constipation. Results: The postoperative analgesic effect of group C is better than that of group A and group B. The dosage of fentanyl in group C was less than that in group A and group B. The incidence of adverse reactions in group C was significantly lower than that in group A. There was no significant difference in the incidence of adverse reactions in group B and C. Conclusion: The preemptive analgesia of celecoxib combined with parecoxib sodium for early postoperative pain after lumbar posterior fusion surgery is better, and the analgesic effect is better than that of celecoxib or parecoxib sodium alone. It can reduce the amount of opioids, while reducing the incidence of adverse reactions.

Hebei Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Safety of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Lin, Jin-bing published the artcileEffect of parecoxib sodium on intravenous analgesic effect of dezocine after cesarean section, Computed Properties of 198470-85-8, the publication is Guangdong Yixue (2017), 38(7), 1098-1100, database is CAplus.

Objective: To observe the effect of parecoxib sodium on the analgesic effect of dezocine after cesarean section and its adverse reactions. Methods: 80 patients with ASA I-II grades combined spinal-epidural anesthesia who underwent voluntary postoperative analgesia after cesarean section were divided into parecoxib sodium group (P group) and control group (C group) according to the random number table, 40 cases in each. After the fetus was delivered, group P received i.v. injection of parecoxib sodium 40 mg, and group C received i.v. injection of the same amount of normal saline. After the operation, self-controlled i.v. analgesia with dezocine was used, and the analgesic solution was dezocine 0.5 mg /kg + normal saline to 100 mL. Adopt LCP mode of administration was used: loading dose (dezocine 5 mg) + maintenance dose 2.0 mL/h + single PCA dose 1 mL, lock-in time 15 min. The visual analog (VAS) pain scores at 2, 4, 8, 12, and 24 h after the operation of the parturient were recorded. The degree of uterine contraction pain within 24 h after the operation was recorded, and the satisfaction of the parturient鈥瞫 analgesia and overall adverse reaction rate were compared. Results: The VAS scores of the incision at 8 and 12 h in the P group were significantly lower than those in the C group (P < 0.05). The degree of postoperative uterine contraction pain in group P was significantly lower than that in group C (P < 0.05). The overall satisfaction of analgesia in group P was significantly higher than that in group C (P < 0.05). There was no significant difference in the incidence of overall adverse reactions between the two groups (P > 0.05). Conclusion: Parecoxib sodium can enhance the effect of dezocine for i.v. patient-controlled analgesia after cesarean section, reduce the degree of uterine contraction pain, and improve women鈥瞫 satisfaction without increasing adverse reactions.

Guangdong Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Computed Properties of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Chang-liang published the artcileGradient elution HPLC for related substances in parecoxib sodium for injection, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Zhongnan Yaoxue (2014), 12(3), 268-270, database is CAplus.

An HPLC method was developed to determine the relevant substances in parecoxib sodium for injection. An Agilent C₁₈ column (150 mm 脳 4.6 mm, 5 渭m) was used with gradient elution. The flow-rate was 1 mL 路 min^-1. The detection wavelength was 214 nm. Parecoxib and the adjacent impurities were effectively separated The sample solution was stable in 12 h at the room temperature The average recoveries low, middle and high concentration of valdecoxib was 100.2%, 100.3% and 99.4%. The method is accurate, reliable and reproducible, and can be used for the quality control of the preparation

Zhongnan Yaoxue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Luo, Xi published the artcileAnalgesic effect of different dosage of Flurbiprofen axetil in laparoseopic cholecystectomy in comparison with other analgesic drugs, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Pakistan Journal of Pharmaceutical Sciences (2017), 30(5), 1895-1898, database is CAplus.

Flurbiprofen axetil is a non-selective cyclooxygenase inhibitor. It can target the aggregation with lipid micro sphere as drug carrier. and exert analgesic effect in surgical incision and inflammatory site. In laparoscopic cholecystectomy comparative study on analgesic effect of parecoxib and flurbiprofen axetil is relatively less. Therefore. this paper is mainly based on the observation of patients after resting VAS score. adverse reaction time and movement. to evaluate the analgesic effect of different drug dose of flurbiprofen and parecoxib sodium. which provides reference for clin. medication. The results show that the i.v. injection of parecoxib could provide effective analgesic effect in laparoscopic cholecystectomy. Also. compared with flurbiprofen. parccoxib shows a more significant analgesic effect.

Pakistan Journal of Pharmaceutical Sciences published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhao, Ling published the artcileEfficacy of intravenous injection of parecoxib sodium combined with ropivacaine incision infiltration in postoperative analgesia of transsphenoidalsellar tumor resection, SDS of cas: 198470-85-8, the publication is Sichuan Yixue (2017), 38(4), 398-401, database is CAplus.

Objective: To observe the post-operative analgesia effect and safety of i.v. injection of parecoxib sodium combined with ropivacaine incision infiltration in transsphenoidalsellar tumor resection. Methods: 80 cases of patients undergoing elective transsphenoidalsellar tumor resection were randomly divided into 4 groups (n=20) with a prospective, randomized, controlled and double-blind method. Group A received 10 mL placebo for i.v. injection and 2 mL placebo for local incision infiltration. Group p was treated with 40 mg parecoxib sodium for i.v. injection and 2 mL placebo for local incision infiltration. Group L were given 10 mL placebo for i.v. and 2 mL 1% ropivacainefor local incision infiltration. And group PL were treated with 40 mg parecoxib sodium for i.v. injection and 2 mL 1% ropivacaine for local incision infiltration. After operation, the VAS score at 6^th hour, 12^th hour, 24^th hour, 36^th hour and 48^th hour, analgesia satisfaction of patients and the number of patients with 2% lidocaine nasal drops for rescue analgesia were recorded. Adverse reaction including skin itching, nausea, vomiting, adverse cardiovascular events and local anesthetics poisoning were observed Results: The VAS score within 24 h of group A was higher than other three groups (P<0.05). The VAS score at 6^th hour after operation of group PL was lower than that of Group P (P<0.05). The VAS score at 12^th hour and 24^th hour after operation of group PL were lower than those of Group L (P<0.05). There were no significant difference in side effect between group PL and other three groups (P>0.05). Conclusion: It is effective and safe to adopt i.v. injection of parecoxib sodium combined with ropivacaine incision infiltration in postoperative analgesia of transsphenoidalsellar tumor resection.

Sichuan Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H5F3N4, SDS of cas: 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Niu, Fu-guo published the artcileEffect of preemptive analgesia with parecoxib sodium on the inflammatory cytokine and stress in puerpera after cesarean section, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Hainan Yixueyuan Xuebao (2016), 22(19), 2322-2324, 2328, database is CAplus.

Objective: To explore the effect of preemptive analgesia (PA) with parecoxib sodium on the inflammatory cytokine and stress in puerpera after cesarean section. Methods: A total of 70 pregnant women who were admitted in our hospital from May, 2015 to May, 2016 for cesarean section were included in the study and r andomized into the observation group and the control group with 35 cases in each group. A venous channel was established. The heart rate, blood pressure, and oxygen saturation were continuously monitored by the monitor. The patients in the observation group were i.v. injected with parecoxib sodium (40mg) and normal saline (2mL), while the patients in the control group were i.v. injected with normal saline (2mL) 30min before anesthesia induction. The venous blood when entering the operation room, after operation, 4h, 8h, and 12 hafter operation was extracted The plasma IL-6, TNF-α, P substance, E, and NE levels were detected. Results: IL-6 and TNF-α level after operation in the two groups were elevated, reached the peak 4hafter operation, and were gradually reduced 8hafter operation. IL-6 and TNF-α levels at each timing point after operation in the observation group were significantly lower than those in the control group (P < 0.05). P substance after operation in the two groups was elevated, reached the peak 4hafter operation, and was gradually reduced 8 h after operation. P substance level at each timing point after operation in the observation group was significantly lower than that in the control group (P < 0.05). N and NE levels after operation in the two groups were elevated, reached the peak 4h after operation, and were reduced to the levels when entering the operation time 12 hafter operation. N and NE levels at each timing point after operation in the observation group were significantly lower than those in the control group (P < 0.05). Conclusions: PA with parecoxib sodium in application of puerpera after cesarean section can effectively reduce the stress reaction, decrease the production of inflammatory cytokines, with a favorable analgesic effect, and further reduce the occurrence of postoperative complications.

Hainan Yixueyuan Xuebao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Xiong, Qiuju published the artcileEfficacy of continuous lumbar plexus block combined with multimodal analgesia after revision hip arthroplasty, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Chongqing Yike Daxue Xuebao (2017), 42(5), 560-564, database is CAplus.

Objective: To compare the analgesic efficacy between the continuous lumbar plexus block (CLPB) combining with multimodal analgesia and patient controlled i.v. analgesia (PCIA) combining with multimodal analgesia after revision hip arthroplasty. Methods: Totally 68 patients for single side revision hip arthroplasty were equally divided into CLPB group and PCIA group. The parecoxib was used in both group 3 days before operation. The ropivacaine was used to analgesia through lumbar plexus catheterization in CLPB group, and the PCIA group with tramadol and flurbiprofen analgesia. All patients continued analgesia for 3 days. After operation, the parecoxib was used when visual analog scale (VAS) scores more than 3 scores in exercise state. The VAS scores at rest and exercise state were estimated The parecoxib dose by i.v. injection and the presses of the pump were recorded. And the complications were observed Results: The VAS pain scores of CLPB group during rest at different time points after revision hip arthroplasty were significantly lower than those of PCIA group (P<0.05). The VAS scores of CLPB during exercise at 6 h, 12 h, 24 h after revision hip arthroplasty were (2.50±0.71), (3.59±0.99), (3.67±1.01), which were significantly lower than those of (4.97±0.94) (P=0.00), (4.85±0.86) (P=0.00), (4.32±0.73) (P=0.00) in PCIA group at corresponding time points. In CLPB group, the parecoxib dose by i.v. injection and presses of the pump were fewer than that of PCIA group (0.05). And the side effects of CLPB group were fewer than those in PCIA group. Conclusion: CLPB combined with multimodal analgesia can alleviate the early pain of patients undergoing revision hip arthroplasty; the patients who received CLPB technique showed better pain relief, less complication than those who been given PCIA. Therefore, CLPB combined with multimodal analgesia should be considered a better analgesia method for patients after revision hip arthroplasty.

Chongqing Yike Daxue Xuebao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H13ClN2O, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Tao, Guanghua published the artcileApplication of dexmedetomidine combined with parecoxib sodium in pulmonary lobectomy with one-lung ventilation, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Jianyan Yixue Yu Linchuang (2016), 13(23), 3348-3351, database is CAplus.

Objective: To investigate the effect of dexmedetomidine combined with parecoxib sodium on pulmonary inflammatory response in patients undergoing pulmonary lobectomy with one-lung ventilation. Methods: Eighty patients underwent pulmonary lobectomy with one-lung ventilation were randomly divided into dexmedetomidine group (group D, n = 20), parecoxib sodium group (group P, n = 20), dexmedetomidine combined with parecoxib sodium group (D + P group, n = 20) and saline control group (N group, n = 20). The groups were treated with normal saline, dexmedetomidine, parecoxib sodium and dexmedetomidine combined with parecoxib sodium, resp. Peripheral venous blood was taken from the patients, and levels of interleukin (IL)-1β, IL-6, cyclooxygenase-2 (COX-2), reactive oxygen species (ROS) at different time points were detected by ELISA immunoassay. Radial arterial blood was taken from the patients and analyzed, and the partial pressure of blood oxygen (PaO₂), partial pressure of carbon dioxide (PaCO₂) and oxygenation index were compared. VAS pain score and analgesic dose were recorded at 12 h and 24 h after surgery. Results: The expression of inflammatory factors in D + P group was significantly lower than that in other groups, and that of the D group and P group were significantly less than that of N group (P < 0.05). The blood gas anal. showed that PaO₂ and oxygenation index in the D + P group were higher than those of the N group, while PaCO₂ is lower, and there is no statistically significant difference between the P group and D group (P > 0.05). In comparison of VAS score and 24 h tramadol dosage, the D + P group had the lowest VAS score and tramadol dosage, which were significantly lower than those of the N group (P < 0.05). Conclusion: Dexmedetomidine combined with parecoxib sodium can reduce intraoperative pulmonary inflammatory response, improve oxygenation and reduce the dose of postoperative analgesics in patients undergoing pulmonary lobectomy with one-lung ventilation.

Jianyan Yixue Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H8O3, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhang, Yan published the artcileObservation of parecoxib sodium combined with midazolam in prevention of restlessness after endoscopic surgery, Computed Properties of 198470-85-8, the publication is Zhongguo Linchuang Yanjiu (2014), 27(3), 316-318, database is CAplus.

Objective To observe the effect of parecoxib sodium combined with small dose of midazolam in prevention of restlessness after endoscopic surgery. Random 90 patients receiving general anesthesia for elective endoscopic sinus surgery were divided into P, PM, C groups with 30 cases in each group, and before the end of 30 min of endoscopic sinus surgery, P group was given i.v. parecoxib sodium 40 mg, PM group was given i.v. parecoxib sodium 40 mg + midazolam 0.02 mg/kg, and group C was given i.v. injection of saline. The breathing recovery time, eye opening time, extubation time; and MAP and HR values at extubation (T1) and 5 min (T2) after extubation and 10 min (T3) after extubation were detected, and the restlessness score (RS), Ramasay sedation score (RSS), and visual analog scale (VAS) at postoperative 6h, 12h and 24h were recorded. Results The MAP and HR values at T1-T3 were superior in PM group (P<0.05); RS, RSS and VAS values at different time points in PM group were lower than P group and C group (P<0.05); the breathing recovery time, eye opening time and extubation time had no difference among the three groups (P>0.05). There were 14 cases of nausea and 11 cases of vomiting in C group; 12 cases of nausea and 9 cases of vomiting in P group; 8 cases of nausea and six cases of vomiting in PM group; nausea and vomiting was similar among the three groups (P>0.05). Conclusion Parecoxib combined with low-dose midazolam anesthesia may be effective in preventing endoscopic surgery restlessness, and can be safely used for analgesia after endoscopic sinus surgery.

Zhongguo Linchuang Yanjiu published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C6H17NO3Si, Computed Properties of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Xiuze published the artcileParecoxib sodium pretreatment reduces myoclonus after etomidate: a prospective, double-blind, randomized clinical trial, Category: isoxazole, the publication is International Journal of Clinical Pharmacology and Therapeutics (2017), 55(7), 601-605, database is CAplus and MEDLINE.

Objective: Myoclonus induced by etomidate during induction of general anesthesia is a common phenomenon. This prospective, randomized, saline-controlled clin. study was performed to evaluate the effect of parecoxib sodium pretreatment on the incidence and severity of etomidate induced myoclonus. Methods: 60 patients, American Society of Anesthesiologists (ASA) phys. status I or II, aged 20 to 60 years, who were scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia, were allocated randomly into one of two groups to receive parecoxib sodium 40 mg i.v. (group P, n = 30) or the same volume of saline (group S, n = 30) 30 min before administration of etomidate (0.3 mg/kg). Myoclonus was assessed on a scale of 0 – 3. Postoperative side effects were recorded. Results: The two groups were comparable with regard to baseline characteristics. The incidence of myoclonus was significantly lower in the parecoxib sodium group (11/30; 37%) than in the saline group (21/30; 70%) (p < 0.05). The severity of myoclonic movements was also significantly reduced by parecoxib sodium (p < 0.05). There were no significant differences between the two groups with respect to postoperative side effects. Conclusions: Pretreatment with i.v. injection of parecoxib sodium 40 mg significantly reduced the incidence and severity of etomidate- induced myoclonus without significant side effects.

International Journal of Clinical Pharmacology and Therapeutics published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem