Tag: M.W:0-100

1072-67-9, 5-Methylisoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 45 N-isoxazolyl enaminone 1 (1.0mmol, 0.800g), aryl glyoxal monohydrates 2 (1.0mmol, 0.552g) and 4-amino-3-methyl-5-styrylisoxazoles 320h,23 (1.0mmol, 0.727g) in 4.5mL 46 water and 18 AcOH 0.5mL was refluxed at 100C for 1h. After completion of the reaction (monitored by TLC), the mixture was cooled to room temperature and poured into ice-cold water. The precipitate that formed was filtered off, washed with ice cold water and the crude product was purified by recrystallization from methanol to give pure bis-isoxazolyl amino dihydro-1H-indol-4(5H)-ones 42 4., 1072-67-9

As the paragraph descriping shows that 1072-67-9 is playing an increasingly important role.

Reference£º
Article; Nagi Reddy, Modugu; Praveen Kumar, Pittala; Tetrahedron Letters; vol. 58; 51; (2017); p. 4790 – 4795;,
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1750-42-1, Isoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 1 mmol aldehyde, 3 volume of acetonitrile and 1 equivalent volume of aminewere added to 0.6 equivalent of quinoline derivatives and 1% (v/v) formic acid. The reaction mixturewas stirred at higher temperature (75 C). The reaction was monitored by TLC (eluent: hexaneisomeric mixture:acetone). If the product precipitated, it was filtered, washed with hexane, and dried.If the reaction mixture was homogeneous, it was evaporated to dryness and was purified by columnchromatography (eluent: hexane:acetone from 20:1 to 4:1, v/v). The crude product was crystallizedfrom hexane/ethyl-acetate. The molecular structures were determined by means of 1D and 2D-NMRtechnologies (see Supplementary Materials), 1750-42-1

Big data shows that 1750-42-1 is playing an increasingly important role.

Reference£º
Article; Kanizsai, Ivan; Madacsi, Ramona; Hackler, Laszlo; Gyuris, Mario; Szebeni, Gabor J.; Huzian, Orsolya; Puskas, Laszlo G.; Molecules; vol. 23; 8; (2018);,
Isoxazole – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.

3-amino-5-methylisooxazole (326 mg, 3.3 mmol) was dissolved in dichloromethane (6.5 mL), and ice-cooled. Thiophosgene (0.278 mL, 3.3×1.1 mmol) and sodium carbonate aqueous solution (769 mg, 3.3×2.2 mmol, 4 mL) were added, and stirred at room temperature for 2.5 hours. After the reaction, chloroform was added and washed with the saturated sodium chloride solution, dried with magnesium sulfate and the solvent was distilled off. The obtained residue was purified by Silica gel column chromatography (Biotage Isolera One, SANP 10 g, chloroform/methanol)to obtain title compound (yellow oil, 255 mg, 55.1%) ., 1072-67-9

As the paragraph descriping shows that 1072-67-9 is playing an increasingly important role.

Reference£º
Patent; CHIBA UNIVERSITY; YAKULTHONSHA COMPANY LIMITED; TAKAYAMA, HIROMITSU; YASOBU, NAOKO; KITAJIMA, MARIKO; YAEGASHI, TAKASHI; MATSUZAKI, TAKESHI; NAGAOKA, MASATO; HASHIMOTO, SHUSUKE; NISHIYAMA, HIROYUKI; SUGIMOTO, TAKUYA; ONO, MASAHIRO; (176 pag.)JP5829520; (2015); B2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14678-02-5,5-Amino-3-methylisoxazole,as a common compound, the synthetic route is as follows.

General procedure: To 4-amino-3-methyl-5-styrylisoxazoles 7 [18h,20] (1.0 mmol, 0.750 g) in 0.5 mL of AcOH and 4.5 mL of water, dimedone 8 (1.0 mmol, 0.525 g) was added and the reaction mixture refluxed at 100 C for 10 min, followed by the addition of aryl glyoxal monohydrates 9 (1.0 mmol, 0.569 g) and 5-amino-3-methylisoxazole 10 (1 mmol, 0.367 g) and the reaction continued for another 50 min. After completion of the reaction (monitored by TLC), the mixture was cooled to room temperature and poured into ice-cold water. The precipitate that formed was filtered off, washed with ice cold water and the crude product was purified by recrystallization from methanol to give pure bis-isoxazolopyrroloquinolines 11.

14678-02-5, 14678-02-5 5-Amino-3-methylisoxazole 84590, aIsoxazoles compound, is more and more widely used in various fields.

Reference£º
Article; Rayudu, Sri Venkateswarlu; Karmakar, Dipankar; Kumar, Pramod; Tetrahedron Letters; vol. 60; 36; (2019);,
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14678-02-5, 5-Amino-3-methylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) N-(3-methyl-5-isoxazolyl)-4-bromobenzenesulfonamide 4-brombenzenesulfonyl chloride (solid) was added, in five portions, to a solution of 3-methyl-5-aminoisoxazole (3.82 g, 40 mmol) in dry pyridine (30 ml). This was stirred at room temperature for 3 h and the pyridine was removed under reduced pressure. The residue was dissolved in THF (300 ml) and a 5% NaOH solution (100 ml) was added. Stirring continued for 1 h at room temperature. The THF was removed under reduced pressure and the resultant residue was neutralized to pH 2 using concentrated hydrochloric acid. This was extracted with ethyl acetate (3*200 ml) and the combined organic layer was dried over MgSO4 and concentrated. The crude product was recrystallized using hexane/ethyl acetate giving N-(3-methyl-5-isoxazolyl)-4-bromobenzenesulfonamide (9.2 g, 72% yield).

14678-02-5, The synthetic route of 14678-02-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chan, Ming Fai; Kogan, Timothy; Verner, Erik Joel; Kois, Adam; Balaji, Vitukudi Narayanaiyengar; US2002/95041; (2002); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98019-60-4,Isoxazol-5-ylmethanol,as a common compound, the synthetic route is as follows.

98019-60-4, Step 2Isoxazole-5-carbaldehydeIn a round-bottomed flask, isoxazol-5-yl-methanol (511 mg, 5.16 mmol) was dissolved in dichloromethane (30 ml). Dess-Martin periodinane (2.3 g, 5.41 mmol) was added and the reaction mixture was stirred at room temperature for 1.5 h. The reaction was quenched with 50 ml of a 1 :1 solution of 10%> aqueous Na2S203 and saturated aqueous NaHCC>3 and then extracted with dichloromethane (2x). The organic layers were washed with saturated aqueous NaHCC>3, water and brine. The aqueous layers were back extracted with dichloromethane. The organic layers were combined, dried over sodium sulfate, filtered and concentrated. The residue was chromato graphed over silica gel with EtOAc/hexanes (gradient 0-40% EtOAc) to afford 226 mg (45%) of isoxazole-5-carbaldehyde as a colorless oil. 1H NMR (CDC13, 300 MHz): ? (ppm)10.05 (s, 1H), 8.44 (d, J=1.9 Hz, 1H), 7.02 (d, J=1.9 Hz, 1H).

As the paragraph descriping shows that 98019-60-4 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Shaoqing; DE VICENTE FIDALGO, Javier; HAMILTON, Matthew Michael; HERMANN, Johannes Cornelius; KENNEDY-SMITH, Joshua; LI, Hongju; LOVEY, Allen John; LUCAS, Matthew C.; LUK, Kin-Chun Thomas; LYNCH, Stephen M.; O’YANG, Counde; PADILLA, Fernando; SCHOENFELD, Ryan Craig; SIDDURI, Achyutharao; SOTH, Michael; WANG, Ce; WOVKULICH, Peter Michael; ZHANG, Xiaohu; WO2013/30138; (2013); A1;,
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87988-94-1, 5-Methylisoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

87988-94-1, To a stirred slurry of 4-methyl-3-[6-(4-methylpiperazm-l-yl)-4-oxoquinazolin-3(4H)-yl]benzoic acid (0.38 g) in DMF (50 ml) was added 4-amino-5-methylisoxazole hydrochloride (0.27 g), EtaATU (0.68 g) and triethylamine (0.55 ml) and the reaction mixture stirred at room temperature for 16 hours. The reaction mixture was diluted with water and extarcted with ethyl acetate. The ethyl aceate layer was washed with IN NaOH and dried (magnesium sulphate). The residue was purified by column chromatography on a silica column using initially ethyl acetate and then a 4: 1 mixture of ethyl acetate and methanol as eluent. There was thus obtained the title compound (150 mg); NMR Spectrum: (DMSOd6) 2.15 (s, 3Eta), 2.40 (s, 3H), 2.83 (m, 4H), 3.15 (s, 3H), 3.40 (m, 4H), 7.50 (d, IH), 7.60 (d, IH), 7.64 (m, 2H), 7.98 (s, IH), 8.04 (d, IH), 8.13 (s, IH), 8.70 (s, IH), 10.10 (s, IH); Mass Spectrum: M+H+ 459.The 4-amino-5-methylisoxazole hydrochloride used as starting material was prepared using the procedures detailed in J. Org. Chem 1987, 2714-2716.

As the paragraph descriping shows that 87988-94-1 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/90143; (2006); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87988-94-1,5-Methylisoxazol-4-amine,as a common compound, the synthetic route is as follows.

87988-94-1, A mixture of 2-{[(4-f.uorop enyl)methyl]oxy}-5-(1-methyl-1 H-pyrazol-4-yl)benzoic acid (may be prepared as described in Description 121 ; 80 mg, 0.25 mmol), 3- methylisoxazol-4-amine (49.5 mg, 0.37 mmol), HOBT (56.3 mg, 0.37 mmol) and EDC (70.5 mg, 0.37 mmol) in N,N-dimethylformamide (2 ml) was stirred at room temperature for 16 hours. Water (50 ml) was added. A white precipitate was filtered, washed with ethyl acetate, and dried in vacuo to yield the title compound as a white solid. 54 mg, 1HNMR (400 MHz, DMSO-c 6): 1 .99 (3H, s), 3.86 (3 H, s), 5.25 (2 H, s), 7.25 (2H, t, J= 8.8 Hz), 7.32 (2H, d, J = 8.4 HZ), 7.59-7.62 ( H, q, J = 2.8, J = 8.8), 7.73-7.75 ( H, dd, J = 2.4 Hz, J = 8.4 Hz), 7.88 (1 H, s), 7.92 (1 H, d, J = 2.4), 8.16 (1 H, s), 9.17 (1 H, s), 9.88 (1 H, s)MS (electrospray): m/z [M+H]+ =407.1

As the paragraph descriping shows that 87988-94-1 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; NICHOLS, Paula Louise; EATHERTON, Andrew John; BAMBOROUGH, Paul; JANDU, Karamjit Singh; PHILPS, Oliver James; ANDREOTTI, Daniele; WO2011/38572; (2011); A1;,
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16401-14-2, Isoxazole-5-carbaldehyde is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 91 7-Bromo-2-isoxazol-5-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine The title compound, MS m/e (%): 280 (M+, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and isoxazole-5-carbaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

16401-14-2, As the paragraph descriping shows that 16401-14-2 is playing an increasingly important role.

Reference£º
Patent; Hoffmann-La Roche Inc.; US6355653; (2002); B1;,
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354795-62-3, 3-Methylisoxazol-4-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 435-Chloro-4-[(3,3-difluoro-1-pyrrolidinyl)carbonyl]- V-(3-methyl-4-isoxazolyl)-2- [(phenylmethyl)oxy]benzamide (E43)To a solution of 5-chloro-4-[(3,3-difluoro-1-pyrrolidinyl)carbonyl]-2- [(phenylmethyl)oxy]benzoic acid (may be prepared as described in Description 65; 90 mg, 0.23 mmol) in N,N-dimethylformamide (3 ml) was added diisopropylethylamine (0.08 ml, 0.46 mmol), HATU (156 mg, 0.41 mmol) and 3-methyl-4-isoxazolamine (26.8 mg, 0.27 mmol). The solution was stirred for 18 hours. The solvent removed in vacuo and purified by MDAP to give the title compound as a white solid. 65 mg.MS (electrospray): m/z [M+H]+ 4761 H NMR (DMSO-d6): 1.94 (3 H, d, J=3.26 Hz), 2.40 – 2.60 (2 H, m), 3.40 (1 H, t, J=7.28 Hz), 3.54 – 3.68 (1 H, m), 3.75 (1 H, t, J=7.53 Hz), 3.93 (1 H, t, J=13.18 Hz), 5.28 (2 H, s), 7.32 – 7.45 (4 H, m), 7.51 (2 H, d, J=6.78 Hz), 7.81 (1 H, s), 9.16 (1 H, s), 9.97 (1 H, br. s.).

354795-62-3, The synthetic route of 354795-62-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James; WO2012/28629; (2012); A1;,
Isoxazole – Wikipedia
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