Month: November 2022

Zhu, Cai-Cai published the artcileSynthesis of asymmetric biphenyl derivatives for optoelectronic applications, Name: 9-(4-Fluorophenyl)-9H-carbazole, the publication is Optical Materials (Amsterdam, Netherlands) (2013), 35(12), 2095-2101, database is CAplus.

We report the synthesis and optical properties of a series of ten organic compounds with biphenyl as the backbone and asym. modified by triphenylamines, carbazoles and tetraphenylsilanes (BP 1-10). BP 1-10 were synthesized mainly by Ullmann coupling reaction and Suzuki cross-coupling reaction and characterized by EA, NMR, MS, UV-Vis, DSC, TGA, fluorescence spectra and cyclic voltammetry. They exhibit reversible electrochem. behavior with low oxidation potentials and emit intense pure-blue light with high fluorescence quantum yields (up to 80%). BP 1 was fabricated into multi-layered light-emitting diodes as blue-emitting, host and hole transport materials. Based on the performance of BP 1 and the similarity in chem. structure to those compounds reported in literature, these compounds are expected to be good and versatile hole transport, host and blue emitting materials.

Optical Materials (Amsterdam, Netherlands) published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C24H20Ge, Name: 9-(4-Fluorophenyl)-9H-carbazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Yu, Chengxuan published the artcileClinical characteristics of hospitalized patients with drug-induced acute kidney injury and associated risk factors: a case-control study, Category: isoxazole, the publication is BioMed Research International (2020), 9742754, database is CAplus and MEDLINE.

Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clin. characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. A retrospective study among hospitalized patients was conducted in July 2019 based on the Adverse Drug Events Active Surveillance and Assessment System-2 developed by the authors. Four controls were matched with each case according to the matching criteria. The risk factors for D-AKI were identified by binary multivariate logistic regression. A total of 23,073 patients were hospitalized in July 2019, 21,131 of whom satisfied the inclusion criteria. The independent risk factors for D-AKI consisted of alc. abuse (odds ratio (OR), 2.05; 95% confidence interval (CI), 1.04-4.07), nonsteroidal anti-inflammatory drug (NSAID) use (OR, 2.39; 95% CI, 1.25-4.58), diuretic use (OR, 2.64; 95% CI, 1.42-4.92), prior anemia (OR, 4.10; 95% CI, 1.94-8.67), and prior chronic kidney disease (OR, 2.33; 95% CI, 1.07-5.08). The occurrence of D-AKI in hospitalized patients had significant associations with alc. abuse, combination therapy with NSAIDs or diuretics, and prior anemia or chronic kidney disease. Clinicians should meticulously follow patients with the above characteristics.

BioMed Research International published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C4H6O3, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

El Kaim, Laurent published the artcileThree-component Nef-Huisgen access to 1,2,4-triazoles, Application In Synthesis of 2251-79-8, the publication is Synlett (2009), 1315-1317, database is CAplus.

A three-component triazole synthesis involving a Nef-Huisgen cascade reaction is described. After the α-addition of acyl chlorides onto isocyanides (Nef reaction), the resulting imidoyl chloride is treated with tetrazoles under suitable activation (ZnCl₂). The resulting adduct is unstable and evolves according to the Huisgen reaction.

Synlett published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Application In Synthesis of 2251-79-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wu, Yehui published the artcileLow-cost and efficient hole transport materials based on 9-phenyl-9H-carbazole branch for perovskite solar cells, Name: 9-(4-Fluorophenyl)-9H-carbazole, the publication is Surfaces and Interfaces (2022), 101598, database is CAplus.

Hole transport materials (HTMs) play a pivotal role in the hole extraction and transportation processes in perovskite solar cells (PSCs). Although a great number of HTMs based on various planar conjugated cores have been explored, the development of branches is rather limited. In this work, branches of 9-phenyl-9H-carbazole derivatives have been incorporated in different N-alkylated dithieno[3,2-b:2�3�d]pyrrol (DTP) core to construct HTMs (TM-9 to TM-14). Among them, TM-13 with 9-(4-methoxyphenyl)-9H-carbazole branch exhibites excellent performance in hole extraction and transportation ability. Consequently, the PSCs based on TM-13 have achieved the power conversion efficiency (PCE) of 20.44%, which is comparable to the PCE of 20.62% with the widely used Spiro-OMeTAD HTM. More importantly, the synthetic cost of TM-13 (62 dollar/g) is much lower than that of Spiro-OMeTAD (400 dollar/g), suggesting its promising commercialization for low-cost and efficient HTMs for PSCs.

Surfaces and Interfaces published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C15H21BO2, Name: 9-(4-Fluorophenyl)-9H-carbazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhou, Xiao-dao published the artcileInfluence of parecoxib Na on anesthesia recovery period of patients under the fast track anesthesia with remifentanil, Product Details of C19H17N2NaO4S, the publication is Zhongguo Linchuang Yaolixue Zazhi (2015), 31(9), 708-711, database is CAplus.

Objective To investigate the effects of preoperative use of parecoxib Na during anesthesia recovery period on the fast track anesthesia with remifentanil. Methods A total of 105 cases who received laparoscopic cholecystectomy were randomly divided into three groups with 35 cases in each group. Patients in group A received parecoxib Na 40 mg dissolved in normal saline 10 mL through injection 20 min before induction of anesthesia. Patients in group B received parecoxib Na 40 mg dissolved in normal saline10 mL through injection 20 min before the end of surgery. Patients in group C received normal saline 10 mL through injection 20 min before induction of anesthesia. The data of mean arterial pressure (MAP), heart rate (HR) and oxygen saturation (SPO₂), verbal rating scale (VRS), sedation-agitation scale (SAS), Ramsay sedation scale (RSS) and comfort score (BCS) were compared among three groups. Results The data of MAP, SAS and HR in group A and group B were significantly lower than those in group C, and the data of MAP, SAS and HR in group A were significantly lower than those in group B (P<0.05). The data of RSS in group A was significantly lower than that in group B and RSS in group A and group B significantly higher than those in group C from T₂ to T₄ (P<0.05). The data of VRS in group A and group B were significantly lower than those in group C, and that in group A was significantly lower than group B each time point (P<0.05). Postoperative BCS in group A and group B were significantly higher than those in group C, and that in group A was significantly higher than group B (P<0.05). Conclusion Preoperative use of parecoxib Na could significantly reduce the acute pain of the fast track anesthesia with remifentanil, effectively inhibiting hyperalgesia and reducing the patient’s agitation.

Zhongguo Linchuang Yaolixue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C12H9N3O4, Product Details of C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wu, Xiulan published the artcileFace-to-face order-packed mode promotes thermally activated delayed fluorescence to achieve stronger aggregation-induced emission, HPLC of Formula: 57103-14-7, the publication is Journal of Science: Advanced Materials and Devices (2022), 7(2), 100432, database is CAplus.

Two novel aggregation-induced delayed fluorescence materials (AIDF) FCP-BP-PXZ [9- (4-Fluorophenyl) -9H-carbazole-3-yl] [4- (10H-phenoxazine-10-yl) phenyl] methane and FCP-BP-PTZ [9- (4-Fluorophenyl) -9H-carbazole-3-yl] [4- (10H-penzothiazin-10-yl) phenyl] methane were synthesized. Experiments and mol. dynamics (MD) simulations revealed that FCP-BP-PXZ exhibits orderly face-to-face arrangement stacking mode, which inhibits non-radiation inactivation channel and reduces energy loss by restricting larger vibration and rotation of the mol. due to abundant intermol. hydrogen bonds and strong intermol. π-π interactions. FCP-BP-PTZ′s performance was hampered by erratic relaxation aggregation. The maximal external quantum efficiency (EQE_max) of non-doped and doped organic light-emitting diodes (OLEDs) constructed on FCP-BP-PXZ was 11.2% and 18.2%, resp. Furthermore, at a brightness of 1000 cd m^-2, non-doped and doped devices had a low turn-on voltage of 3.0-3.5 V, with 2.0% and 3.3% efficiency roll-off, owing to the microsecond-scale delayed lifetime. The FCP-BP-PXZ-based non-doped device, in particular, achieved a brightness of 62,390 cd m^-2, which was crucial in non-doped yellow OLEDs.

Journal of Science: Advanced Materials and Devices published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C22H18O2, HPLC of Formula: 57103-14-7.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Sagadevan, Arunachalam published the artcileVisible-Light Copper Nanocluster Catalysis for the C-N Coupling of Aryl Chlorides at Room Temperature, Formula: C18H12FN, the publication is Journal of the American Chemical Society (2022), 144(27), 12052-12061, database is CAplus and MEDLINE.

A copper nanocluster-based catalyst, [Cu₆₁(S^tBu)₂₆S₆Cl₆H₁₄] (Cu₆₁NC) that enabled C-N bond-forming reactions of aryl chlorides under visible-light irradiation at room temperature A range of N-heterocyclic nucleophiles and electronically and sterically diversed aryl/hetero chlorides react in this new Cu₆₁NC-catalyzed process to afford the C-N coupling products in good yields. Mechanistic studies indicated that a single-electron-transfer (SET) process between the photoexcited Cu₆₁NC complex and aryl halide enabled the C-N-arylation reaction.

Journal of the American Chemical Society published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C18H12FN, Formula: C18H12FN.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Davies, Ian W. published the artcileThe influence of ligand bite angle on the enantioselectivity of copper(II)-catalyzed Diels-Alder reactions, Category: isoxazole, the publication is Chemical Communications (Cambridge) (1996), 1753-1754, database is CAplus.

Novel spirobis(oxazoline) complexes, formed from I (n = 1-4), provide excellent levels of stereocontrol in copper-catalyzed Diels-Alder reactions; the larger the ligand bite angle, the higher the enantioselection (up to 98.4% ee).

Chemical Communications (Cambridge) published new progress about 182122-10-7. 182122-10-7 belongs to isoxazole, auxiliary class BOX or PyBox,BOX or PyBox, name is (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), and the molecular formula is C24H22N2O2, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Sun, Li-ping published the artcileApplication of advanced analgesia in early rehabilitation after knee replacement, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Zhongguo Jiaoxing Waike Zazhi (2016), 24(21), 2004-2006, database is CAplus.

[Objective]: The article observed the clin. efficacy of advanced anti-inflammatory analgesia in early functional rehabilitation after knee replacement. [Methods]: The article randomly divided 60 patients with unilateral knee arthroplasty who were admitted to our hospital from June 2013 to Jan. 2015 into two groups, 30 in each group, and celecoxib in the advanced analgesia group combined with parecoxib sodium for advanced analgesia, the analgesia pump group used postoperative i.v. analgesia pump. The article recorded the VAS scores of patients at rest at 6, 12, 24, 48, and 72 h postoperatively, the knee joint mobility, and the number of adverse reactions at 1, 2, 3, 7, and 14 days after surgery for statistical anal. [Result]: The postoperative analgesia effect of the advanced analgesia group was significantly better than that of the analgesia pump group (P < 0.05), the range of knee movement was significantly greater than that of the analgesia pump group (P < 0.05), and the number of adverse reactions was significantly less In the analgesic pump group (P < 0.05). [Conclusion]: Advanced anti-inflammatory analgesia could obviously eliminate the pain after knee replacement, and early rehabilitation of knee function could be performed.

Zhongguo Jiaoxing Waike Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C27H39ClN2, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Tang, Ni published the artcileEffect of paricoxib sodium on postoperative cognitive function in elderly depression rats, Product Details of C19H17N2NaO4S, the publication is Yiyao Daobao (2016), 35(1), 12-15, database is CAplus.

Objective To investigate the effect of paricoxib sodium on postoperative cognitive dysfunction (POCD) in elderly depression rats. Methods The total of 36 elderly male Sprague Dawley (SD) rats were divided into 3 groups: normal control group (n = 6); surgical group (Sur group, n = 15); paricoxib sodium group (Pare group, n = 15). Depression models were established in rats except those in the normal control group. The 5 mg·kg^-1 paricoxib sodium was i. p. injected in the Pare group 1 h prior to, 8 h, 2 d and 3 d post operation, resp. And 0.9% sodium chloride injection was i. p. injected into the Sur group. Behavior and cognition of all animals were evaluated by open-field, sucrose consumption and Morris water maze tests. IL-6 and IL-1β expression were detected by Elisa. Results The escape latency was (39.98±8.93) s in Pare group vs (47.15±10.87) s in Sur group (P<0.05); and the space exploration was (24.17±8.52) s vs (20.96±9.58) s (P<0.05). IL-6 expression was (72.86±6.82) in Pare group vs (79.26±4.19) ng·L^-1 in Sur group, IL-1β expression was (350.73±28.04) vs (423.35±26.81) ng·L^-1 (P<0.05). The horizontal and vertical scores were significantly higher in Pare group than those in the Sur group (P<0.05). The sucrose consumption and sucrose preference were higher and the water consumption was lower in Pare group than those in the Sur group (P<0.05). Conclusion Parecoxib sodium may improve postoperative cognition of elderly rats with depression, which being associated with decrease of IL-6 and IL-1β expression in hippocampus.

Yiyao Daobao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C5H8N2O, Product Details of C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem