Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-37-5,4-(Chloromethyl)-3,5-dimethylisoxazole,as a common compound, the synthetic route is as follows.

General procedure: The corresponding alkyl halide reagent (1mmol) was added to a mixture of selenourea (1.1mmol) (compounds 1a-j) or thiourea (compounds 2a-j) in absolute ethanol (20mL). The mixture was stirred at reflux, room temperature or 0C for 0.5-6h. The product was isolated by filtration or by rotatory evaporation of the solvent under vacuum and purified by recrystallization or washing. 4.1.11 (3,5-Dimethylisoxazol-4-yl)methyl carbamimidoselenoate hydrochloride (1i); Conditions: 2.5 h at reflux. After this time, the mixture was filtered and the solvent was removed under vacuum by rotatory evaporation. The brown powder was washed with acetone (25mL). Yield: 76%; mp: 168-170C. 1H NMR (400MHz, DMSO-d6): delta 2.23 (s, 3H, C3-CH3), 2.40 (s, 3H, C5-CH3), 4.41 (s, 2H, -CH2-), 9.50ppm (bs, 4H, NH2+NH+HCl). 13C NMR (100MHz, DMSO-d6): delta 10.7 ((C5)-CH3), 11.8 ((C3)-CH3), 19.5 (-CH2-), 110.6 (C4), 160.1 (C5), 166.5 (C3), 167.7ppm (Se-C-(NH)(NH2)). IR (KBr): nu 3220-3100 (s; N-H, N-H2), 1655cm-1(s, C=N). MS (m/z (% abundance)): 228(13), 213(22), 190(24), 156(43), 110(98), 68(100), 43(100). Elemental analysis calculated (%) for C7H11N3OSe HCl: C: 31.30, H: 4.50, N: 15.64; found: C: 30.94, H: 4.59, N: 15.53.

19788-37-5, As the paragraph descriping shows that 19788-37-5 is playing an increasingly important role.

Reference£º
Article; Alcolea, Veronica; Plano, Daniel; Karelia, Deepkamal N.; Palop, Juan Antonio; Amin, Shantu; Sanmartin, Carmen; Sharma, Arun K.; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 134 – 144;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51135-73-0,Ethyl 5-methylisoxazole-4-carboxylate,as a common compound, the synthetic route is as follows.

51135-73-0, EXAMPLE 4 Preparation of 5-Methylisoxazole-4-Carboxylic Acid A two-necked flask fitted with mechanical stirrer and a horizontal condenser for distillation was charged with 40.0 g of crude Ethyl-5-methylisoxazole-4-carboxylate and 44 g of 60% sulfuric acid and the mixture was heated to 85 C. with continuous distillation of ethanol from the reaction product. After four hours of heating at 85 C., TLC showed the complete disappearance of the upper spot of ester. The mixture was allowed to cool in the refrigerator and the solid acid was filtered (16.5 g) Filtrate kept at room temperature for second crop. Acid was crystallized in 60 mL 2% acetic acid-Toluene to obtain about 99.9% pure acid (9.5 g). Mother liquor of the final crystallization was kept for second crop. Crystallization was accomplished by: The crude acid was taken in 2% acetic acid-toluene mixture and heated for 30 minutes. Brown oil was separated at the bottom of the flask. The clear organic phase was neatly transferred and kept for crystallization.

The synthetic route of 51135-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ray, Anup Kumar; Patel, Hiren Kumar V.; Patel, Mahendra R.; US2003/139606; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-37-5,4-(Chloromethyl)-3,5-dimethylisoxazole,as a common compound, the synthetic route is as follows.

Example 10-39a 2-((3,5-dimethylisoxazol-4-yl)methyl)-2H-tetrazol-5-amine 2H-tetrazol-5-amine (1.29 g, 12.5 mmol), 4-(chloromethyl)-3,5-dimethylisoxazole (1.56 mL, 12.5 mmol) and potassium carbonate (1.73 g, 15.5 mmol) in DMF (20 mL) were heated to 80 C. with stirring for 16 hours. The reaction was cooled to room temperature, diluted with dichloromethane (100 mL) and washed consecutively with brine and water. The organics were dried over sodium sulfate and concentrated with rotary evaporation. The crude product was purified by silica gel chromatography (0-10% gradient ethyl acetate/dichloromethane) affording 2-((3,5-dimethylisoxazol-4-yl)methyl)-2H-tetrazol-5-amine as a white crystalline solid (970 mg, 40% yield) MS M+H calculated 195.1, found 195., 19788-37-5

As the paragraph descriping shows that 19788-37-5 is playing an increasingly important role.

Reference£º
Patent; Senomyx, Inc.; US2009/274632; (2009); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-37-5,4-(Chloromethyl)-3,5-dimethylisoxazole,as a common compound, the synthetic route is as follows.

5-ethyl-6-methyl-4-phenylthieno[2,3-d] pyrimidin-2(1H)-one (2a,2 g, 7.4 mmol) and 4-(chloromethyl)-3,5-dimethylisoxazole (0.94 mL,8.9 mmol) were put into 100 mL round bottom flask, then 50 mL dimethylsulfoxide as solvent and 0.1 g potassium carbonate used ascatalyst for the reaction were added. The reaction mixture was heatedat 110 C for 1.5 h. The reaction mixture was then diluted with 100 mLdichloromethane and washed with brine (50 mL¡Á3). The organicsolvent was removed under vacuum. The residue dissolved in ethylacetate and purified with silica gel column chromatography (producteluted at 100% [v/v] ethyl acetate/petroleum ether) to afford 1-((3,5-dimethylisoxazol-4-yl)methyl)-5-ethyl-6-methyl-4-phenylthieno[2,3-d]pyrimidin-2(1H)-one (3a) as a yellow crystal.

19788-37-5, 19788-37-5 4-(Chloromethyl)-3,5-dimethylisoxazole 88246, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Ma, Junlong; Chen, Heng; Yang, Jie; Yu, Zutao; Huang, Pan; Yang, Haofeng; Zheng, Bifeng; Liu, Rangru; Li, Qianbin; Hu, Gaoyun; Chen, Zhuo; Bioorganic and Medicinal Chemistry; vol. 27; 9; (2019); p. 1871 – 1881;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4,62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 124 5-(isoxazol-5-oyl)amino-3-(1-methylpiperidin-4-yl)-1H-indole Beginning with 13 mg (0.056 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 8.21 mg (0.062 mMol) isoxazole-5-carbonyl chloride, 10.4 mg (57%) of the title compound were recovered. MS(m/e): 325(M+)

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; EP832650; (1998); A2;; ; Patent; ELI LILLY AND COMPANY; EP824917; (1998); A2;; ; Patent; Eli Lilly and Company; US5708008; (1998); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

123770-62-7, Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Production Example 208 (0851) Ethyl 5-hydroxymethylisoxazole-3-carboxylate (1.71 g, 10.0 mmol) was dissolved in tetrahydrofuran (50 mL), and 3,5-difluorobenzyl bromide (2.48 g, 12.0 mmol) and 18-crown-6 (0.26 g, 1.0 mmol) were added thereto. Sodium hydride (60% oil-based) (0.80 g, 20.0 mmol) was slowly added thereto at room temperature, and the mixture was stirred at room temperature overnight. Then, dilute hydrochloric acid was added thereto, and the mixture was extracted three times with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was dissolved in ethanol (20 mL), and an aqueous solution obtained by dissolving potassium hydroxide (2.81 g, 50 mmol) in water (10 mL) was added thereto at room temperature, and then the mixture was stirred at 80C for 3 hours. Water was added to the reaction mixture, and the mixture was concentrated under reduced pressure. Tert-butyl methyl ether was added to the concentrate, and the aqueous layer was fractionated. Dilute hydrochloric acid was added to the resulting aqueous layer, and the mixture was extracted three times with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure to obtain 1.38 g of 5-(3,5-difluorobenzyloxymethyl)isoxazole-3-carboxylic acid represented by the following formula. The product was subjected to a next reaction without purification., 123770-62-7

As the paragraph descriping shows that 123770-62-7 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19788-37-5,4-(Chloromethyl)-3,5-dimethylisoxazole,as a common compound, the synthetic route is as follows.

To a solution of the product of Example 1B (120 mg, 0.40 mmol) in tetrahydrofuran (3 mL) at 0 C. was added NaH (95 weight %, 31 mg, 1.22 mmol). The mixture was allowed to warm to ambient temperature and 4-(chloromethyl)-3,5-dimethylisoxazole (88 mg, 0.61 mmol) was added. The resulting mixture was stirred at ambient temperature for 18 hours. The reaction was quenched with water (0.5 mL) and concentrated in vacuo. The residue was dissolved in a solvent mixture of dimethyl sulfoxide (3 mL), methanol (2 mL) and water (0.5 mL), filtered through a glass microfiber frit and purified by preparative HPLC [Waters XBridge C18 5 mum column, 50*100 mm, flow rate 90 mL/minute, 5-95% gradient of acetonitrile in buffer (0.025 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide)] to give the titled compound (155 mg, 0.38 mmol, 94% yield). 1H NMR (400 MHz, methanol-d4) delta ppm 8.38 (s, 1H), 7.61 (td, J=7.7, 1.6 Hz, 1H), 7.58-7.51 (m, 1H), 7.49-7.34 (m, 3H), 7.13 (dd, J=8.5, 2.9 Hz, 1H), 7.10 (d, J=7.5 Hz, 1H), 4.36 (s, 2H), 4.12-3.94 (m, 2H), 3.58-3.43 (m, 2H), 2.46 (s, 3H), 2.31 (s, 3H); MS (ESI+) m/z 406 [M+H]+., 19788-37-5

19788-37-5 4-(Chloromethyl)-3,5-dimethylisoxazole 88246, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; AbbVie Inc.; Daanen, Jerome F.; DeGoey, David A.; Frost, Jennifer M.; Koenig, John R.; Latshaw, Steve; Matulenko, Mark; Scanio, Marc; Shi, Lei; Bunnelle, William H.; (128 pag.)US2016/75692; (2016); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

35166-33-7, 3-Hydroxymethyl-5-methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(c) 3-Chloromethyl-5-methylisoxazole A solution of 3-hydroxymethyl-5-methyl isoxazole (6.50 g, 57.5 mmol) and triphenylphosphine (15.1 g, 57.5 mmol) in carbon tetrachloride (120 ml) were heated at reflux in 18 h. Solvent was removed from the cooled mixture under reduced pressure then the residue taken up in ether and filtered. The filtrate was concentrated under reduced pressure then flash chromatographed through silica using 1:1 ether: 40-60 C. petroleum ether fraction as eluant to give 3-chloromethyl-5-methylisoxazole (5.43 g, 41.3 mmol, 72%); numax (film) 3130, 2960, 2920, 1610, 1475, 1400, 1270, 1250, 1160, 1130, 1010, 920, 890, 800, 750 cm-1; deltaH (CDCl3) 2.40 (3H, s, CH3 -5), 4.55 (2H, s, CH2 –Cl), 6.10 (1H, s, CH-4).

35166-33-7, 35166-33-7 3-Hydroxymethyl-5-methylisoxazole 2736567, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Patent; Beecham Group p.l.c.; US4812470; (1989); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

3356-94-3, Ethyl 5-chloro-3-methylisoxazole-4-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0863] to a mixture of compound 139b (400 mg, 2.1 mmol) and 2h-indazole (299 mg, 2.5 mmol) in DMF(3 ml) was added K2CO3 (1.2 g, 8.4 mmol) in one portion. The mixture was stirred at 80 C for 12 hours. Then H2O (9ml) was added into the mixture, and the aqueous phase was extracted with EtOAc (15 ml x 3), and the combined organic layer was concentrated to give a residue. The residue was purified by column chromatography (SiO2, petroleum ether: ethyl acetate = 300: 1 to 40: 1) to give compound 139c (340 mg, yield: 59.4%) as a pale yellow solid. 1H NMR (400mhz, CDCl3) s 8.33 (s, 1h), 7.82 (d, = 7.9 hz, 1h), 7.68 (d, = 8.8 hz, 1h), 7.57 – 7.51 (m, 1h), 7.35 (t, j = 7.7 hz, 1h), 4.24 (q, j = 7.0 hz, 2h), 2.56 (s, 3h), 1.13 (t, = 7.2 hz, 3h).

3356-94-3, As the paragraph descriping shows that 3356-94-3 is playing an increasingly important role.

Reference£º
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

54593-26-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54593-26-9,3,5-Dimethyl-4-isoxazolecarbaldehyde,as a common compound, the synthetic route is as follows.

[000298] 4-Piperidinone (0.92 gr, 6 mmol) was placed in a 25 ml round bottom flask and cooled to 0 C. Boron trifluoride (10 mL) was added dropwise followed by the aldehyde (1.5 gr, 12 mmol) in one portion. The reaction mixture was stirred overnight at room temperature under nitrogen atmosphere. The reaction was carefully quenched with a saturated solution of NaHCC . The solid precipitated out from the solution was filtered under reduced pressure, washed with water and EtOH to give the intermediate El-1 (Scheme 7) as a yellow solid (1.2 gr, 3.8 mmol, 63%).

As the paragraph descriping shows that 54593-26-9 is playing an increasingly important role.

Reference£º
Patent; PI THERAPEUTICS LTD.; KALID, Ori; GOTLIV, Irina; LEVY-APTER, Einat; FINKELSHTEIN BEKER, Danit; JAGTAP, Prakash; (0 pag.)WO2019/171379; (2019); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem