Category: Isoxazoles

62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62348-13-4, Preparation of N-[4-(1-Hydroxy-1-methyl-2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl]isoxazol-5-ylcarboxamide Scheme XII, Step A: Into a 100 mL single-neck flask, 159 mg of isoxazole-5-carbonyl chloride was added dropwise to 300 mg of [2-(4-aminophenyl)-2-hydroxypropyl][(methylethyl)sulfonyl]amine (prepared in example 19) and 122 mg of triethylamine in THF (35 mL) while stirring under a nitrogen atmosphere at room temperature. The reaction was allowed to stir at this temperature for 2 h. The mixture was then poured into H2O and the desired product was extracted into ethyl acetate. The organic layer was backwashed once with H2O, dried over K2CO3, and concentrated under reduced vacuum to yield 416 mg as a solid. This material was purified via recrystallization from ethyl acetate/hexane 1:1 to yield intermediate title compound (207 mg, 51%) as a white solid. Ion spray M.S. 366.1 (M*-1). Calculated for C16 H21 N3 O5 S

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; Eli Lilly and Company; US7034045; (2006); B1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

4369-55-5, 5-Amino-3-phenylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4369-55-5

A mixture of (R)-2-(5-bromo-6-cyanopyridin-3-ylamino)-4-methylpentanamide (80mg, 0.257 mmol), 5-amino-3-phenylisoxazole (44 mg, 0.275 mmol), NaOPh trihydrate (55 mg,0.323 mmol), xantphos (30 mg, 0.051 mmol) and Pd2dba3 (18 mg, 0.019 mmol) in dioxane (2mL) was degassed with Ar, then was stirred at 110 ¡ãC for 20 h. HOAc (0.1 mL) was added. The mixture was concentrated in vacuo. The residue was purified by HPLC to give (R)-2-(6-cyano-5-(3-phenylisoxazol-5-ylamino)pyridin-3-ylamino)-4-methylpentanamide (15 mg).

As the paragraph descriping shows that 4369-55-5 is playing an increasingly important role.

Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; SONG, Yonghong; XU, Qing; SRAN, Arvinder; BAUER, Shawn M.; JIA, Zhaozhong J.; KANE, Brian; PANDEY, Anjali; WO2013/192046; (2013); A2;,
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3356-89-6, 5-Chloro-3-phenylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred suspension of NaH (60% in mineral oil, 440 mg, 11 mmol, prewashed with hexane) in anhydrous THF (20 mL) was added the appropriate alcohol (15 mmol) at r.t. and the reaction mixture was stirred for 0.5 h. Next, 5-chloro-3-phenylisoxazole (2) (1.0 g, 5.6mmol) was introduced as a solid and the mixture was refluxed for 1 h. After cooling to r.t., the mixture was quenched with H2O (20 mL). For 4a and 4b, the resulting precipitate was collected, washed with H2O and recrystallized from hexane-Et2O mixture. For 3a, the reaction mixture was extracted with CH2Cl2 (3 ¡Á 20 mL). The combined organic layers were dried (Na2SO4) and concentrated in vacuo to give isoxazole 3a. 5-tert-Butoxy-3-phenylisoxazole (4c) was synthesized analogously using commercially available potassium tert-butoxide., 3356-89-6

3356-89-6 5-Chloro-3-phenylisoxazole 326080, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Article; Rostovskii, Nikolai V.; Agafonova, Anastasiya V.; Smetanin, Ilia A.; Novikov, Mikhail S.; Khlebnikov, Alexander F.; Ruvinskaya, Julia O.; Starova, Galina L.; Synthesis; vol. 49; 19; (2017); p. 4478 – 4488;,
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Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36958-61-9,5-(Bromomethyl)-3-methylisoxazole,as a common compound, the synthetic route is as follows.

tert-Butyl 2-[4-(5-chloro-2-fluorophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-(3-methyl-1,2-oxazol-5-yl)propanoate (Racemate) To a solution of 900 mg (2.45 mmol) of tert-butyl [4-(5-chloro-2-fluorophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]acetate in 18 ml of tetrahydrofuran under argon at -78 C. were added dropwise 3.06 ml (1.0 M in THF, 1.25 eq.) of lithium bis(trimethylsilyl)amide, and the mixture was stirred for 30 min. Subsequently, 635 mg (3.43 mmol, 1.4 eq.) of 5-(bromomethyl)-3-methyl-1,2-oxazole were added. The resulting reaction mixture was stirred at -78 C. for another 30 min and at RT for another 90 min. Saturated aqueous ammonium chloride solution was added to the reaction mixture. After phase separation, the aqueous phase was extracted with ethyl acetate. The combined organic phases were washed with saturated aqueous sodium chloride solution. The organic phase was dried (sodium sulphate), filtered and concentrated under reduced pressure. The crude product was then purified by means of normal phase chromatography (eluent: cyclohexane/ethyl acetate (0-38%) mixtures). Yield: 1.00 g (88% of theory) LC/MS [Method 1]: Rt=1.10 min; MS (ESIpos): m/z=463 (M+H)+, 1H-NMR (400 MHz, DMSO-d6): delta [ppm]=7.54 (ddd, 1H), 7.48 (dd, 1H), 7.35 (t, 1H), 7.31 (s, 1H), 6.43 (s, 1H), 6.13 (s, 1H), 5.35 (dd, 1H), 3.68-3.56 (m, 2H), 3.55 (s, 3H), 2.16 (s, 3H), 1.40 (m, 9H).

36958-61-9, As the paragraph descriping shows that 36958-61-9 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROeHRIG, Susanne; JIMENEZ NUNEZ, Eloisa; SCHLEMMER, Karl-Heinz; TERSTEEGEN, Adrian; TELLER, Henrik; HILLISCH, Alexander; HEITMEIER, Stefan; SCHMIDT, Martina Victoria; STAMPFUss, Jan; (82 pag.)US2017/298052; (2017); A1;,
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1202769-66-1, 2-(5-Methylisoxazol-3-yl)but-3-yn-2-ol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2-Synthesis of 4-[1-(2-aminopyrimidin-4-yl)-2-(oxan-4-yloxy)-1H-1,3-benzodiazol-6-yl]-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol A mixture of 4-[6-bromo-2-(oxan-4-yloxy)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine (150 mg, 0.27 mmol, 70%), 2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol (200 mg, 1.32 mmol), bis(triphenylphosphine)palladium(II) dichloride (220 mg, 0.31 mmol) and triethylamine (1 mL) in dimethylsulfoxide (2 mL) was stirred under nitrogen atmosphere for 5 hr at 70 C. The reaction mixture was cooled to room temperature then filtered through a frit filter to remove the catalyst. The filtrate was purified by preparative HPLC to give 30 mg (24%) of 4-[1-(2-aminopyrimidin-4-yl)-2-(oxan-4-yloxy)-1H-1,3-benzodiazol-6-yl]-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol as a white solid. 1H NMR (400 MHz, DMSO) delta 8.41 (d, J=5.6 Hz, 1H), 8.15 (s, 1H), 7.46 (d, J=8.0 Hz, 1H), 7.28-7.07 (m, 1H), 7.08 (s, 2H), 6.99 (d, J=5.6 Hz, 1H), 6.46 (s, 1H), 6.37 (s, 1H), 5.39-5.35 (m, 1H), 3.88-3.82 (m, 2H), 3.06-3.55 (m, 2H), 2.51 (s, 3H), 2.24-2.16 (m, 2H), 1.88-1.82 (m, 5H); LC-MS: m/z=+461 (M+H)+., 1202769-66-1

1202769-66-1 2-(5-Methylisoxazol-3-yl)but-3-yn-2-ol 58221759, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; Genentech, Inc.; US2012/214762; (2012); A1;,
Isoxazole – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108655-63-6,3-(Trifluoromethyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.

To a solution of 3-(trifluoromethyl)isoxazol-5-amine (0.77 g) in DMF (10 mL) is added NaH (60% oil disp.). The resulting mixture is stirred for 20 min and then 4-ethoxy-1-isothiocyanato-2-nitrobenzene (see Dyson, G. M.; George, H. J.; Hunter, R. F. J. Chem. Soc. 1927, 436-445) (0.22 g) is added. The resulting mixture is stirred for 30 min, concentrated to dryness, taken-up in EtOAc, washed with brine, and purified utilizing preparatory HPLC. Yield 9%. HRMS (EI) calcd for C13H11F3N4O4S 376.0453, found 376.0450., 108655-63-6

The synthetic route of 108655-63-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Piotrowski, David W.; Rogers, Bruce N.; McWhorter JR., William W.; Walker, Daniel Patrick; Corbett, Jeffrey W.; Groppi JR., Vincent E.; Rudmann, Daniel G.; US2003/236287; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem

62348-13-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 33 Isoxazole-5-carboxylic acid [6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-yl]-amide As described for example 18, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine (280 mg, 1 mmol) was converted, using isoxazole-5-carbonyl chloride instead of methoxyacetyl chloride, to the title compound (290 mg, 77%) which was obtained as a white solid. MS: m/e=378.2 [M+H]+.

62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; Buettelmann, Bernd; Jakob-Roetne, Roland; Knust, Henner; Thomas, Andrew; US2009/143385; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1136-45-4,5-Methyl-3-phenylisoxazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

A solution of 5-methyl-3-phenylisoxazole-4-carboxylic acid (60 mg, 0.3 mmol), DIEA (46 mg, 0.36 mmol), and DPPA (100 mg, 0.38 mmol) in toluene (1 mL) was shaken for 30 minutes at room temperature and then heated and shaken at 90 C for 16 h. The reaction mixture was then added to the resin from step A and mixture shaken for 5 h at 90 C. The reaction mixture was filtered and the resin was washed with 3 times each with DMF, 1 : 1 acetic acid/DCM, water, isopropanol and finally with DCM. The resin was then dried in a vacuum oven for 2 h., 1136-45-4

1136-45-4 5-Methyl-3-phenylisoxazole-4-carboxylic acid 14343, aIsoxazoles compound, is more and more widely used in various.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; COOKE, Andrew, J.; STUMP, Craig, A.; ZHANG, Xu-Fang; LI, Chun Sing; MAO, Qinghua; WO2015/42085; (2015); A2;,
Isoxazole – Wikipedia
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1006-67-3, 5-Phenylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Triarylpyridylidene-gold complex AuCl(PyC) (6.4 mg, 10 mumol, 5 mol %), heteroarene (0.20 mmol), and aryl(trimethyl)silane (0.20 mmol), 2-iodosobenzoic acids (IBA) (53 mg, 0.20 mmol), (+)-10-camphorsulfonic acid (CSA) (47 mg, 0.20 mmol) and a stirring bar were placed in a screw test tube, and dry chloroform/methanol (1.0 mL/0.10 mL) was added under N2 atmosphere. The tube was sealed with a cap equipped with a Teflon-coated silicon rubber septum, and the mixture was stirred at 65 C for 18-48 h. The reaction was quenched by addition of excess saturated NaHCO3 aq, the aqueous layer was extracted with dichloromethane and the combined organic layers were dried over Na2SO4, filtrated, and concentrated under reduced pressure. The residue was purified by flash chromatography (FC) to afford the coupling product.

1006-67-3, As the paragraph descriping shows that 1006-67-3 is playing an increasingly important role.

Reference£º
Article; Hata, Kazuhiro; Ito, Hideto; Segawa, Yasutomo; Itami, Kenichiro; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 2737 – 2746;,
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Isoxazole | C3H3NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51677-09-9,Methyl 5-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.

51677-09-9, EXAMPLES 32 TO 34General Reaction Sequence[00350] To diisopropylamine (0.04 mL, 0.314 mmol) in THF was added a solution of butyllithium (2.6 M in hexanes, 0.12 mL, 0.314 mmol) at 0 C and stirred for 30 mins. at 0 C. To the reaction mixture was added 6-methoxy-3,4-dihydronaphthalen-l(2H)-one oxime (Intermediate 2) (30 mg, 0.157 mmol) dissolved in 0.5 mL of THF at 0 C and stirred for 30 mins. The corresponding ester (0.102 mmol, 0.65 eqv.) in 0.5 mL of THF was added at 0 C and stirred at room temperature for 40 mins. To the reaction mixture was then added 0.1 mL of concentrated sulfuric acid at 0 C and stirred for 1 h at room temperature. The reaction was monitored by LCMS and when complete conversion to the product was observed, the reaction mixture was concentrated, water added (2 mL) and extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulphate and concentrated to give the crude isoxazole derivative.[00351] To the crude isoxazole derivative was added 0.5 mL of dichloromethane followed by 3 mL of boron tribromide in dichloromethane at 0 C and stirred for 5 h at room temperature. The reaction mixture was quenched with methanol (2 mL) and concentrated. The residue was purified by Prep HPLC (XBridge, 19 x 100, 5u, 20 min. gradient; Solvent A: 10 mM NH4OAc, Solvent B: MeOH) to afford products shown in Table 1. The following esters were employed in the synthesis of final products employing this protocol.

As the paragraph descriping shows that 51677-09-9 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; DHAR, T.G. Murali; XIAO, Hai-Yun; WATTERSON, Scott Hunter; KO, Soo S.; DYCKMAN, Alaric J.; LANGEVINE, Charles M.; DAS, Jagabandhu; CHERNEY, Robert J.; WO2011/59784; (2011); A1;,
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