Day: November 21, 2022

Sun, Xiu-rong published the artcileObservation on analgesic effect of parecoxib sodium on patients undergoing subtotal thyroidectomy, Formula: C19H17N2NaO4S, the publication is Shiyong Yaowu Yu Linchuang (2016), 19(5), 599-601, database is CAplus.

To discuss the analgesic effect of parecoxib sodium on patients who have undergone subtotal thyroidectomy. The clin. data of 105 cases who had undergone subtotal thyroidectomy in our hospital from Nov. 2014 to Nov. 2015 were collected. The patients were given i.v. injection of parecoxib sodium (40 mg) 15 min before the end of operation (group A). The patients were given i.v. injection of parecoxib sodium (40 mg) immediately after patients returned to the wards (B group). The patients were given i.v. injection of NS (2 mL) solution 15 min before the end of operation (group C). Each group included 35 cases. The visual simulation pain score (VAS score) at 0, 2, 4, 6, 12, and 24 h after returning to the ward, postoperative analgesia satisfaction rate 1 d after operation and the incidence of side effects of the three groups were observed and compared. The VAS scores of A and B groups at each time point were significantly lower than that of C group, with statistically significant difference (P < 0.05). The VAS scores of A group (0, 2 h) were lower than those of B group, with statistically significant difference (P < 0.05). The postoperative occurrence rate of side effects of the three groups had no statistical significance (P > 0.05). Application of parecoxib during or after thyroid subtotal surgery can reduce postoperative pain and increase satisfaction of analgesic effect. Moreover, application of parecoxib is safe and reliable. Giving i.v. injection of parecoxib sodium 15 min before the end of surgery is a better choice.

Shiyong Yaowu Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C7H5ClN2S, Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Song, Jie published the artcileEffect of parecoxib sodium on inflammatory mediator and postoperative cognitive dysfunction after laparoscopic surgery in elderly patients, Synthetic Route of 198470-85-8, the publication is Guoji Mazuixue Yu Fusu Zazhi (2015), 36(6), 493-495, 501, database is CAplus.

The effects of parecoxib Na on inflammatory mediator and postoperative cognitive dysfunction (POCD) after laparoscopy surgery in elderly patients were studied. Eighty ASA patients phys. status I or II of both sexes, aged over 65 yr, weighing 45-70 kg, undergoing laparoscopic cholecystectomy, were randomly divided into parecoxib Na (group P, n=40) and control groups (group C, n=40). The patients in group P were given i.v. parecoxib 40 mg before induction of anesthesia. Ones in group C were given equal volume normal saline instead of parecoxib. Neuropsychol. testing was performed with mini-mental state examination (MMSE) on the preoperative day, 1st and 3rd postoperative day. Venous blood samples were collected before induction of anesthesia (T₀), immediately after skin incision (T₁), 30 min after CO₂ pneumoperitoneum (T₂), at the end of operation (T₃), the first day of operation (T₄), the third day of operation(T₅) for determination of serum concentrations of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) by enzyme linked immunosorbent assay (ELISA). The development of POCD was recorded within 3 days after surgery. Compared with preoperative 24 h [group C (28.2±1.2), group P (28.8±1.0)], the MMSE scores of resting in group C and group P were significantly reduced [(23.0±2.5), (25.0±2.8)] (P<0.05). The MMSE scores of resting in group P were more than those in group C [(25.0±2.8) vs (23.0±2.5)] (P<0.05). The development of POCD within 72 h was less than that in group C (P<0.05). Compared with group C, the serum concentrations of TNFa [(11.8±1.7), (13.8±1.3), (12.3±1.6) ng/L] and IL-6 [(11.8±1.7), (13.8±1.3), (12.3±1.6) ng/L] at T₃-T₅ were significantly decreased in group P (P<0.05). Compared with T₀, the serum concentrations of TNF-α and IL-6 at T₃-T₅ were increased in two group (P<0.05). Parecoxib Na might decrease the development of POCD in elderly patients undergoing laparoscopic cholecystectomy by inhibition of inflammatory responses.

Guoji Mazuixue Yu Fusu Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C7H6O3, Synthetic Route of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhang, Xinyuan published the artcileIsoxazolone-based single crystals with large second harmonic generation effect, Application In Synthesis of 1076-59-1, the publication is CrystEngComm (2015), 17(38), 7316-7322, database is CAplus.

Two nonlinear optical (NLO) crystals based on the 3-phenyl-5-isoxazolone moiety, (Z)-4-(4-(dimethylamino)benzylidene)-3-phenylisoxazol-5(4H)-one (C₁₈H₁₆N₂O₂, DLS) and (Z)-4-(4-methoxybenzylidene)-3-phenylisoxazol-5(4H)-one (C₁₇H₁₃NO₃, MLS), have been successfully grown by a slow evaporation method. The powder second-harmonic generation intensities of DLS and MLS are strong, about 2.8 and 1.5 times that of OH1, resp. Such a large SHG effect is further elucidated by structure analyses and theor. calculations The optical and thermal properties of DLS and MLS have been characterized by UV-vis absorption spectroscopy, IR spectroscopy, thermal gravimetric anal. and differential scanning calorimetry.

CrystEngComm published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C10H15NO, Application In Synthesis of 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhang, Xinyuan published the artcileMolecular design on isoxazolone-based derivatives with large second-order harmonic generation effect and terahertz wave generation, SDS of cas: 1076-59-1, the publication is CrystEngComm (2016), 18(20), 3667-3673, database is CAplus.

A series of 3-phenyl-5-isoxazolone and 3-methyl-5-isoxazolone-based compounds with different electron donors were synthesized. Fourteen single crystals in this family were obtained by slow evaporation Single crystal X-ray studies showed that four new 3-phenyl-5-isoxazolone-based crystals, C₂₀H₁₈N₂O₂ (PDI), C₁₅H₁₁NO₂S (PTI), C₂₃H₁₅NO₂ (PFI), and C₁₇H₁₃NO₂S (PMI-(I)), belong to the noncentrosymmetric space group. The inclinations to achieve noncentrosym. space groups in the 3-phenyl-5-isoxazolone-based crystals have been confirmed by first-principles calculations Powder second harmonic generation (SHG) tests revealed that the abovementioned four acentric crystals exhibited very large SHG intensities that were about 1 to 3 times that of OH1 (a commonly used nonlinear optical crystal) under 2.09μm light. Their UV-vis absorption, diffuse reflectance spectroscopy, and thermal properties were also characterized. Moreover, widely tunable and monochromatic terahertz difference frequency generation in the 3-phenyl-5-isoxazolone-based crystal C₁₇H₁₃NO₃ (MLS) was realized for the first time.

CrystEngComm published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C10H15NO, SDS of cas: 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wang, Yu published the artcileAnalgesic effect of parecoxib sodium and tramadol in painless induced abortion, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Sichuan Yixue (2015), 36(1), 100-102, database is CAplus.

Objective: To compare the effect of parecoxib sodium and tramadol in combination with propofol on postoperative analgesia in painless induced abortion. Methods: 120 Cases of pregnant women of ASA I-II grade undergoing painless induced abortion were randomly divided into three groups. P group was preoperatively injected with 40 mg of parecoxib sodium, Q group was preoperatively injected with 100 mg of tramadol, and X group was preoperatively injected with 40 mg of parecoxib sodium and 100 mg of tramadol, and all groups were treated with 1.5-2.5 mg/kg propofol for anesthesia. The intraoperative consumption of propofol, intraoperative and postoperative analgesic effect and adverse reactions in the three groups were compared. Results: The intraoperative consumption of propofol in X group was significantly lower than that in P group and Q group (P < 0.05). All groups have good intraoperative analgesic effect without statistically significant difference (P > 0.05). The uterine contraction pain VAS scores at each time point during surgery in X group were significantly lower than those in P group and Q group, with statistically significant differences (P < 0.05). The difference of incidence of nausea and vomiting between the three groups was not statistically significant (P > 0.05). Conclusion: Application of parecoxib sodium combined with tramadol in painless induced abortion can reduce the intraoperative consumption of propofol, and has better efficacy than simple parecoxib sodium or tramadol.

Sichuan Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H14O2, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Luo, Pengfei published the artcileEffects of parecoxib sodium on cognitive function of elderly patients after hepatectomy for liver cancer, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Zhongguo Putong Waike Zazhi (2014), 23(7), 887-892, database is CAplus.

The effects of using parecoxib sodium for analgesia on post-hepatectomy cognitive function in elderly patients were investigated. Eighty patients over 60 years of age undergoing elective hepatectomy for liver cancer were randomly assigned into observational group and control group, with 40 cases in each group. Patients in observational group received parecoxib sodium administration after surgery (40 mg, i.v. injection, and once per 12 h for 3 d), and those in control group were given normal saline as placebo. And addnl. tramadol was used in either group according to need for analgesia to maintain the pain visual analog scale (VAS) not more than a score of 3. The Wechsler Adult Intelligence Scale (WAIS) and Wechsler Memory Scale (WMS) were used to test the incidence of postoperative cognitive dysfunction (POCD) in both groups of patients, and the blood levels of S-100β protein, inflammatory cytokines, cortisol, and ammonia were detected before surgery and on several time points after surgery. The perioperative data between the two groups of patients showed no statistical difference. The incidence of POCD was significantly lower in observational group than that in control group (7.5% vs. 2.5%, P<0.05). The levels of cortisol, interleukin-4 (IL-4) and ammonia had no significant alteration in both group at any postoperative time points compared with their preoperative levels. The levels of S-100β protein, IL-6, tumor necrosis factor-α (TNF-α), IL-1β and C-reactive protein (CRP) in both groups were significantly increased in different time spans with varying degrees in both groups compared with their preoperative levels, but the increasing degrees of S-100β protein and IL-6 in observational group were less than those in control group within postoperative 24 and 48 h, resp. Parecoxib sodium administration could help improve the post-hepatectomy cognitive function in elderly patients, and the mechanism might probably associated with its decreasing the S-100β and IL-6 levels.

Zhongguo Putong Waike Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Sibi, Mukund P. published the artcilePractical and Efficient Enantioselective Conjugate Radical Additions, Name: (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), the publication is Journal of Organic Chemistry (1997), 62(12), 3800-3801, database is CAplus.

Outstanding levels of enantioselectivity (up to 97% ee) using catalytic amounts of chiral Lewis acids in conjugate radical additions was achieved. Addnl., high levels of enantioselectivity at room temperature using sub-stoichiometric amounts of chiral Lewis acid are also reported. Thus, iso-Pr radical addition to N-cinnamoyl oxazolidinone at -78° using a chiral Lewis acid derived from MgI₂ and chiral bioxazoline (4S,5R)-I in sub-stoichiometric yield (40 mol %) provides conjugate addition product (R)-II of high optical purity (94% isolated yield, 97% ee). The effects of bite angle and dihedral angle in a variety of chiral bioxazoline ligands on the enantioselectivity and absolute stereochem. of the conjugate radical addition reaction were studied.

Journal of Organic Chemistry published new progress about 182122-10-7. 182122-10-7 belongs to isoxazole, auxiliary class BOX or PyBox,BOX or PyBox, name is (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), and the molecular formula is C15H10O2, Name: (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole).

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Barnes, David M. published the artcileDevelopment of a catalytic, asymmetric Michael addition in the synthesis of endothelin antagonist ABT-546, Recommanded Product: (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), the publication is ACS Symposium Series (2002), 45-59, database is CAplus.

The selective endothelin A antagonist ABT-546 I is prepared enantioselectively on large (13 mol) scale using the catalytic addition of ketoester II to nitrostyrene III in the presence of bisoxazoline IV and magnesium triflate as the key step. E.g., magnesium triflate is hydrated in chloroform; ligand IV is added and the mixture stirred for about 1 h to generate the active catalyst. E.g., II and III are added with mol. sieves to give a 0.2 M solution; N-methylmorpholine is added as an amine cocatalyst when the mixture is dry and the reaction is stirred to give intermediate V in 83% yield and 88% ee on 13 mol scale. The Michael addition reaction was extensively optimized. No other bisoxazoline ligand tested was as effective as IV. Other magnesium salts with coordinating anions are less effective as catalysts. An amine cocatalyst is necessary for high stereoselectivity in the Michael addition Chloroform is the best solvent for the Michael addition, although toluene also is effective. The presence of water during the generation of the active catalyst is necessary for high yields, but the presence of water during the reaction inhibits the reaction and decreases selectivity; the use of mol. sieves is necessary to obtain product in high yields. The purity of the substrates in the enantioselective Michael addition is important for good rates and selectivities. The scope of the asym. Michael addition reaction of ketoesters to nitroolefins to give nitroketoesters is extended to other ketoester and malonate nucleophiles such as di-Et malonate, and to other nitroolefins such as β-nitrostyrene and 1-nitro-1-heptene.

ACS Symposium Series published new progress about 182122-10-7. 182122-10-7 belongs to isoxazole, auxiliary class BOX or PyBox,BOX or PyBox, name is (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole), and the molecular formula is C24H22N2O2, Recommanded Product: (3aS,3a’S,8aR,8a’R)-2,2′-(Cyclobutane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole).

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wang, Lei published the artcileSite-Selective N-Arylation of Carbazoles with Halogenated Fluorobenzenes, Category: isoxazole, the publication is Synthesis (2016), 48(5), 737-750, database is CAplus.

A method for the highly site-selective C-N bond-formation reaction of halogenated fluorobenzenes with carbazoles was described. The selectivity of iodine and fluorine atoms on the aromatic ring of fluorinated iodobenzenes was initially determined with a copper-N,N-diisopropylethylamine catalytic system. By changing the position of the iodine atom on the aromatic ring from the 3- or 4-position to the 2-position, the preferred coupling site was switched from the iodine atom to the fluorine atom. Steric hindrance of the fluorinated iodobenzenes was responsible for the selectivity switch. After elucidating the reaction mechanisms of these reaction processes, a metal-free method for the highly site-selective C-N bond-formation reaction of halogenated fluorobenzenes with carbazoles was revealed through C-F bond activation. The metal-free system was able to handle a range of halogenated groups. Thus, a broad range of chlorinated, brominated, and iodinated N-arylated carbazoles were generated, which are widely useful in organic chem.

Synthesis published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C8H6ClF, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Esmaeilpour, Mohsen published the artcileFacile synthesis of 1- and 5-substituted 1H-tetrazoles catalyzed by recyclable ligand complex of copper(II) supported on superparamagnetic Fe₃O₄@SiO₂ nanoparticles, Recommanded Product: 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, the publication is Journal of Molecular Catalysis A: Chemical (2014), 18-29, database is CAplus.

A new method for preparing functionalized superparamagnetic Fe₃O₄@SiO₂ possessing high saturation magnetization was reported. Magnetite particles were prepared by simple co-precipitation method in aqueous medium, and then Fe₃O₄@SiO₂ nanosphere was synthesized by using nano Fe₃O₄ as the core, TEOS as the silica source and polyethylene glycol (PEG 1000) as the surfactant. Then, the silica-coated Fe₃O₄ nanoparticles were covered with ligand complex of Cu(II). The functionalized magnetic core-shell nanoparticles (MNPs) were investigated by Fourier transform IR spectroscopy, transmission electron microscopy, SEM, X-ray diffraction, thermogravimetric anal., dynamic light scattering and N₂ adsorption/desorption. Also, its Cu content was determined by inductively coupled plasma (ICP) analyzer. Then, the immobilized copper complex was used as an efficient catalyst for synthesis of 1- and 5-substituted 1H-tetrazoles from nitriles and amines in good to excellent yields. The results show that the supported catalyst could be conveniently recovered through the use of an external magnetic field and reused for subsequent reactions for at least 6 times with less deterioration in catalytic activity.

Journal of Molecular Catalysis A: Chemical published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Recommanded Product: 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem