Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3209-71-0,Isoxazole-3-carboxylic Acid,as a common compound, the synthetic route is as follows.

a) Ethyl 5-(isoxazol-3-yl)-1,2,4-oxadiazole-3-carboxylate Ethyl aminohydroxyiminoacetate (3.78 mmol, 0.5 g), 3-isoxazolecarboxylic acid (3.78 mmol, 0.428 g) and 1,3-diisopropylcarbodiimide (4.16 mmol, 0.525 g) were dissolved in DCM (70 ml) under nitrogen atmosphere. The mixture was stirred at RT for a day. The solvent was evaporated to dryness and the residue was dissolved in pyridine and refluxed for 6 h and overnight at RT. Pyridine was evaporated and the residue was diluted with DCM and water. The aqueous phase was extracted four times with DCM. The combined organics were washed with aqueous HCl solution, saturated NaHCO3, water and brine. The organic phase was dried, filtered and evaporated. The crude product was purified by flash chromatography. 0.396 g of the title compound was obtained. Rotamers were obtained in 1H-NMR and analysis was repeated at elevated temperature. 1H-NMR (400 MHz, DMSO-d6, +60 C.): delta 1.38 (t, 3H), 4.49 (q, 2H), 7.21 (d, 1H), 9.05 (d, 1H).

3209-71-0, As the paragraph descriping shows that 3209-71-0 is playing an increasingly important role.

Reference£º
Patent; ORION CORPORATION; Toermakaengas, Olli; Wohlfahrt, Gerd; Salo, Harri; Ramasurbamanian, Rathna Durga; Patra, Pranab Kumar; Martin, Arputharaj Ebenezer; Heikkinen, Terhi; Vesalainen, Anniina; Moilanen, Anu; Karjalainen, Arja; US2014/94474; (2014); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.300-87-8,3,5-Dimethylisoxazole,as a common compound, the synthetic route is as follows.

Intermediate 1 : 4-iodo-3,5-Dimethylisoxazole; Nitric acid (13ml) was added dropwise (exothermic reaction) to a mixture of 3,5- dimethylisoxazole (31.3g, 320mmol) and iodine (37.3g, 150 mmol) and the mixture was stirred at room temperature for 1 h. The reaction mixture was hydrolysed with a mixture of ice and water and extracted with DCM. The organic phase was washed with a solution of Na2S203, dried over Na2S04 and concentrated under reduced pressure to afford the title compound as a yellow solid (60g, 83%). [APCI MS] m/z: 224 MH+, Rt 2.17min., 300-87-8

The synthetic route of 300-87-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE LLC; BOUILLOT, Anne, Marie, Jeanne; DONCHE, Frederic; GELLIBERT, Francoise, Jeanne; LAMOTTE, Yann; MIRGUET, Olivier; WO2011/54846; (2011); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

2510-36-3, 3,5-Dimethylisoxasole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3,5-dimethylisoxazole-4-carboxylic acid (0.3 mmol), oxalyl chloride (125 ? ) and catalytic amount of DMF was stirred at room temperature for 2h. After evaporating to dryness, the residual crude acid chloride was dissolved in 2 mL DCM. To the solution was added 3 (26 mg, 0.1 mmol) and DIEA (52 ??^). After stirring overnight at room temperature, the reaction mixture was worked up with aq. NaHCOs/DCM. DCM phase was washed with brine and concentrated to dryness. The residue was dissolved in 2 mL THF/MeOH/H20 (5:4: 1) and stirred with IN NaOH (100 ??) at room temperature for 2h before worked up with EA/ aq. NaHC03. Silica gel flash chromatography furnished (3,5-dimethylisoxazol-4-yl)-N-{3-fluoro-4- [l-methyl-3-(trifluoromethyl)pyrazol-5-yl]phenyl}carboxamide 92 (16 mg, yield: 41.9%, purity >95%) as a colorless gel. MS (ESI) [M+H]+ 383.1., 2510-36-3

The synthetic route of 2510-36-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CALCIMEDICA, INC.; CAO, Jianguo; WHITTEN, Jeffrey, P.; WANG, Zhijun; ROGERS, Evan; GREY, Jonathan; WO2013/59666; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35166-33-7,3-Hydroxymethyl-5-methylisoxazole,as a common compound, the synthetic route is as follows.

Example 253 (5-Methyl-3-isoxazolyl)methyl N-[4-(4-amino-7-tetrahydro-2H-4-pyranyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]carbamate Phenyl N-[4-(4-amino-7-tetrahydro-2H-4-pyranyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]carbamate (30 mg, 0.065 mmol) was mixed with (5-methyl-3-isoxazolyl)methanol (0.05 mL) in pyridine (0.5 mL). The reaction mixture was heated at 100 C. overnight. The solvent was removed and the residue was purified by preparative reverse phase LC/MS to give (5-methyl-3-isoxazolyl)methyl N-[4-(4-amino-7-tetrahydro-2H-4-pyranyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]carbamate (18 mg, 0.038 mmol). 1H NMR (CDCl-d) delta2.06(m, 4H), 2.44 (s, 3H), 3.64 (m, 2H), 3.91 (s, 3H), 4.13 (m, 2H), 4.96 (m, 1H), 5.26 (s, 2H), 6.12(s, 1H), 6.95 (s, 1H), 7.06 (m, 2H), 7.39 (s, 1H), 8.17 (bs, 1H), 8.21(s, 1H). LC/MS: MH+479., 35166-33-7

As the paragraph descriping shows that 35166-33-7 is playing an increasingly important role.

Reference£º
Patent; Hirst, Gavin C.; Calderwood, David; Munschauer, Rainer; Arnold, Lee D.; Johnston, David N.; Rafferty, Paul; US2003/153752; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

91182-60-4, 5-(4-Bromophenyl)-3-methylisoxazole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,91182-60-4

Step 2: [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid (R)-l-phenyl-ethyl ester[00483] 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid (25g, 88.7mmol) in toluene (500mL) was added triethylamine (18.5mL, 133mmol), followed by diphenylphosphoryl azide (22.1mL, 101.9mmol). (R)-(+)- 1 -Phenylethyl alcohol (11.9mL, 97.5mmol) was added, and the reaction was stirred at 75C for 2 hours. The mixture was partitioned between EtOAc and H 0 and filtered through Celite. The aqueous layer was extracted with EtOAc, and the combined organic layers were dried over MgS04, filtered, and concentrated to give the title compound.

The synthetic route of 91182-60-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMIDRA PHARMACEUTICALS, INC.; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; KING, Christopher, David; WO2011/159550; (2011); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88511-37-9,1-(Isoxazol-3-yl)ethanone,as a common compound, the synthetic route is as follows.,88511-37-9

General procedure: To a solution of ketone A in THF cooled to -78 C, LiHMDS (e.g., 0.9 eq, 1.0 M in toluene) is added dropwise, for example using a syringe. The reaction mixture is then allowed to warm to about 0 C, then charged with diethyl oxalate (1.2 eq). At this time, the reaction mixture is warmed to room temperature and stirred at that temperature until judged complete (e.g., using either TLC or LC/MS analysis). Once the reaction is complete (reaction time typically about 45 minutes), the product dione enolate B is used as-is in Step 2, i.e., the cyclization step, without any further purification

The synthetic route of 88511-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IRONWOOD PHARMACEUTICALS, INC.; IM, G-Yoon, Jamie; IYENGAR, Rajesh; MOORE, Joel; FRETZEN, Angelika; WO2014/47111; (2014); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91182-60-4,5-(4-Bromophenyl)-3-methylisoxazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

91182-60-4, 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid (2.Og, 7.09mmol) and triethylamine (0.99mL, 7.09mmol) were dissolved in toluene (5OmL). Diphenylphosphoryl azide (1.5mL, 7.09mmol) was added, followed by (R)-(+)-l- phenylethyl alcohol (0.865g, 7.09mmol; commercially available or prepared using procedures desribed herein or in the literature: e.g. E.J. Corey et al. J. Am. Chem. 1987, 109, 5551-5553), and the reaction was stirred at 8O0C for 4 hours. The mixture was concentrated, and the residue was purified by silica gel chromatography to give the title compound.

As the paragraph descriping shows that 91182-60-4 is playing an increasingly important role.

Reference£º
Patent; AMIRA PHARMACEUTICALS, INC.; HUTCHINSON, John Howard; SEIDERS, Thomas Jon; WANG, Bowei; ARRUDA, Jeannie M.; ROPPE, Jeffrey Roger; PARR, Timothy; WO2010/141761; (2010); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

Reference Production Example 195 (0838) Methanesulfonyl-chloride (5.42 mL, 38.90 mmol) was added to a chloroform solution (amylene addition product, 100 mL) of ethyl 5-hydroxymethylisoxazole-3-carboxylate (5.12 g, 29.92 mmol) and triethylamine (2.66 mL, 34.40 mmol) under ice-water cooling, and the mixture was stirred at room temperature or lower for 2 hours. Then, the mixture was poured into ice water, and extracted twice with chloroform. The organic layer was washed with saturated saline water, dried over magnesium sulfate and then concentrated under reduced pressure, and the residue was applied to a silica gel column chromatography to obtain 6.02 g of ethyl 5-methanesulfonyloxymethylisoxazole-3-carboxylate represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.43(3H, t)3.09(3H, s), 4.46(2H, q), 5.36(2H, s), 6.87(1H, s)., 123770-62-7

The synthetic route of 123770-62-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

7063-99-2, Ethyl 5-phenylisoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7063-99-2, General procedure: To a stirred mixture of NaBH4 (3 equiv), 1a-e or 13a-u (1 equiv) in reflux anhydrous THF (20 ml) was added MeOH (1ml). After refluxing for futher 30 min, the reaction mixture was pouring into ice water (10 ml), and extracted with ethyl acetate (3 ¡Á 15 mL), the organic fractions were combined, washed with saturated brine (2 ¡Á 15 ml) prior to drying over anhydrous Na2SO4. After filtration and concentrate using a rotary evaporator,the residual white solid in thenext step without further purification. To a solution of the obtained solid (1 equiv) indichloromethane (20 ml) was slowly added thionyl chloride (6 equiv) and a catalytic amount of DMF at room temperature. After stirring at 40 C for 4 h, the reaction was concentrated under reduced pressure. The residue was purified by silica gel column chromatography using a mixture of petroleum ether/ethyl acetate (20:1, v/v) aseluent to afford the desired product.

The synthetic route of 7063-99-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Zheng; Qiu, Qianqian; Xu, Xue; Wang, Xuekun; Jiao, Lei; Su, Xin; Pan, Miaobo; Huang, Wenlong; Qian, Hai; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 246 – 257;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.100499-66-9,5-Methylisoxazol-4-amine hydrochloride,as a common compound, the synthetic route is as follows.

The following compounds were prepared using procedures analogous to those described in JOC 1987,2714-2726.

100499-66-9, 100499-66-9 5-Methylisoxazol-4-amine hydrochloride 13033203, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/76435; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem