Month: November 2022

Shi, Junchao published the artcileThe PERK/PKR-eIF2α pathway negatively regulates porcine hemagglutinating encephalomyelitis virus replication by attenuating global protein translation and facilitating stress granule formation, Application In Synthesis of 2323027-38-7, the publication is Journal of Virology (2022), 96(1), e01695, database is CAplus.

The replication of coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERSCoV), and the recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is closely associated with the endoplasmic reticulum (ER) of infected cells. The unfolded protein response (UPR), which is mediated by ER stress (ERS), is a typical outcome in coronavirus-infected cells and is closely associated with the characteristics of coronaviruses. However, the interaction between virus-induced ERS and coronavirus replication is poorly understood. Here, we demonstrate that infection with the betacoronavirus porcine hemagglutinating encephalomyelitis virus (PHEV) induced ERS and triggered all three branches of the UPR signaling pathway both in vitro and in vivo. In addition, ERS suppressed PHEV replication in mouse neuro-2a (N2a) cells primarily by activating the protein kinase R-like ER kinase (PERK)- eukaryotic initiation factor 2α (eIF2α) axis of the UPR. Moreover, another eIF2α phosphorylation kinase, interferon (IFN)-induced double-stranded RNA-dependent protein kinase (PKR), was also activated and acted cooperatively with PERK to decrease PHEV replication. Furthermore, we demonstrate that the PERK/PKR-eIF2α pathways neg. regulated PHEV replication by attenuating global protein translation. Phosphorylated eIF2α also promoted the formation of stress granules (SGs), which in turn repressed PHEV replication. In summary, our study presents a vital aspect of the host innate response to invading pathogens and reveals attractive host targets (e.g., PERK, PKR, and eIF2α) for antiviral drugs. IMPORTANCE Coronavirus diseases are caused by different coronaviruses of importance in humans and animals, and specific treatments are extremely limited. ERS, which can activate the UPR to modulate viral replication and the host innate response, is a frequent occurrence in coronavirus-infected cells. PHEV, a neurotropic betacoronavirus, causes nerve cell damage, which accounts for the high mortality rates in suckling piglets. However, it remains incompletely understood whether the highly developed ER in nerve cells plays an antiviral role in ERS and how ERS regulates viral proliferation. In this study, we found that PHEV infection induced ERS and activated the UPR both in vitro and in vivo and that the activated PERK/PKR-eIF2α axis inhibited PHEV replication through attenuating global protein translation and promoting SG formation. A better understanding of coronavirus-induced ERS and UPR activation may reveal the pathogenic mechanism of coronavirus and facilitate the development of new treatment strategies for these diseases.

Journal of Virology published new progress about 2323027-38-7. 2323027-38-7 belongs to isoxazole, auxiliary class Metabolic Enzyme,ATF/CREB proteins, name is N-(1-(2,4-Bis(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-5-(furan-2-yl)isoxazole-3-carboxamide, and the molecular formula is C11H15NO2, Application In Synthesis of 2323027-38-7.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yang, Ting published the artcileEffects of rTMS combined with rPMS on stroke patients with arm paralysis after contralateral seventh cervical nerve transfer: a case-series, Computed Properties of 198470-85-8, the publication is International Journal of Neuroscience, database is CAplus and MEDLINE.

We conducted this study to evaluate the effect of rTMS combined with rPMS on stroke patients with arm paralysis after CSCNTS. A case-series of four stroke patients with arm paralysis, ages ranging from 39 to 51 years, that underwent CSCNTS was conducted. Patients were treated with 10 HZ rTMS on the contralesional primary motor cortex combined with 20 HZ rPMS on groups of elbow and wrist muscles for 15 days. The muscle tone of elbow flexor muscle (EFM), elbow extensor muscle (EEM), wrist flexor muscle (WFM) and flexor digitorum (FD) reduced immediately after operation followed by increasing gradually. After rehabilitation, the muscle tone of EEM and EFM reduced by 14% and 11%, resp. There was a 13% and 45% change ratio in WFM and FD. The numeric rating scale (mean = 5.75 ± 1.71) was significantly lower (mean = 3.25 ± 1.90, t = 8.66, p = .00). Grip and pinch strength (mean = 23.65 ± 4.91; mean = 4.9 ± 0.59) were significantly higher (mean = 34.63 ± 5.23, t = -61.07, p = .00; mean = 7.1 ± 0.73, t = -13.91, p = .00). The rehabilitation of stroke patients with arm paralysis after CSCNTS is a long, complicated process which includes great change of neuropathic pain, muscle tone, and muscle strength. In order to enhance the neural connection between the contralesional hemisphere and the hemiplegic limb, alleviate postoperative complications, as well as accelerate the rehabilitation process, we can consider to use rTMS combined with rPMS.

International Journal of Neuroscience published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C25H29N9O3, Computed Properties of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yang, Lihua published the artcileInfluence of parecoxib sodium on stress, inflammatory response and postoperative analgesia in patients undergoing radical resection of esophageal cancer, COA of Formula: C19H17N2NaO4S, the publication is Zhonghua Shiyan Waike Zazhi (2015), 32(9), 2302-2303, database is CAplus.

Influence of parecoxib sodium on plasma Cor, β-EP, PGE2, TNF-α and IL-6 in patients undergoing radical resection of esophageal cancer was observed Sixty cases with radical resection of esophageal cancer were chosen and randomly divided into parecoxib sodium group (P) and control group (C). Plasma Cor, β-EP, PGE2, TNF-α and IL-6 were determined before induction (T1), 2 h during surgery(T2), end of surgery (T3), 12 h (T4), 24 h (T5), 48 h (T6) after surgery. Indexes in P group were significantly lower than those in C group. Parecoxib sodium could alleviate stress response, weaken peripheral and central sensitization and alleviate inflammatory response.

Zhonghua Shiyan Waike Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C9H8BNO2, COA of Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Chen, Wei published the artcileEffects of parecoxib sodium preemptive analgesia on postoperative inflammatory cytokines and stress responses in elderly patients undergoing total hip replacement, COA of Formula: C19H17N2NaO4S, the publication is Huaxi Yixue (2015), 30(6), 1067-1070, database is CAplus.

Objective: To investigate whether parecoxib sodium preemptive analgesia reduces inflammatory cytokines and stress hormones production in elderly patients after total hip replacement. Methods: Sixty patients with American Society of Anesthesiologists Classification I-II undergoing total hip replacement for femoral neck fracture or aseptic necrosis of the femoral head, aged between 60 and 90 years with a body weight more than 50 kg, were randomly divided into preemptive analgesia group (group P, n = 30) and control group (group C, n = 30). The patients in group P received parecoxib sodium 40 mg i.v. 30 min before skin incision, and another 20 mg 8 h after the first administration. All the patients in the two groups received the administration of patient-controlled analgesia sufentanyl. We recorded blood levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), cortisol (COR), adrenaline (AD) and noradrenaline (NAD) 30 min before skin incision, and 1 h, 6 h, 12 h and 24 h postoperatively. Results: The blood levels of IL-6, TNF-α, COR, AD and NAD in group P at 1 h, 6 h, 12 h or 24 h postoperatively were significantly lower than those in group C (P<0.05). Conclusion: Parecoxib sodium preemptive analgesia reduces postoperative inflammatory cytokines and stress hormones production in elderly patients undergoing total hip replacement.

Huaxi Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, COA of Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Hai-ying published the artcileEffect of ulinastatin and parecoxib sodium on intrapulmonary shunt fraction during one lung ventilation, SDS of cas: 198470-85-8, the publication is Shiyong Yaowu Yu Linchuang (2017), 20(1), 30-34, database is CAplus.

Objective: To explore the effect of ulinastatin and parecoxib sodium on intrapulmonary shunt during one lung ventilation. Methods: One hundred patients receiving one lung ventilation treatment for esophageal cancer from Apr. 2014 to Apr. 2015 were involved as the observation objects. According to the patient preference, patients were divided into group A (n=50) and group B (n=50). The same induction of anesthesia and anesthesia drugs were given to them to maintain the same depth of anesthesia. Half an hour before anesthesia, 40 mg parecoxib sodium was given to group A, and 50 U UTI was given to group B. The mean airway pressure, heart rate, mean arterial pressure, oxygen saturation, arterial carbon dioxide partial pressure, pulmonary shunt fraction, interleukin (IL)-6, IL-8 Junior necrosis factor α and C-protein expression were compared at the following time points: after induction of anesthesia (S₁ period), 0.5 h after one-Lung ventilation (S₂ period), 1 h after one lung ventilation (S₃ period) and 0.5 h after restoring lung ventilation (S₄ period). Results: The mean arterial pressure of group A (77.9±11.5) was higher than that of group B (73.6±9.1) at the period of S₄, the difference was statistically significant (P<0.05). The arterial carbon dioxide tension of group A (41.4±3.8, 41.8±3.4, 41.7±2.8) was higher than that of group B (42.7±2.1, 42.7±2.1, 44.8±3.7) at the period of S₂, S₃ and S₄, the difference were statistically significant (P<0.05). The pulmonary shunt fraction of group A was lower than that of group B on the period of S₂ and S₃. The pulmonary shunt fractions of the two groups on the period of S₂ and S₃ were higher than those on the period of S₄. Conclusion: Parecoxib sodium and ulinastatin have protective effect on one lung ventilation, but parecoxib sodium reduces intrapulmonary shunt fraction more significantly which can avoid the damage to the lung tissue to some extent.

Shiyong Yaowu Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, SDS of cas: 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wang, Afang published the artcileRetrospective analysis on the inhibiting effect of parecoxib sodium on the inflammatory factors and stress response in patients after hip and knee replacement surgery, Formula: C19H17N2NaO4S, the publication is Yaowu Liuxingbingxue Zazhi (2016), 25(3), 146-149, database is CAplus.

Objective: To evaluate the stress reaction and inflammatory factor inhibition effect of parecoxib sodium continuous pumped after hip and knee arthroplasty, and provide a reference for the orthopaedic perioperative analgesic solution Methods: 52 cases of total hip, semi hip and knee joint surface replacement patientsâ€?clin. data were retrospectively analyzed, which divided into observation group and control group according to analgesic method, 26 cases in each group. The control group received bupivacaine for patient controlled epidural analgesia therapy after operation, patients in the observation group combined with parecoxib sodium i.v. injection pumped, 5 mg per h. The level of pain relief in different time points were observed The levels of plasma inflammatory factor, cortisol (Cor), and adrenocorticotropic hormone (Glu) were compared in the two groups. Results: The VAS score of observation group was lower than that of the control group in every time points (P<0.05). The 0 and I pain levels of IL-6 and IL-1β in the observation group were significantly higher than those in the control group (P>0.05). The levels of IL-6 and IL-1β were significantly different between two groups (Glu), and the levels of Cor and Glu were significantly lower in two groups (P<0.05). The index level of observation group were significantly lower than the control group (P<0.05). Conclusion: Parecoxib sodium continuous pumped could alleviate the pain of hip and knee replacement in patients with postoperative, reduce the levels of inflammatory factors and stress level, it was worth clin. promotion.

Yaowu Liuxingbingxue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H11BO2, Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Luo, Si-jia published the artcileEffect of oxycodone combined with parecoxib sodium on pain relief after laparoscopic cholecystectomy, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Zhongguo Xiandai Putong Waike Jinzhan (2017), 20(10), 814-815, 818, database is CAplus.

To explore the safety of oxycodone combined with parecoxib sodium in laparoscopic cholecystectomy. According to the random number table method, 102 patients who were to undergo laparoscopic cholecystectomy were divided into a control group and an observation group, with 51 cases in each group. The control group was anesthetized with morphine combined with parecoxib sodium. The observation group was anesthetized with oxycodone combined with parecoxib sodium. The pain conditions of the two groups of patients were evaluated at 3, 12, 24, and 48 h after the operation, and the number of PCA compressions and the addnl. analgesics in the two groups within 48 h after the operation were recorded. At 3, 12, 24, and 48 h after surgery, the difference in pain scores during resting and coughing between the two groups was statistically significant (P < 0.05). The number of effective PCA compressions and the addnl. rate of analgesic drugs in the observation group within 48 h after surgery were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions in the observation group was 11.8%, which was significantly lower than the 37.3% in the control group (P < 0.05). During laparoscopic cholecystectomy, the use of oxycodone combined with parecoxib sodium anesthesia can not only achieve better anesthesia and analgesia, but also reduce the occurrence of adverse reactions, thereby ensuring the safety of patients.

Zhongguo Xiandai Putong Waike Jinzhan published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Treitler, Daniel S. published the artcileDevelopment and Demonstration of a Safer Protocol for the Synthesis of 5-Aryltetrazoles from Aryl Nitriles, Related Products of isoxazole, the publication is Organic Process Research & Development (2017), 21(3), 460-467, database is CAplus.

The search for a faster, safer protocol for the direct synthesis of 5-aryltetrazoles from aryl nitriles in the presence of sodium azide and an amine hydrochloride salt led to the discovery of a buffered system comprised of BnNH₂, BnNH₂·HCl, and NaN₃. After optimization of reaction conditions and a thorough study of reaction safety, the procedure was demonstrated for the synthesis of several hundred grams of 4-chloro-2-(2H-tetrazol-5-yl)phenol. The generality of the developed reaction conditions was established by a small-scale reactivity screen using 16 addnl. aryl and heteroaryl nitrile substrates.

Organic Process Research & Development published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H16O2, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Martinez-Pardo, Pablo published the artcileEnantioselective Synthesis of Functionalized Diazaspirocycles from 4-Benzylideneisoxazol-5(4H)-one Derivatives and Isocyanoacetate Esters, Recommanded Product: 3-Phenylisoxazol-5(2H)-one, the publication is Advanced Synthesis & Catalysis (2020), 362(17), 3564-3569, database is CAplus.

Enantioenriched spirocyclic compounds bearing three contiguous stereocenters and high functionalization were obtained through a formal [3+2] cycloaddition reaction catalyzed by a cooperative system. The spiro compounds were synthesized from 4-arylideneisoxazol-5-ones and isocyanoacetate esters using a bifunctional squaramide/Bronsted base organocatalyst derived from a Cinchona alkaloid and silver oxide as Lewis acid. This method afforded two out of the four possible diastereomers with good yields and high enantiomeric excess for both diastereomers.

Advanced Synthesis & Catalysis published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Recommanded Product: 3-Phenylisoxazol-5(2H)-one.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Sutariya, Tushar R. published the artcileA domino synthetic approach for new, angular pyrazol- and isoxazol-heterocycles using [DBU][Ac] as an effective reaction medium, Quality Control of 1076-59-1, the publication is RSC Advances (2015), 5(30), 23519-23529, database is CAplus.

The synthesis of pyrazole and isoxazole based heterocycles, e.g., I and II (R = H, Cl), via domino Knoevenagel-hetero-Diels-Alder (DKHDA) reaction of O-alkenylated acetophenones with active methylene pyrazolones and 3-phenyl-1,2-oxazol-5-one, resp., in an ionic liquid [DBU][Ac], effectively at 130 °C were described. The DKHDA reaction of O-alkynylated acetophenones is also feasible with 3-phenyl-1,2-oxazol-5-one but in the presence of ZnO as catalyst because it contains the unactivated dienophile moiety. The heterosteroid-mimicking structure II (R = H, Cl) thus achieved may have different bioprofiles than the aldehyde-derived one. The use of recyclable ionic liquid in place of organic solvents in the present method offers both ecol. and environmental benefits. The stereochem. of synthesized compounds was confirmed by the single crystal X-ray diffraction data.

RSC Advances published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H11BO4, Quality Control of 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem