Month: November 2022

Lakshmi, Neelakandan Vidhya’s team published research in Tetrahedron Letters in 52 | CAS: 1076-59-1

Tetrahedron Letters published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, HPLC of Formula: 1076-59-1.

Lakshmi, Neelakandan Vidhya published the artcileUnusual mechanistic pathway for the synthesis of novel spiro-oxindoles via 3-phenyl-5-isoxazolone ring cleavage by secondary amino acids, HPLC of Formula: 1076-59-1, the publication is Tetrahedron Letters (2011), 52(27), 3437-3442, database is CAplus.

A new approach to synthesize a series of spiro-oxindole derivatives via a multicomponent reaction of isatin, 3-phenyl-5-isoxazolone, and sarcosine or L-proline which play a dual role of base and nucleophile in methanol under reflux condition is reported. Also spiroindan-1,3-diones were synthesized from ninhydrin and 3-phenyl-5-isoxazolone. The methodol. affords high yields of products in a short reaction time.

Tetrahedron Letters published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, HPLC of Formula: 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Levinson, F. S.’s team published research in Russian Journal of General Chemistry in 75 | CAS: 874-36-2

Russian Journal of General Chemistry published new progress about 874-36-2. 874-36-2 belongs to isoxazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[c][1,2,5]oxadiazol-5-amine, and the molecular formula is C6H5N3O, Product Details of C6H5N3O.

Levinson, F. S. published the artcileEvaluation of the Effect of the Furazane Fragment on the NH Acidity of 4- and 5-Picrylaminobenzofurazanes in DMF and DMSO, Product Details of C6H5N3O, the publication is Russian Journal of General Chemistry (2005), 75(6), 933-935, database is CAplus.

The products of the reactions of picryl chloride with isomeric aminobenzofurazans in DMF and DMSO were studied by nonaqueous potentiometric titration The effect of the position of the furazan fragment in 4- and 5-picrylaminobenzofurazans on the NH acidity is considered. The electron-acceptor properties of the furazan fragment were evaluated via inclusion of the resulting data into the pK a-σ correlation for 2,4,6-trinitrodiphenylamines. On this basis, conventional Hammett σ constants were calculated for the furazan fragment located in the immediate vicinity of the N-H center and one position distant from it.

Russian Journal of General Chemistry published new progress about 874-36-2. 874-36-2 belongs to isoxazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[c][1,2,5]oxadiazol-5-amine, and the molecular formula is C6H5N3O, Product Details of C6H5N3O.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Rostovskii, Nikolai V.’s team published research in Synthesis in 49 | CAS: 1076-59-1

Synthesis published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Name: 3-Phenylisoxazol-5(2H)-one.

Rostovskii, Nikolai V. published the artcileMetal-Catalyzed Isomerization of 5-Heteroatom-Substituted Isoxazoles as a New Route to 2-Halo-2H-azirines, Name: 3-Phenylisoxazol-5(2H)-one, the publication is Synthesis (2017), 49(19), 4478-4488, database is CAplus.

A convenient gram-scale method for the preparation of 2-halo-2H-azirine-2-carboxylic acid esters, thioesters and amides via metal-catalyzed isomerization of 5-heteroatom-substituted 4-haloisoxazoles was developed. The formation of the esters and amides was efficiently catalyzed by Rh2(Piv)4, while FeCl2·4H2O was the catalyst of choice for the synthesis of the thioesters. In addition, rhodium catalysis was successfully applied in the synthesis of azirine-2-carboxylates from non-halogenated 5-alkoxyisoxazoles.

Synthesis published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Name: 3-Phenylisoxazol-5(2H)-one.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Qian, Yong’s team published research in Angewandte Chemie, International Edition in 2016 | CAS: 7064-33-7

Angewandte Chemie, International Edition published new progress about Galectin-1 Role: ANT (Analyte), ANST (Analytical Study). 7064-33-7 belongs to class isoxazole, name is 5-(3-Bromophenyl)isoxazole, and the molecular formula is C9H6BrNO, Application In Synthesis of 7064-33-7.

Qian, Yong published the artcileActivity-Based Proteome Profiling Probes Based on Woodward’s Reagent K with Distinct Target Selectivity, Application In Synthesis of 7064-33-7, the main research area is protein profiling Woodward reagent K derivative; activity-based probes; fluorescent imaging; protein labeling; proteomics.

Woodward’s reagent K (WRK) is a reactive heterocyclic compound that has been employed in protein chem. to covalently and unspecifically label proteins at nucleophilic amino acids, notably at histidine and cysteine. The authors have developed a panel of WRK-derived activity-based probes and show that surprisingly and unexpectedly, these probes are fairly selective for a few proteins in the human proteome. The WRK-derived probes show unique reactivity towards the catalytic N-terminal proline in the macrophage migration inhibitory factor (MIF) and can be used to label and, if equipped with a fluorophore, to image MIF activities in living cells.

Angewandte Chemie, International Edition published new progress about Galectin-1 Role: ANT (Analyte), ANST (Analytical Study). 7064-33-7 belongs to class isoxazole, name is 5-(3-Bromophenyl)isoxazole, and the molecular formula is C9H6BrNO, Application In Synthesis of 7064-33-7.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Debbarma, Suvankar’s team published research in Organic Letters in 2019-02-01 | CAS: 7064-33-7

Organic Letters published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7064-33-7 belongs to class isoxazole, name is 5-(3-Bromophenyl)isoxazole, and the molecular formula is C9H6BrNO, Application In Synthesis of 7064-33-7.

Debbarma, Suvankar published the artcileHarnessing Stereospecific Z-Enamides through Silver-Free Cp*Rh(III) Catalysis by Using Isoxazoles as Masked Electrophiles, Application In Synthesis of 7064-33-7, the main research area is stereospecific enamide preparation rhodium catalyzed carbon hydrogen functionalization; salicylaldehyde isoxazole reaction masked electrophile.

The stereospecific synthesis of Z-enamides is described in this paper. For the first time, isoxazoles have been employed as electrophiles in C-H functionalization to afford thermodynamically less stable Z-enamides utilizing salicylaldehydes in an atom- and step-economic fashion. The stereochem. of enamides might originate from the relative disposition of atoms present in isoxazole and the intramol. hydrogen bonding. The reaction showed excellent scope as several structurally and electronically diverse salicylaldehydes and isoxazoles reacted efficiently.

Organic Letters published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7064-33-7 belongs to class isoxazole, name is 5-(3-Bromophenyl)isoxazole, and the molecular formula is C9H6BrNO, Application In Synthesis of 7064-33-7.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem

Zhang, Yicheng’s team published research in Tetrahedron Letters in 2018-05-30 | CAS: 7064-33-7

Tetrahedron Letters published new progress about Amines, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl). 7064-33-7 belongs to class isoxazole, name is 5-(3-Bromophenyl)isoxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.

Zhang, Yicheng published the artcileA novel synthesis of 5-substituted isoxazoles from propargylic amines and N-hydroxyphthalimide, Product Details of C9H6BrNO, the main research area is arylisoxazole chemoselective preparation; oxidative cyclocondensation methyl phenyl arylpropargylamine iodobenzene acetate hydroxyphthalimide.

5-Arylisoxazoles were prepared in 62-88% yields by oxidative cyclocondensation of N-hydroxyphthalimide with N-methyl-N-Ph arylpropargylamines RCCCH2NMePh (R = Ph, 4-MeC6H4, 4-EtC6H4, 4-i-PrC6H4, 4-t-BuC6H4, 4-BuC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-MeCOC6H4, 4-MeO2CC6H4, 4-EtO2CC6H4, 3-MeC6H4, 2-MeC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 3-FC6H4, 3-ClC6H4, 3-BrC6H4, 4-pyridinyl, 3,5-Me2C6H3, 3,4-Me2C6H3, 3,4-Cl2C6H3) mediated by PhI(OAc)2 without added metallic reagents in Et acetate at ambient temperature

Tetrahedron Letters published new progress about Amines, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl). 7064-33-7 belongs to class isoxazole, name is 5-(3-Bromophenyl)isoxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem