Day: November 21, 2022

Lavanya, M. published the artcileSynthesis, crystal structure, DNA binding and antitumor studies of β-diketonate complexes of divalent copper, zinc and palladium, Related Products of isoxazole, the publication is Inorganica Chimica Acta (2018), 76-86, database is CAplus.

This paper reports a simple approach for the synthesis of three pairs of novel mononuclear β-diketonate complexes of copper(II), zinc(II) and palladium(II) from monobasic O-O donor ligands 3-phenyl-4-fluorobenzolyl-5-isoxazolone (HL¹) and 3-phenyl-4-toluyl-5-isxoazolone (HL²). The synthesized compounds were characterized by FTIR, ESI/FAB mass, ¹H NMR, UV-visible and thermogravimetric analyses. The free ligand HL¹ and the copper(II) complex, [Cu(L²)₂(CH₃OH)₂] are unambiguously characterized by single crystal x-ray diffraction studies. The free ligand HL¹ has adopted orthorhombic crystal system with P2(1) space group and a 8.1552(3), b 10.1169(4), c 17.0819(6) Å, and α = β = γ 90.°. The crystal structure of the complex, [Cu(L²)₂(CH₃OH)₂] is monoclinic with P2(1)/c space group and a 10.2571(2), b 16.2640(3), c 20.1717(3) Å, and α 90.β 99.56 and γ 90.°. The copper(II) complex has adopted distorted octahedral geometry where the z-axis is occupied by two solvent methanol mols. according to the crystal data. While the EPR spectra of both the Cu(II) complexes display a strong axial signal with g_vbr â‰?2.2 and gbottom â‰?2.0, which obviously suggests the square planar geometry around the copper(II) ion. The interaction of the complexes with calf thymus DNA (CT-DNA) was studied using UV-visible and fluorescence spectroscopic techniques. Anticancer activity of the complexes revealed their potential towards inhibiting the growth of human breast cancer cell lines, MDA-MB-231. The palladium complexes of both the ligands are good in exhibiting apoptosis. Also, the complexes of fluoro-substituted ligand are better antimicrobial agents when compared with those of Me substituted ligand.

Inorganica Chimica Acta published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Galenko, Ekaterina E. published the artcileSynthesis of N-aminopyrazoles by Fe(II)-catalyzed rearrangement of 4-hydrazonomethyl-substituted isoxazoles, Category: isoxazole, the publication is Tetrahedron (2018), 74(43), 6288-6298, database is CAplus.

A novel effective method is reported for the preparation of 1-amino-1H-pyrazole-4-carboxylic acid derivatives by Fe(II)-catalyzed rearrangement of isoxazoles having (2,4-dinitrophenylhydrazono)methyl substituent at C4. The reaction proceeds smoothly for both E and Z isomers of 4-(hydrazonomethyl)isoxazoles, and this means it is not necessary to sep. mixtures of E/Z-isomers of the hydrazones prepared by reaction of 5-methoxy/pirrolidino-4-carbonylisoxazoles and 2,4-dinitrophenylhydrazine. The rearrangement proceeds via the formation of an aziridine intermediate which can be isolated in certain cases. The 2-nitro group in the synthesized 1-[(2,4-dinitrophenyl)amino]-1H-pyrazole-4-carboxylic esters can be selectively reduced in two steps via acylation of the amino group followed by hydrogenation-deacylation using H₂-Pd/C.

Tetrahedron published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Tang, Dong published the artcileIodine-catalyzed synthesis of sulfonyl isoxazoles from sodium sulfinates and isoxazol-5(4H)-ones, Product Details of C9H7NO2, the publication is Tetrahedron Letters (2021), 152685, database is CAplus.

An efficient I₂-mediated sulfonylation at 4-position of isoxazoles has been developed by employing sodium sulfinate and 3-substituted isoxazol-5(4H)-ones. This metal-free, one-pot strategy provides various sulfonyl isoxazoles under mild reaction conditions. The final product exists in the form of stable organic sodium salt, which can be purified by column chromatog. under air.

Tetrahedron Letters published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C18H15N3O3, Product Details of C9H7NO2.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Long, Hao published the artcileSafety and efficacy of parecoxib sodium in multimode analgesia after osteoarticular surgery, HPLC of Formula: 198470-85-8, the publication is Zhongguo Jiaoxing Waike Zazhi (2014), 22(5), 458-460, database is CAplus.

Objective: To evaluate the safety and efficacy of parecoxib sodium in multimode analgesia after osteoarticular surgery. Methods: 90 patients were divided into group A (parecoxib sodium combined with fentanyl PCIA) and group B (fentanyl PCIA). Group A is further divided into group A 1: venous group (40 mg/time, 1 time/12 h i.v. infusion) and A 2 group: s.c. injection group (40 mg/ time 1 time /12 h). The VAS score, fentanyl dosage and ADR, PCA press number and effective number of each group at 48 h postoperatively were compared. Results: Group A and group B had statistically significant difference in VAS score, fentanyl dosage and ADR, PCA press number and effective (P < 0.05 ). In group A, the venous group and s.c. injection group had no statistically significant difference (P>0.05). Conclusion: The parecoxib sodium combined with PCA multimode analgesia can reduce fentanyl dose and alleviate pain at 48 h postoperatively.

Zhongguo Jiaoxing Waike Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, HPLC of Formula: 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Xu, Shiyang published the artcileRh(III)-Catalyzed C-H Activation of Boronic Acid with Aryl Azide, COA of Formula: C18H12FN, the publication is Organic Letters (2018), 20(18), 5578-5582, database is CAplus and MEDLINE.

A Rh(III)-catalyzed C-H activation of boronic acid with aryl azide to obtain unsym. carbazoles, 1H-indoles, or indolines has been developed. The reaction constructs dual distinct C-N bonds via sp²/sp³ C-H activation and rhodium nitrene insertion. Synthetically, this approach represents an access to widely used carbazole derivatives The practical application to CBP and unsym. TCTA derivatives has also been performed. Mechanistic experiments and DFT calculations demonstrate that a five-membered rhodacycle species is the key intermediate.

Organic Letters published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C14H12N2S, COA of Formula: C18H12FN.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Li-biao published the artcileComparison of pain thresholds and analgesic effects of parecoxib sodium in surgical patients of different racial and religious backgrounds, Synthetic Route of 198470-85-8, the publication is Zhongguo Yixue Kexueyuan Xuebao (2015), 37(3), 325-330, database is CAplus and MEDLINE.

The aim is to explore the differences of pain thresholds and analgesic effects of parecoxib sodium among patients with different racial and religious backgrounds. A total of 48 male patients aged 18 to 38 years who had undergone elective laparoscopic appendectomy under general anesthesia in our center were enrolled in our study, and then divided into 6 groups(n=8 in each group) based on their racial backgrounds(three levels: Mongoloid, Negroid, and Europoid) and religious backgrounds(two levels: without religion background, with religion background). All subjects received same anesthesia, surgical procedure, and postoperative analgesia with parecoxib sodium. The temperature pain threshold and elec. pain threshold were detected 1 h before and after analgesia. The threshold of pain was higher in Europoids than that in Negroids and Mongoloids before and after treatment. The temperature pain threshold and elec. pain threshold were not significantly different between subjects with or without religious background(before analgesic therapy: F=251.119, P=0.130, F=275.861, P=0.059; after analgesic therapy: F=308.531, P=0.086, F=180.062, P=0.078). Also, there was no interaction between the racial and religious backgrounds in terms of temperature pain threshold and elec. pain threshold(F=13.553, P=0.091, F=22.001, P=0.089; after analgesic therapy: F=4.624, P=0.089, F=15.935, P=0.094). The threshold of pain differed among individuals with different racial background, and it was the highest in Europoids, followed by Negroids and Mongoloids. It showed no obvious difference in people with different religious backgrounds.

Zhongguo Yixue Kexueyuan Xuebao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Synthetic Route of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Zhang, Chaofeng published the artcileParacoxib Alleviates Ventilator-Induced Lung Injury Through Functional Modulation of Lung-Recruited CD11bloLy6Chi Monocytes, Formula: C19H17N2NaO4S, the publication is Shock (2021), 55(2), 236-243, database is CAplus and MEDLINE.

Lung-recruited Ly6Chi monocytes had been shown to be involved in ventilator-induced lung injury (VILI). Our present study aimed to investigate whether the cyclooxygenase-2 (COX-2) inhibition modulates the function of lung-recruited Ly6Chi monocytes in a mouse model of VILI. Mice were exposed to lipopolysaccharide (LPS; 20 ng) i.p. prior to injurious mech. ventilation (Vt=30mL/kg, PEEP=0cmH2O). A subgroup of mice was treated with i.v. parecoxib (30mg/kg), a COX-2 inhibitor, 1 h prior to ventilation. Control mice received saline and were not ventilated. At the end of the experiment, blood gas anal. was performed and lung tissue was collected for histol. assessment. Flow cytometry was employed to quantify the different populations of lung monocytes/macrophages and their function. Isolated Ly6Chi cells were used to measure the intracellular concentrations of reactive oxygen species (ROS) and nitric oxide (NO) by fluorescent probes, and cytokine production by cytometric bead array. Exposure to LPS and injurious ventilation was associated with severe lung histol. damage, oxygenation impairment, and pulmonary edema; all of which were largely attenuated following the treatment of parecoxib. Furthermore, flow cytometry anal. revealed that parecoxib caused a reduction in the number of the lung-recruited CD11bloLy6Chi monocytes while there was no effect on tissue-resident CD64+ alveolar macrophages. In addition, the production of oxidative stress products (ROS, NO), MHC-II expression, and inflammatory cytokines in response to LPS and VILI in CD11bloLy6Chi monocytes was ameliorated by parecoxib. Parecoxib-induced alleviation of oxidative stress and inflammation in lung-recruited Ly6Chi monocytes may partly explain the beneficial action of COX-2 inhibition in VILI.

Shock published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C7H6Cl2, Formula: C19H17N2NaO4S.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Deng, Li-Qin published the artcileEffect of pre-emptive analgesia by continuous femoral nerve block on early postoperative cognitive function following total knee arthroplasty in elderly patients, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Experimental and Therapeutic Medicine (2017), 13(4), 1592-1597, database is CAplus and MEDLINE.

To the best of our knowledge, the effect of pre-emptively blocking pain transmission on acute postopera- tive cognitive dysfunction (POCD) has not yet been assessed. Therefore, the present study aimed to investigate the effect of pre-emptive analgesia via a continuous femoral nerve block (CFNB) on postoperative pain and early cognitive function following total knee arthroplasty (TKA) surgery in elderly patients. CFNB was performed prior to TKA surgery in the pre- emptive analgesia group (n=30) and following TKA surgery in the control group (n=30). POCD was defined as a two-point reduction in the postoperative score compared with the preop- erative score in the mini-mental state examination The visual analog scale (VAS) was used to evaluate the intensity of pain at rest and during exercise. The intraoperative dose of remi- fentanil in the pre-emptive analgesia group was significantly lower than in the control group (P<0.01). In the preemptive analgesia group, VAS scores at three days post-surgery were lower than those in the control group (P<0.01). The incidence of POCD on the third postoperative day was slightly lower in the pre-emptive analgesia group compared with the control group. In conclusion, the results demonstrate that pre-emptive analgesia by CFNB may promote the recovery of early cogni- tive function following TKA in elderly patients.

Experimental and Therapeutic Medicine published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Wong, Wi-Yeung published the artcileMultifunctional iridium complexes based on carbazole modules as highly efficient electrophosphors, Application In Synthesis of 57103-14-7, the publication is Angewandte Chemie, International Edition (2006), 45(46), 7800-7803, database is CAplus and MEDLINE.

Getting the green light: Highly efficient organic light-emitting diodes (OLEDs) have been synthesized from robust green-electrophosphorescent Ir^III complexes based on carbazole derivatives The combination of short triplet lifetime, high emission efficiency, and improved charge-transporting properties allows these OLEDs to achieve peak efficiencies of 12% photons per electron and 38 cdA^-1.

Angewandte Chemie, International Edition published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C9H9BrO2, Application In Synthesis of 57103-14-7.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

You, Zhensheng published the artcilePhosphinylation of Non-activated Aryl Fluorides through Nucleophilic Aromatic Substitution at the Boundary of Concerted and Stepwise Mechanisms, Related Products of isoxazole, the publication is Angewandte Chemie, International Edition (2021), 60(11), 5778-5782, database is CAplus and MEDLINE.

Non-activated aryl fluorides reacted with potassium diorganophosphinites through a nucleophilic aromatic substitution (S_NAr) reaction. Remarkably, both electron-neutral and electron-rich aryl fluorides participated in the reaction with substantially stabilized anionic P nucleophiles to form the corresponding tertiary phosphine oxides. Quantum chem. calculations suggested a nucleophile-dependent mechanism that involves both concerted and stepwise S_NAr reaction pathways.

Angewandte Chemie, International Edition published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C13H18BClO3, Related Products of isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem