Category: isoxazole

Li, Long published the artcileRegioselectivity Switch in Palladium-Catalyzed Allenylic Cycloadditions of Allenic Esters: [4+1] or [4+3] Cycloaddition/Cross-Coupling, Category: isoxazole, the publication is Angewandte Chemie, International Edition (2019), 58(14), 4710-4713, database is CAplus and MEDLINE.

The first Pd-catalyzed asym. allenylic [4+1] cycloaddition was successfully developed. Alternatively, tuning the Pd catalyst switched the reactivity toward an unprecedented [4+3] cycloaddition/cross-coupling. Ligands play a vital role in controlling the reaction pathway, allowing highly selective access to different products from identical substrates. Biol. evaluation of the obtained compounds led to the discovery of new antitumor targets. A possible mechanism is proposed, suggesting two interesting catalytic cycles for the cycloaddition with palladium-butadienyls. This study also demonstrated the potential and utility of allenic esters as 1,4-biselectrophiles and C₄ synthons for participating in cycloaddition reactions.

Angewandte Chemie, International Edition published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Category: isoxazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Luo, Xi published the artcileAnalgesic effect of different dosage of Flurbiprofen axetil in laparoseopic cholecystectomy in comparison with other analgesic drugs, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Pakistan Journal of Pharmaceutical Sciences (2017), 30(5), 1895-1898, database is CAplus.

Flurbiprofen axetil is a non-selective cyclooxygenase inhibitor. It can target the aggregation with lipid micro sphere as drug carrier. and exert analgesic effect in surgical incision and inflammatory site. In laparoscopic cholecystectomy comparative study on analgesic effect of parecoxib and flurbiprofen axetil is relatively less. Therefore. this paper is mainly based on the observation of patients after resting VAS score. adverse reaction time and movement. to evaluate the analgesic effect of different drug dose of flurbiprofen and parecoxib sodium. which provides reference for clin. medication. The results show that the i.v. injection of parecoxib could provide effective analgesic effect in laparoscopic cholecystectomy. Also. compared with flurbiprofen. parccoxib shows a more significant analgesic effect.

Pakistan Journal of Pharmaceutical Sciences published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Li, Chang-liang published the artcileGradient elution HPLC for related substances in parecoxib sodium for injection, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Zhongnan Yaoxue (2014), 12(3), 268-270, database is CAplus.

An HPLC method was developed to determine the relevant substances in parecoxib sodium for injection. An Agilent C₁₈ column (150 mm 脳 4.6 mm, 5 渭m) was used with gradient elution. The flow-rate was 1 mL 路 min^-1. The detection wavelength was 214 nm. Parecoxib and the adjacent impurities were effectively separated The sample solution was stable in 12 h at the room temperature The average recoveries low, middle and high concentration of valdecoxib was 100.2%, 100.3% and 99.4%. The method is accurate, reliable and reproducible, and can be used for the quality control of the preparation

Zhongnan Yaoxue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Mallick, Sudesh published the artcileOxidative Coupling of Carbazoles: A Substituent-Governed Regioselectivity Profile, Synthetic Route of 57103-14-7, the publication is Journal of Organic Chemistry (2019), 84(1), 73-93, database is CAplus and MEDLINE.

Oxidative C-C coupling of carbazoles possessing various substituents is demonstrated in the presence of organic (metal-free) recyclable oxidants, such as DDQ or CA/H⁺, for accessing bicarbazole regioisomers. Differently substituted carbazoles are examined to showcase regioselective discrimination (3,3′- vs. 1,3′-bicarbazoles) and preferences based on sterics and electronics in oxidative coupling. Finally, a mechanism that involves the carbazole radical cation has been traced (evidenced) and proposed on the basis of the UV-vis-NIR absorption and EPR spectroscopy results. This study underlines the strategic chem. preparation of a series of bicarbazoles in an efficient manner.

Journal of Organic Chemistry published new progress about 57103-14-7. 57103-14-7 belongs to isoxazole, auxiliary class Fused Tricycles,Carbazoles, name is 9-(4-Fluorophenyl)-9H-carbazole, and the molecular formula is C18H12FN, Synthetic Route of 57103-14-7.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Lin, Jin-bing published the artcileEffect of parecoxib sodium on intravenous analgesic effect of dezocine after cesarean section, Computed Properties of 198470-85-8, the publication is Guangdong Yixue (2017), 38(7), 1098-1100, database is CAplus.

Objective: To observe the effect of parecoxib sodium on the analgesic effect of dezocine after cesarean section and its adverse reactions. Methods: 80 patients with ASA I-II grades combined spinal-epidural anesthesia who underwent voluntary postoperative analgesia after cesarean section were divided into parecoxib sodium group (P group) and control group (C group) according to the random number table, 40 cases in each. After the fetus was delivered, group P received i.v. injection of parecoxib sodium 40 mg, and group C received i.v. injection of the same amount of normal saline. After the operation, self-controlled i.v. analgesia with dezocine was used, and the analgesic solution was dezocine 0.5 mg /kg + normal saline to 100 mL. Adopt LCP mode of administration was used: loading dose (dezocine 5 mg) + maintenance dose 2.0 mL/h + single PCA dose 1 mL, lock-in time 15 min. The visual analog (VAS) pain scores at 2, 4, 8, 12, and 24 h after the operation of the parturient were recorded. The degree of uterine contraction pain within 24 h after the operation was recorded, and the satisfaction of the parturient鈥瞫 analgesia and overall adverse reaction rate were compared. Results: The VAS scores of the incision at 8 and 12 h in the P group were significantly lower than those in the C group (P < 0.05). The degree of postoperative uterine contraction pain in group P was significantly lower than that in group C (P < 0.05). The overall satisfaction of analgesia in group P was significantly higher than that in group C (P < 0.05). There was no significant difference in the incidence of overall adverse reactions between the two groups (P > 0.05). Conclusion: Parecoxib sodium can enhance the effect of dezocine for i.v. patient-controlled analgesia after cesarean section, reduce the degree of uterine contraction pain, and improve women鈥瞫 satisfaction without increasing adverse reactions.

Guangdong Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Computed Properties of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Sridhar, Madabhushi published the artcileOne-step synthesis of 5-substituted 1H-tetrazoles from an aldehyde by reaction with acetohydroxamic acid and sodium azide under Bi(OTf)₃ catalysis, COA of Formula: C8H5F3N4, the publication is Synthesis (2013), 45(4), 507-510, database is CAplus.

An efficient one-step method for the synthesis of 5-substituted 1H-tetrazoles from aldehydes by reaction with acetohydroxamic acid and sodium azide using bismuth(III) triflate as the catalyst is described.

Synthesis published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C10H7NO3, COA of Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Joshi, Sameer M. published the artcileThe microwave-assisted synthesis of 5-substituted 1H-tetrazoles via [3+2] cycloaddition over a heterogeneous Cu-based catalyst: application to the preparation of ¹³N-labelled tetrazoles, Safety of 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, the publication is New Journal of Chemistry (2017), 41(16), 8084-8091, database is CAplus.

The [3+2] cycloaddition between various nitriles and sodium azide proceeded smoothly in the presence of a new Cu^II catalyst in N-methyl-2-pyrrolidone (NMP) to give the corresponding 5-substituted 1H-tetrazoles. The desired tetrazoles were obtained in high yields within 3-30 min by employing controlled microwave heating. The reaction most probably proceeded through the activation of the nitrile groups by the Cu^II species, followed by a successive [3+2] cycloaddition with the sodium azide. The good performance of the catalyst enabled the preparation of selected tetrazoles labeled with the positron emitter nitrogen-13 even under conventional heating. The short reaction time, simple work-up procedure, and recyclability of the catalyst were advantages of the method reported here.

New Journal of Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Safety of 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Moshkin, Vladimir S. published the artcileReinvestigation of the reaction between aromatic aldehydes, 3-phenyl-5-isoxazolone and sarcosine: Stabilized azomethine ylides as a synthetic equivalent of the methylaminomethyl anion, Synthetic Route of 1076-59-1, the publication is Tetrahedron Letters (2020), 61(16), 151770, database is CAplus.

The reaction of aromatic aldehydes, 3-phenyl-5-isoxazolone and sarcosine proceeded smoothly at reflux in methanol to give (Z)-4-arylidene-3-phenylisoxazol-5(4H)-ones, whereas addition of isatin to reaction mixture changes the result, providing oximes of 4-aryl-3-benzoyl-1-methylpyrrolidin-2-ones I [Ar = Ph, 4-O₂NC₆H₄, 2-naphthyl, etc.] in 38-72% yield.

Tetrahedron Letters published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Synthetic Route of 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Kausar, Nazia published the artcileA green synthetic approach toward the synthesis of structurally diverse spirooxindole derivative libraries under catalyst-free conditions, Quality Control of 1076-59-1, the publication is Molecular Diversity (2017), 21(2), 325-337, database is CAplus and MEDLINE.

A catalyst-free green methodol. for the synthesis of pharmacol. important spirooxindole derivatives has been developed by a three-component domino reaction between isatin, various amino compounds, and 1,3-dicarbonyl or 3-phenylisoxazolone compounds in Et L-lactate medium at room temperature This new efficient synthetic method facilitated the formation of a wide range of biol. significant spirooxindole derivatives (including 17 new spirooxindoles) under very mild conditions. The cytotoxic activity of one of the isoxazole-fused spirooxindoles was evaluated in MDA-MB 468 breast cancer cell line. It was found that cell survivability decreases with increasing concentration of the selected compound in MDA-MB 468 breast cancer cells.

Molecular Diversity published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Quality Control of 1076-59-1.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem

Elumalai, K. published the artcileCrystal structure analysis of 6-amino-5-(6-fluoro-3-phenylisoxazolo[5,4-b]quinolin-4-yl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, Application of 3-Phenylisoxazol-5(2H)-one, the publication is International Journal of ChemTech Research (2017), 10(4), 190-194, database is CAplus.

The crystal structure anal. of 6-amino-5-(6-fluoro-3-phenylisoxazolo[5,4-b]quinolin-4-yl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione was studied using x-ray diffraction method. The compound crystallizes in Monoclinic P21/c space group with unit cell parameters at 296(2) K as follows: a = 13.3119(5) 脜 , b = 10.7033(4) 脜 , c = 13.8141(4) 脜 , 伪 = 90掳, 尾 = 91.8261(12)掳, 纬 = 90掳. Crystal data was collected using BRUKER SMART APEX II CCD X-ray diffractometer. The structure was solved by direct methods and refined on F² by full-matrix least-squares procedures to the final R₁ of 0.0384 using SHELXL programs.

International Journal of ChemTech Research published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Application of 3-Phenylisoxazol-5(2H)-one.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem