Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21169-71-1,Isoxazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

Boc protected amine Ba (35 mg, 0.044 mmol) is charged in a vial, then a 4 M solution of HCI in dioxane (1 mL, 4 mmol) is added. The solution is stirred at RT for 2 h, after which a precipitate forms. The solution is evaporated to dryness. Acid R2o (6.5 mg, 0.057 mmol, 1 .30 equiv) is dissolved in DMF (0.5 mL), then TEA (30 mu, 0.22 mmol, 5.0 equiv) is added followed by TBTU (17 mg, 0.53 mmol, 1 .2 equiv). The solution is stirred for 15 mins, after which the amine hydrochloride Da is added in DMF (0.5 mL). This solution is stirred at RT for 16 h. Water (2 mL) is added and the organic layer is extracted with EtOAc (3 x 5 mL). The solvent is evaporated and the residue is purified on prep HPLC (MeCN:H20, 0.1 % TFA). The pure fractions are combined, concentrated, frozen and lyophilized to provide compound 1032. FIA M.S.(electrospray) : 793.4 (M+H)+ Retention time (min) = 5.6 min1H NMR (400 MHz,DMSO-d6): delta 11.03 (s, 1H), 9.13 (d, 1H, J = 6.6 Hz), 8.80 (s, 1H), 8.72 (d, 1H, J = 2.1 Hz), 7.86 (d, 1H, J = 9.1 Hz), 7.11 (d, 1H J = 2 Hz), 7.10 (d, 1H, J = 9.2 Hz), 6.36 (s, 1H), 5.67-5.59 (m, 1H), 5.55-5.44 (m, 2H), 5.14 (dd, 1H, J = 10.1, 8.7 Hz), 4.60-4.51 (m, 2H), 4.36 (dd, 1H, J = 9.9, 7.0 Hz), 4.01 (dd, 1H, J = 11.7, 3.5 Hz), 3.89 (s, 3H), 2.94-2.87 (m, 1H), 2.69-2.56 (m, 2H) , 2.44 (s, 3H), 2.41- 2.31 (m, 2H), 2.07-1.95 (m, 1H), 1.83-1.71 (m, 1H), 1.60-1.35 (m, 13H), 1.33-1.19 (m, 2H), 1.12-0.99 (m, 4H).

21169-71-1, The synthetic route of 21169-71-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LLINAS-BRUNET , Montse; BORDELEAU, Josee; GODBOUT, Cedrickx; LEBLANC, Melissa; MOREAU, Benoit; O’MEARA, Jeffrey; WO2011/63502; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14441-90-8,5-Phenylisoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

To a stirred suspension of LAH in THF (10 mL, 1M solution in THF) at 0 C. was added a solution of 5-phenylisoxazole-3-carboxylic acid (0.9 g in 5 mL of THF) and after completion of addition the reaction was slowly warmed to room temperature (30 min). The reaction mixture was cooled to 0 C. and ethyl acetate was added (30 mL), followed by slow addition of saturated sodium sulfate solution. The solid was rinsed with ether several times and the solvent decanted. The combined organic layer was dried over MgSO4, filtered and concentrated in vacuo to get (5-phenylisoxazol-3-yl)methanol (0.8 g, 96% yield)., 14441-90-8

14441-90-8 5-Phenylisoxazole-3-carboxylic acid 151916, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; VICURON PHARMACEUTICALS INC.; US2006/211603; (2006); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

7063-99-2, Ethyl 5-phenylisoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7063-99-2, A solution of phenyl-substituted isoxazole ethyl ester (53) (1.89 g, 8.70 mmol) in ethanol (30 mL) was stirred at room temperature. To this solution was added a 2 M NaOH solution (6.5 mL, 13.1 mmol). After 5 min, TLC showed that the reaction was complete. To the reaction mixture was added 0.5 M HCl to adjust the pH to 34, before extracting with ethyl acetate (2¡Á75 mL). The organic extracts were combined, washed with brine, dried over sodium sulfate, and concentrated to afford 5-phenyl-isoxazole-3-carboxylic acid (57) obtained as a white solid (1.54 g, 94%). 57: 1H NMR (500 MHz, CDCl3): delta 9.4 (broad, 1H), 7.83 (d, 2H), 7.51 (m, 3H), 6.99 (s, 1H)

7063-99-2 Ethyl 5-phenylisoxazole-3-carboxylate 571142, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Chapal, Nicolas; McNicol, Patricia; Jette, Lucie; US2006/223884; (2006); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

3405-77-4, 5-Methylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(Step 1) Production of ethyl 3-(5-methyl-isoxazol-3-yl)-3-oxo-propionate To a suspension of 5-methyl-isoxazole-3-carboxylic acid (2.78 g) in tetrahydrofuran (20 mL) was gradually added CDI (3.60 g). After stirring at room temperature for 30 minutes, the reaction mixture was heated on an oil bath to 60¡ã C. After 1 hour, the reaction mixture was cooled to room temperature, magnesium chloride (2.30 g) was added followed by addition of ethyl potassium malonate (4.50 g). After stirring at room temperature for 3 hours, water (15 mL) was added to the reaction mixture followed by addition of 6 N hydrochloric acid (5.0 mL). The reaction mixture was concentrated, and the produced solid was collected by filtration, washed with water, and dried to obtain the title compound (3.99 g) as a white solid., 3405-77-4

3405-77-4 5-Methylisoxazole-3-carboxylic acid 76947, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; JAPAN TOBACCO, INC.; US2009/36450; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3209-71-0,Isoxazole-3-carboxylic Acid,as a common compound, the synthetic route is as follows.

N-(2-(2-Phenylthiazol-4-yl)ethyl)isoxazole-3-carboxamide To a solution of the 2-(2-phenylthiazol-4-yl)ethan-1 -amine (80 mg, 0.39 mmol) in DMF (1 ml) was added the 1 ,2-oxazole-3-carboxylic acid (53 mg, 0.47 mmol), EDCI (91 mg, 0.47 mmol) and DMAP (5 mg, 0.04 mmol). The reaction mixture was stirred at 45 C for 18 h. Water (approximately 2 ml) was added to the reaction mixture and the product extracted with ethyl acetate (three times). The organic layers were combined and dried with magnesium sulphate. All of the volatiles were remove in vacuo and the crude material was purified by column chromatography, eluting with 10% ethyl acetate/petroleum spirit to obtain the desired product as a pale-orange oil (17 mg, 15%). LRMS [M+H]+ 300.1 m/z; HRMS [M+H]+ 300.0801 m/z, found 300.0802 m/z; 1 H NMR (400 MHz, DMSO) delta 9.08 (d, J = 1 .7 Hz, 1 H), 8.94 (t, J = 5.6 Hz, 1 H), 8.06 – 7.81 (m, 2H), 7.58 – 7.45 (m, 3H), 7.44 (s, 1 H), 6.88 (d, J = 1 .7 Hz, 1 H), 3.63 (dd, J = 13.1 , 7.2 Hz, 2H), 3.03 (t, J = 7.2 Hz, 2H).

3209-71-0, The synthetic route of 3209-71-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MONASH UNIVERSITY; THE UNIVERSITY OF WESTERN AUSTRALIA; BAELL, Jonathan; PIGGOTT, Matthew; RUSSELL, Stephanie; TOYNTON, Arthur; RAHMANI, Raphael; FERRINS, Lori; NGUYEN, Nghi; (178 pag.)WO2015/172196; (2015); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

51135-73-0,51135-73-0, Ethyl 5-methylisoxazole-4-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl-5-methylisoxazole-4-carboxylate 7 g (0.045 mol) was heated under reflux in aqueous sulphuric acid (20 % v/v, 30 ml) for 16 hr followed by cooling to room temperature with stirring for 4 h. The crystallized solid product was filtered and washed using toluene followed by water and dried. The product then was crystallized from ethanol to produce 3.5 g (60 %) of 5-Methylisoxazole-4-carboxylic acid as a white solid, mp. 147-148 C (reported mp. 144-147 C).

51135-73-0 Ethyl 5-methylisoxazole-4-carboxylate 7009317, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Hamdi, Abdelrahman; Said, Eman; Farahat, Abdelbasset A.; El-Bialy, Serry A.A.; Massoud, Mohammed A.M.; Letters in drug design and discovery; vol. 13; 9; (2016); p. 912 – 920;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59669-59-9,3-(tert-Butyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.

59669-59-9, C2a. Reaction of a Heterocyclic Amine with Phosgene to Form an Isocyanate, then Reaction with Substituted Aniline; Step 1. 3-tert-Butyl-5-isoxazolyl Isocyanate; To a solution of phosgene (20percent in toluene, 1.13 mL, 2.18 mmol) in CH2Cl2 (20 mL) at 0¡ã C. was added anh. pyridine (0.176 mL, 2.18 mmol), followed by 5-amino-3-tert-butylisoxazole (0.305 g, 2.18 mmol). The resulting solution was allowed to warm to room temp. over 1 h, and then was concentrated under reduced pressure. The solid residue dried in vacuo for 0.5 h.

The synthetic route of 59669-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Paulsen, Holger; Riedl, Bernd; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Hatoum-Mokdad, Holia; Johnson, Jeffrey; Lee, Wendy; Redman, Aniko; Sibley, Robert; Renick, Joel; US2007/244120; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

206055-91-6, (3-(4-Bromophenyl)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of (3-(4-bromophenyl)isoxazol-5-yl)methanol (AA; 0.5 g, 1.96 mmol) in CH2CI2 (15 mL) under inert atmosphere were added pyridine (0.39 mL, 4.91 mmol) and p- dimethylaminopyridine (0.024 mg, 0.19 mmol) at 0 C. After the addition of 4-nitrophenyl carbonochloridate (DK; 0.39 g, 1.93 mmol) at 0 C, the reaction mixture was warmed to RT and stirred for 12 h. The reaction was monitored by TLC. After complete consumption of the starting material, the reaction mixture was diluted with a saturated ammonium chloride solution (20 mL) and the compound was extracted with CH2CI2 (3×20 mL). The combined organic extracts were washed with water (20 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude. The crude was triturated with pentane (2×15 mL) to afford crude DL (710 mg) as an off-white solid. FontWeight=”Bold” FontSize=”10″ H NMR (500 MHz, CDCI3): delta 8.30 (d, / = 9.5 Hz, 2H), 8.17 (d, J = 6.8 Hz, 1H), 7.70-7.59 (m, 5H), 7.40 (d, J = 9.5 Hz, 2H), 6.91 (d, / = 9.0 Hz, 1H), 6.73 (s, 1H), 5.43 (s, 2H), 5.34 (s, 1H).

206055-91-6, 206055-91-6 (3-(4-Bromophenyl)isoxazol-5-yl)methanol 11032412, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; VIAMET PHARMACEUTICALS, INC.; HOEKSTRA, William, J.; YATES, Christopher, M.; RAFFERTY, Stephen, W.; WO2014/117090; (2014); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

131052-47-6, (3,5-Dimethylisoxazol-4-yl)methanamine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,131052-47-6

To a solution of [4-(3 ,4-dihydro- 1 H-isoquinoline-2-sulfonyl)-phenyl] -carbamic acid phenyl ester (370 mg, 0.9 mmoL), C-(3,5-dimethyl-isoxazol-4-yl)-methylamine (115 mg, 0.9 mmoL) and Et3N (0.3 mL, 2.1 mmoL) in MeCN (12 mL) at room temperature and stirred for lh at 80C. The reaction mixture was concentrated to dryness in vacuum and part of the residue (260 mg) was purified by Prep-HPLC to give 1- [4-(3 ,4-dihydro- 1 H-isoquinoline-2-sulfonyl)-phenyl] -3 -(3,5- dimethyl-isoxazol-4-ylmethyl)-urea (41 mg, yield: 10%) as a white solid. ?H NIVIR (300 IVIHz, DMSO-d6): oe = 8.95 (s, 1H), 7.68 (d, J= 8.7 Hz, 2H), 7.59 (d, J= 9.0 Hz, 2H), 7.15-7.11 (m, 4H), 6.67(t,J= 5.7Hz, 1H), 4.13 (s, 2H), 4.05 (d,J= 5.1 Hz, 2H), 3.23 (t,J 5.7 Hz, 2H), 2.84 (t,J4.8 Hz, 2H), 2.37 (s, 3H), 2.20 (s, 3H). MS: m/z 441.0 (M+H).

131052-47-6 (3,5-Dimethylisoxazol-4-yl)methanamine 11018874, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7063-99-2,Ethyl 5-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.,7063-99-2

Synthesis of 5-phenyl-isoxazole-3-carboxylic acid (57) A solution of phenyl-substituted isoxazole ethyl ester (53) (1.89 g, 8.70 mmol) in ethanol (30 mL) was stirred at room temperature. To this solution was added a 2M NaOH solution (6.5 mL, 13.1 mmol). After 5 min. TLC showed that the reaction was complete. To the reaction mixture was added 0.5M HCl to adjust the pH to 3-4, before extracting with ethyl acetate (2¡Á75 mL). The organic extracts were combined, washed with brine, dried over sodium sulfate, and concentrated to afford 5-phenyl-isoxazole-3-carboxylic acid (57) was obtained as a white solid (1.54 g, 94%). 57: 1H NMR (500 MHz, CDCl3): delta 9.4 (broad, 1H), 7.83 (d, 2H), 7.51 (m, 3H), 6.99 (s, 1H)

The synthetic route of 7063-99-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mioskowski, Charles; Marin, Sandra De Lamo; Maruani, Martine; Gill, Manjinder; US2006/199853; (2006); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem