Category: 62348-13-4

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, Example 189-329 The general method described in Examples 74-113 was used to treat 9,10, 11,12- tetrahydro-8H-[1, 4] diazepino [l’, 2′ : 1,2] imidazo [4,5-c] quinolin-6-amine hydrochloride (32.5 mg, 0.100 mmol) with N, N diisopropylethylamine (0.0525 mL, 0.30 mmol) and the reagent (0.108 mmol) indicated in the table below. The compounds were purified by prep HPLC using the method described above. The table below shows the acid chloride, sulfonyl chloride, isocyanate, carbamoyl chloride, or sulfamoyl chloride used for each example, the structure of the resulting compound, and the observed accurate mass for the isolated trifluoroacetate salt.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/66172; (2005); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,62348-13-4

To a solution of CH3ONHCH3.HC1 (780 mg) and acid chloride (1 g) in CH2C12 at 0 C. was added dry pyridine (1.35 ml) to afford a heterogenous mixture The solution was warmed to room temperature and stirred overnight. 1 M HC1 was added to the reaction and the organic layer was separated, washed with brine, dried with Na2SO4, filtered, and concentrated in vacuo to give 1 g of product (85%).

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Schering Corporation and Pharmacopeia, Inc.; US2004/147559; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, General procedure: Sequentially, acid chloride (1.5 equiv) including furan-2-carbonylchloride, m-fluorobenzoylchloride, p-fluorobenzoylchloride, isoxazole-5-carbonyl chloride, adamantane-1-carbonylchloride, or naphthalene-1-sulfonylchloride (1.5 equiv) and quinoline-8-sulfonyl chloride (1.5 equiv), was added to the resulting solutionin the presence of NEt3 (3.0 equiv) and stirredat reflux for 4 h. When the sequentialone-pot multicomponent synthesis reaction was completed, the reactionmixture was added to saturate sodium bicarbonate (15 mL) and extracted withdichloromethane (15 mL ¡Á 2). Thecombined organic layer was washed saturated aqueous NaHCO3 (15 mL),dried over MgSO4, filtered, and concentrated under reduced pressure.The residue solution was purified by column chromatography on silica gel togive the corresponding N,O-disubstitutedglycolamides 5a-f, 7-11, 12a-e, and 13a-b in 66-84 % yields.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Article; Lu, Shi-Han; Yen, Wan-Ping; Tsai, Henry J.; Chen, Chien-Shu; Wong, Fung Fuh; Tetrahedron; vol. 71; 38; (2015); p. 6749 – 6758;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

Compound 6 (14.21g, 30.39mmol) was added to absolute ethanol (150 mL), followed by gradual addition of isoxazol-5-carboxylic acid chloride (35mmol), stirring the reaction was warmed to reflux.After about 8 hours, the reaction was completed and TLC was used to monitor the end of the reaction.After the reactionsolution was allowed to stand for cooling, suction filtration, and the filter cake was washed with a small amount of anhydrous ethanol to obtain a white solid product N-(((4-(diphenyl[b,d]thiophen-3-yl)-7-) Oxy-2,2-dimethylpyridin-3-yl)methyl)sulfonyl)isoxazole-5-carboxamide, 15.73 g,yield 92%.

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zeng Qingqiang; (12 pag.)CN108586445; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

62348-13-4, General procedure: A solution of the corresponding acyl chloride 1-10 (9.18 mmol) in chloroform (25 mL) was slowly added dropwise to a stirred solution of compounds a-c (4.59 mmol) in dry chloroform (40 mL) and pyridine (5 mL). The mixture was stirred for 48 h at room temperature. Solvents were removed under vacuum by rotatory evaporation and the residue was treated with water (100 mL) and purified.

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ibanez, Elena; Plano, Daniel; Font, Maria; Calvo, Alfonso; Prior, Celia; Palop, Juan Antonio; Sanmartin, Carmen; European Journal of Medicinal Chemistry; vol. 46; 1; (2011); p. 265 – 274;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.,62348-13-4

Compound 6 (11.8g, 28.06mmol) was added to absolute ethanol (150 mL), followed by gradual addition of isoxazole-5-carbonyl chloride (10.2g, 77.55mmol), The reaction was heated to reflux with stirring. After about 8 hours, the reaction was completed and TLC was used to monitor the end of the reaction.point. After the reaction solution was allowed to stand for cooling, suction filtration, and the filter cake was washed with a small amount of anhydrous ethanol to obtain a white solid product N-(((4-(2,3-dihydro-[1,4]dioxacyclohexane) Alkeno[2,3-b]pyridin-7-yl)-7-methoxy-2,2-dimethylpyridin-3-yl)methyl)sulfonyl)isoxazole-5-carboxamide, 13.8 g, yield 95.6%.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; Zeng Qingqiang; (11 pag.)CN108570056; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

62348-13-4, To a solution of CH3ONHCH3.HCl (780 mg) and acid chloride (19) in CH2Cl2 at 0 C. was added dry pyridine (1.35 ml) to afford a heterogenous mixture The solution was warmed to room temperature and stirred overnight. 1 M HCl was added to the reaction and the organic layer was separated, washed with brine, dried with Na2SO4, filtered, and concentrated in vacuo to give 1 g of product (85%).

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; Schering Corporation; US2004/106794; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, Gemaess der allgemeinen Arbeitsvorschrift F werden 50 mg (0.14 mmol) [7- (3-AMINO-] [PHENYL)-N [ (3R)-1-AZABICYCLO] [2.2. 2] [OCT-3-YL]-1-BENZOFURAN-2-CARBOXAMID] (Beispiel 114) und [36.] 4 mg (0.28 mmol) [5-ISOXAZOLCARBONSaeURECHLORID] miteinander umgesetzt. Es werden 39.6 mg (53.3 % d. Th. ) der Titelverbindung erhalten. HPLC (Methode [1)] : Rt=4. 18 min. MS (ESIpos) : m/z = 457 (M+H) + (freie Base).

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; BAYER HEALTHCARE AG; WO2003/104227; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, To a solution of the above material (0.300 g, 0.708 mmol) in CH2Cl2 (3 mL), isoxazole-5-carbonyl chloride (0.1024 g, 0.78 mmol) and triethylamine (0.13 mL, 0.92 mmol) were added. The resulting solution was stirred at room temperature overnight, and partitioned between CH2Cl2 and water. The organic extract was washed with brine, dried over Na2SO4, filtered and concentrated. The residue was subjected to silica gel chromatography eluted with 10-40% ethyl acetate in hexanes to provide the title compound that gave a proton NMR spectrum consistent with theory and a mass ion (ES+) of 519.3 for M+H+(35Cl): 1H NMR (300 MHz, MeOH-d4) delta 8.59 (s, 1H), 7.83 (d, J=5.6 Hz, 1H), 7.60 (q, J=8.0 Hz, 1H), 7.31-7.23 (m, 4H), 7.11 (s, 1H), 7.02 (d, J=8.1 Hz, 1 H), 6.69 (d, J=5.6 Hz, 1 H), 5.23 (q, J=6.8 Hz, 1H), 4.86 (s, 3H), 1.48 (d, J=7.0 Hz, 3H).

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Kuduk, Scott D.; Bock, Mark G.; Feng, Dong-Mei; Wai, Jenny Miu-Chun; US2004/29920; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, To a solution of CH30NHCH3. HCI (780mg) and acid chloride (1g) in CH2CI2 at 0 C was added dry pyridine (1. 35ml) to afford a heterogenous mixture The solution was warmed to room temperature and stirred overnight. 1 M HCI was added to the reaction and the organic layer was separated, washed with brine, dried with Na2SO4, filtered, and concentrated in vacuo to give 1 g of product (85%).

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/68460; (2005); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem