Category: 62348-13-4

62348-13-4,62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 9f (100 mg, 0.32 mmol) in DMA (3 mL) was added 3-fluorobenzoyl chloride (43 muL, 0.36 mmol), and the mixture was stirred at room temperature overnight. The mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water and brine, dried over MgSO4, and filtered. The filtrate was concentrated in vacuo, and the residue was purified by basic silica gel column chromatography (n-hexane/EtOAc 100:0 to 0:100) to give 10f (56 mg, 40%) as a white solid.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Article; Miyamoto, Naoki; Sakai, Nozomu; Hirayama, Takaharu; Miwa, Kazuhiro; Oguro, Yuya; Oki, Hideyuki; Okada, Kengo; Takagi, Terufumi; Iwata, Hidehisa; Awazu, Yoshiko; Yamasaki, Seiji; Takeuchi, Toshiyuki; Miki, Hiroshi; Hori, Akira; Imamura, Shinichi; Bioorganic and Medicinal Chemistry; vol. 21; 8; (2013); p. 2333 – 2345;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, EXAMPLE 2 6.52 parts of 2-methylpyridine were added to a stirred mixture of 15.7 parts of 7-chloro-5-nitro-8-hydroxyquinoline in 190 parts of 1,2-dichloroethane at 25 C. in the course of 5 minutes, and the mixture was stirred for 5 minutes. 9.2 parts of isoxazole-5-carbonyl chloride were then added at from 20 to 25 C. in the course of 10 minutes, while stirring, and stirring was continued for 3 hours at 55 C. The reaction mixture was evaporated to dryness under reduced pressure, and the residue was stirred in 200 parts of 0.5N hydrochloric acid for 5 minutes. The precipitate was filtered off under suction, washed with water and stirred for 10 minutes in 200 parts of dilute sodium carbonate solution. Filtration under suction, washing with water at 60 C. and drying gave 17.5 parts of 7-chloro-5-nitro-8-(isoxazole-5′-carbonyl)-oxyquinoline of melting point 132-134 C.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; BASF Aktiengesellschaft; US4829072; (1989); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

Example 90 N-{[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4- b]pyridin-5-yl]methyl}-5-isoxazolecarboxamideA solution of Intermediate 14 (20mg) in anhydrous acetonitrile (0.4ml) was treated with isoxazole-5-carbonyl chloride [e.g. available from Lancaster Synthesis Ltd.] (13mg) and DIPEA (0.016ml) and stirred at room temperature for 24 hours. The solution was blown to dryness and the residue was purified by mass directed autoprep HPLC to give Example 90 as a clear colourless gum (12mg). LCMS showed MH+ = 371; TREtau = 2.03min.

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/36733; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.,62348-13-4

General procedure: Compound 12a (0.05mmol, 20mg) and DIEA (0.075mmol, 9.75mg) were dissolved in 0.5mL of DMF and cooled to 0C, then propionyl chloride (0.06mmol, 5.5mg) was added to the system and the mixture was stirred at 0C for 1h. The system was extracted with EtOAc and dried with anhydrous Na2SO4. The solvents were removed under vacuum and the residue was purified by silica gel flash chromatography (DCM: MeOH=15: 1) to afford compound 13a (15mg, yield 65%).

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Article; Wang, Qiang; Liu, Feiyang; Qi, Shuang; Qi, Ziping; Yan, Xiao-E.; Wang, Beilei; Wang, Aoli; Wang, Wei; Chen, Cheng; Liu, Xiaochuan; Jiang, Zongru; Hu, Zhenquan; Wang, Li; Wang, Wenchao; Ren, Tao; Zhang, Shanchun; Yun, Cai-Hong; Liu, Qingsong; Liu, Jing; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 366 – 384;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4,62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 124 5-(isoxazol-5-oyl)amino-3-(1-methylpiperidin-4-yl)-1H-indole Beginning with 13 mg (0.056 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 8.21 mg (0.062 mMol) isoxazole-5-carbonyl chloride, 10.4 mg (57%) of the title compound were recovered. MS(m/e): 325(M+)

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; EP832650; (1998); A2;; ; Patent; ELI LILLY AND COMPANY; EP824917; (1998); A2;; ; Patent; Eli Lilly and Company; US5708008; (1998); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.,62348-13-4

A mixture of Compound 53 (70 mg, 0.11 mmol), 4-dimethylaminopyridine (30 mg, 0.25 mg), and isoxazole-5-carbonyl chloride (35 muL, 0.22 mmol) in 3.0 mL of dichloromethane was stirred at 21 C. for 5 hours. The reaction was quenched with saturated sodium bicarbonate solution, and aqueous layer was extracted with dichloromethane. The combined organic layers were dried over sodium sulfate and concentrated to afford a crude product, which was chromatographed to give the desired product. 1H NMR (300 MHz, CDCl3): delta 0.23 (s, 6H), 0.74 (m, 2H), 0.97 (m, 5H), 1.82 (m, 2H), 2.22 (m, 2H), 3.12 (m, 2H), 4.35 (t, J=6.9 Hz, 2H), 5.14 (m, 2H), 5.24 (s, 2H), 5.40 (d, J=17.4 Hz, 1H), 5.71 (d, J=17.4 Hz, 1H), 6.98 (d, J=1.8 Hz, 1H), 7.30 (m, 6H), 7.69 (t, J=6.0 Hz, 1H), 7.82 (t, J=8.4 Hz, 1H), 8.05 (d, J=7.8 Hz, 1H), 8.24 (d, J=8.4 Hz, 1H), 8.36 (d, J=1.8 Hz, 1H).

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Patent; BioNumerik Pharmaceuticals, Inc.; US2009/99224; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, a) Methyl 4-(4-isoxazol-5-yl(1,3-thiazol-2-yl))-5-methylthiothiophene-2-carboxylate Methyl 4-(aminothioxomethyl)-5-methylthiothiophene-2-carboxylate (872 mg, 2.51 mmol) was allowed to react with 2-bromo-1-isoxazol-5-ylethan-1-one (737 mg, prepared from from isoxazole-5-carbonyl chloride [Maybridge Chemicals, Cornwall, UK] as described in Example 177, step (a) as described in Example 154, step (a) to give 704 mg (83% yield) of methyl 4-(4-isoxazol-5-yl(1,3-thiazol-2-yl))-5-methylthiothiophene-2-carboxylate. 1H NMR (DMSO-d6, 300 MHz) delta 2.75 (s, 3H), 3.85 (s, 3H), 6.93 (d, 1H, J=1.8 Hz), 8.22 (s, 1H), 8.38 (s, 1H), 8.70 (d, 1H, J=1.8 Hz).

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; 3-Dimensional Pharmaceuticals, Inc.; US6291514; (2001); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4,62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of the corresponding acyl chloride (9.18 mmol) in chloroform (25 mL) was slowly added dropwise to a stirred solution of methyl imidoselenocarbamate hydroiodide (4.59 mmol) in dry chloroform (40 mL) and pyridine (5 mL). The mixture was stirred for 48 h at room temperature. Solvents were removed under vacuum by rotatory evaporation and the residue was treated with water (100 mL) and purified as indicated in Table 1. The spectroscopic data are shown in Table 2.

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Font, Maria; Lizarraga, Elena; Ibanez, Elena; Plano, Daniel; Sanmarti?, Carmen; Palop, Juan A.; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 489 – 498;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, Compound 61: {2-[(6,7-Dimethoxy-4-quinolyl)oxy]-5-methylphenyl}(5-isoxazolyl)methanone; 4-(2-Bromo-4-methylphenoxy)-6,7-dimethoxyquinoline (100 mg) was dissolved in tetrahydrofuran (6 ml) to prepare a solution which was then cooled to -78C. A 1.59 M n-butyllithium/hexane solution (0.4 ml) was added to the solution, and the mixture was stirred at -78C for 20 min. Isoxazole-5-carbonyl chloride (0.2 ml) was added to the reaction solution, and the mixture was stirred at room temperature overnight. Further, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using acetone-chloroform to give the title compound (27 mg, yield 26%). 1H-NMR (CDCl3, 400 MHz): delta 2.48 (s, 3H), 4.01 (s, 3H), 4.02 (s, 3H), 6.46 (d, J = 5.4 Hz, 1H), 6.81 (d, J = 1.9 Hz, 1H), 7.13 (d, J = 8.3 Hz, 1H), 7.24 (s, 1H), 7.40 (s, 1H), 7.49 (dd, J = 1.9, 8.3 Hz, 1H), 7.59 (d, J = 1.7 Hz, 1H), 8.25 (d, J = 1.9 Hz, 1H), 8.46 (d, J = 5.4 Hz, 1H) Mass spectrometric value (ESI-MS, m/z): 391 (M+1)+

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1548008; (2005); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.,62348-13-4

General procedure: Acyl chloride (1.1 equiv) was added to a suspension of 5(1.0 equiv) and potassium carbonate (10 equiv) in THF at roomtemperature under nitrogen. After 2 h, the reaction was quenchedby the addition of H2O and the resulting mixture was extractedwith EtOAc. The organic layer was dried over MgSO4, filtered,and concentrated under reduced pressure. The residue was purifiedby column chromatography to provide the desired products6a-6q.

As the paragraph descriping shows that 62348-13-4 is playing an increasingly important role.

Reference£º
Article; Chu, Kuang-Feng; Yao, Chun-Hsu; Song, Jen-Shin; Chen, Chiung-Tong; Yeh, Teng-Kuang; Hsieh, Tsung-Chih; Huang, Chung-Yu; Wang, Min-Hsien; Wu, Szu-Huei; Chang, Wei-En; Chao, Yu-Sheng; Lee, Jinq-Chyi; Bioorganic and Medicinal Chemistry; vol. 24; 10; (2016); p. 2242 – 2250;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem